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Tnfrsf8
Gene Detail
Symbol

Name
ID
Tnfrsf8
tumor necrosis factor receptor superfamily, member 8
MGI:99908
STS
Synonyms
CD30
Feature Type
protein coding gene
Genetic Map
Chromosome 4
78.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:145267137-145315164 bp, - strand
From VEGA annotation of GRCm38

  48028 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:949  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: TNFRSF8
Protein SuperFamily: tumor necrosis factor receptor superfamily member 8
Gene Tree: Tnfrsf8

Human
homologs
TNFRSF8, tumor necrosis factor receptor superfamily, member 8
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 943
neXtProt AC: NX_P28908

Human Synonyms: CD30, D1S166E, Ki-1

Human Chr (Location): 1p36; chr1:12063330-12144207 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(10) Targeted(4)
Genomic Mutations involving Tnfrsf8 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele display an enlarged thymus, impaired activation-induced death of double-positive thymocytes after CD3 cross-linking, and decreased susceptibility to graft versus host disease.
 
Interactions
Tnfrsf8 interacts with 280 markers (Mir1b, Mir15a, Mir18, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (46)    Tissues (45)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 46
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000010015 (Evidence)
Ensembl Gene Model ENSMUSG00000028602 (Evidence)
Entrez Gene 21941 (Evidence)
UniGene 12810
DFCI TC1591727
DoTS DT.91332424
NIA Mouse Gene Index U025770
Consensus CDS Project CCDS18915.1
International Mouse Phenotyping Consortium Status Tnfrsf8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010015 VEGA Gene Model | MGI Sequence Detail 48028 C57BL/6J ±  kb
transcript OTTMUST00000023287 VEGA | MGI Sequence Detail 3414 Not Applicable 
polypeptide OTTMUSP00000010648 VEGA | MGI Sequence Detail 498 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(437 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR020416 Tumour necrosis factor receptor 8
Protein Ontology PR:000001964 tumor necrosis factor receptor superfamily member 8
References
(Earliest) J:3463 Clayton LK, et al., Differential regulation of T-cell receptor processing and surface expression affected by CD3 theta, an alternatively spliced product of the CD3 zeta/eta gene locus. J Biol Chem. 1992 Dec 25;267(36):26023-30
(Latest) J:200593 Guo Y, et al., CD30 Is Required for Activation of a Unique Subset of Interleukin-17A-Producing gammadelta T Cells in Innate Immunity against Mycobacterium bovis Bacillus Calmette-Guerin Infection. Infect Immun. 2013 Oct;81(10):3923-34
All references(61)
Other
accession IDs
MGD-MRK-16705

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory