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Tnfrsf8
Gene Detail
 Symbol
Name
ID
Tnfrsf8
tumor necrosis factor receptor superfamily, member 8
MGI:99908
STS D4Nds23
Synonyms CD30
Feature Type protein coding gene
Genetic Map
Chromosome 4
78.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:145267137-145315164 bp, - strand
From VEGA annotation of GRCm38

  48028 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:949  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: tumor necrosis factor receptor superfamily member 8
Gene Tree: Tnfrsf8

Human
homologs
Human Homolog TNFRSF8, tumor necrosis factor receptor superfamily, member 8
NCBI Gene ID 943
neXtProt AC  NX_P28908
Human Synonyms  CD30, D1S166E, Ki-1
Human Chr (Location)  1p36; chr1:12063377-12144207 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(10) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display an enlarged thymus, impaired activation-induced death of double-positive thymocytes after CD3 cross-linking, and decreased susceptibility to graft versus host disease.
 
Interactions
Tnfrsf8 interacts with 280 markers (Mir1b, Mir15a, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process positive regulation of apoptotic process, positive regulation of NF-kappaB transcription factor activity, ...
Component extracellular vesicular exosome, integral component of membrane, ...
Function transmembrane signaling receptor activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28
Assay TypeResults
RT-PCR 46
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000010015 (Evidence)
Ensembl Gene ModelENSMUSG00000028602 (Evidence)
Entrez Gene21941 (Evidence)
UniGene12810
DFCITC1591727
DoTSDT.91332424
NIA Mouse Gene IndexU025770
Consensus CDS ProjectCCDS18915.1
International Mouse Knockout Project StatusTnfrsf8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010015 VEGA Gene Model | MGI Sequence Detail 48028 C57BL/6J ±  kb
transcript OTTMUST00000023287 VEGA | MGI Sequence Detail 3414 Not Applicable 
polypeptide OTTMUSP00000010648 VEGA | MGI Sequence Detail 498 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(437 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR020416 Tumour necrosis factor receptor 8
Protein Ontology PR:000001964 tumor necrosis factor receptor superfamily member 8
References (Earliest) J:3463 Clayton LK, et al., Differential regulation of T-cell receptor processing and surface expression affected by CD3 theta, an alternatively spliced product of the CD3 zeta/eta gene locus. J Biol Chem. 1992 Dec 25;267(36):26023-30
(Latest) J:200593 Guo Y, et al., CD30 Is Required for Activation of a Unique Subset of Interleukin-17A-Producing gammadelta T Cells in Innate Immunity against Mycobacterium bovis Bacillus Calmette-Guerin Infection. Infect Immun. 2013 Oct;81(10):3923-34
All references(64)
Other
accession IDs
MGD-MRK-16705

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory