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Plod1
Gene Detail
Symbol

Name
ID
Plod1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
MGI:99907
Synonyms
2410042F05Rik, LH1, lysyl hydroxylase 1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
78.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:147909753-147936767 bp, - strand
From VEGA annotation of GRCm38

  27015 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: procollagen-lysine 5-dioxygenase
Gene Tree: Plod1

Human
homologs
Human Homolog PLOD1, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
NCBI Gene ID 5351
neXtProt AC  NX_Q02809
Human Synonyms  EDS6, LH, LH1, LLH, PLOD
Human Chr (Location)  1p36.22; chr1:11934667-11975542 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PLOD1
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(5) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit hypotonia, reduced voluntary movement, abnormal aorta and skin collagen fibers, irregular vascular smooth muscle and premature death associated with thoracic cavity hemorrhage and aortic dissection.
 
Human Diseases Modeled Using Mouse Plod1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Plod1 interacts with 112 markers (Mir1a-1, Mir1a-2, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process epidermis development, oxidation-reduction process, ...
Component endoplasmic reticulum, extracellular vesicular exosome, ...
Function dioxygenase activity, ferrous iron binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (267)    Tissues (133)    Images (58)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 253
RT-PCR 14
cDNA source data(135)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(137) cDNA(135) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000010675 (Evidence)
Ensembl Gene ModelENSMUSG00000019055 (Evidence)
Entrez Gene18822 (Evidence)
UniGene37371
DFCITC1572521, TC1609009, TC1763931
DoTSDT.101404040, DT.101408342, DT.110817129, DT.492717, DT.94367259, DT.97398657
NIA Mouse Gene IndexU025778
EC1.14.11.4
Consensus CDS ProjectCCDS18924.1
International Mouse Knockout Project StatusPlod1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010675 VEGA Gene Model | MGI Sequence Detail 27015 C57BL/6J ±  kb
transcript OTTMUST00000024908 VEGA | MGI Sequence Detail 3243 Not Applicable 
polypeptide OTTMUSP00000011428 VEGA | MGI Sequence Detail 728 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(2) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(355 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005123 Oxoglutarate/iron-dependent dioxygenase
InterPro IPR001006 Procollagen-lysine 5-dioxygenase
InterPro IPR006620 Prolyl 4-hydroxylase, alpha subunit
Protein Ontology PR:000012876 procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
References
(Earliest) J:488 Hautala T, et al., Cloning of human lysyl hydroxylase: complete cDNA-derived amino acid sequence and assignment of the gene (PLOD) to chromosome 1p36.3----p36.2. Genomics. 1992 May;13(1):62-9
(Latest) J:189252 Tao G, et al., Collagen XIV is important for growth and structural integrity of the myocardium. J Mol Cell Cardiol. 2012 Nov;53(5):626-38
All references(47)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16704, MGI:1913722, MGI:2140400, MGI:2140511

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory