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Plod1
Gene Detail
Symbol

Name
ID
Plod1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
MGI:99907
Synonyms
2410042F05Rik, LH1, lysyl hydroxylase 1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
78.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:147909753-147936767 bp, - strand
From VEGA annotation of GRCm38

  27015 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLOD1
Protein SuperFamily: procollagen-lysine 5-dioxygenase
Gene Tree: Plod1

Human
homologs
PLOD1, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5351
neXtProt AC: NX_Q02809

Human Synonyms: EDS6, LH, LH1, LLH, PLOD

Human Chr (Location): 1p36.22; chr1:11934667-11975542 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PLOD1

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(5) Targeted(4)
Genomic Mutations involving Plod1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit hypotonia, reduced voluntary movement, abnormal aorta and skin collagen fibers, irregular vascular smooth muscle and premature death associated with thoracic cavity hemorrhage and aortic dissection.
 
Human Diseases Modeled in Mice Using Plod1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Plod1 interacts with 112 markers (Mir1a-1, Mir1a-2, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process epidermis development, oxidation-reduction process, ...
Component endoplasmic reticulum, extracellular exosome, ...
Function dioxygenase activity, ferrous iron binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (267)    Tissues (133)    Images (58)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 253
RT-PCR 14
cDNA source data(135)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase plod1 ; ZFIN plod1a    NEW 
Molecular
reagents
All nucleic(137) cDNA(135) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000010675 (Evidence)
Ensembl Gene Model ENSMUSG00000019055 (Evidence)
Entrez Gene 18822 (Evidence)
UniGene 37371
DFCI TC1572521, TC1609009, TC1763931
DoTS DT.101404040, DT.101408342, DT.110817129, DT.492717, DT.94367259, DT.97398657
NIA Mouse Gene Index U025778
EC 1.14.11.4
Consensus CDS Project CCDS18924.1
International Mouse Phenotyping Consortium Status Plod1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010675 VEGA Gene Model | MGI Sequence Detail 27015 C57BL/6J ±  kb
transcript OTTMUST00000024908 VEGA | MGI Sequence Detail 3243 Not Applicable 
polypeptide OTTMUSP00000011428 VEGA | MGI Sequence Detail 728 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(2) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(355 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005123 Oxoglutarate/iron-dependent dioxygenase
InterPro IPR001006 Procollagen-lysine 5-dioxygenase
InterPro IPR006620 Prolyl 4-hydroxylase, alpha subunit
Protein Ontology PR:000012876 procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
References
(Earliest) J:488 Hautala T, et al., Cloning of human lysyl hydroxylase: complete cDNA-derived amino acid sequence and assignment of the gene (PLOD) to chromosome 1p36.3----p36.2. Genomics. 1992 May;13(1):62-9
(Latest) J:214961 Milgrom-Hoffman M, et al., Endothelial cells regulate neural crest and second heart field morphogenesis. Biol Open. 2014;3(8):679-88
All references(48)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16704, MGI:1913722, MGI:2140400, MGI:2140511

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory