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Hnrnpk Gene Detail
Summary
  • Symbol
    Hnrnpk
  • Name
    heterogeneous nuclear ribonucleoprotein K
  • Synonyms
    hnRNPK, Hnrpk, KBBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:99894
    NCBI Gene: 15387
  • Gene Overview
    MyGene.info: HNRNPK
Location & Maps
more
  • Sequence Map
    Chr13:58391142-58403343 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      12202 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 31.04 cM, cytoband B2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HNRNPK, heterogeneous nuclear ribonucleoprotein K
  • Vertebrate Orthologs
    7
  • Human Ortholog
    HNRNPK, heterogeneous nuclear ribonucleoprotein K
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AUKS, CSBP, HNRPK, TUNP
  • Links
    NCBI Gene ID: 3190
    neXtProt AC: NX_P61978

  • Chr Location
    9q21.32-q21.33; chr9:83968083-83980654 (-)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with human HNRNPK associations

Human Disease Mouse Models
       Au-Kline Syndrome; AUKS   OMIM: 616580
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    37
  • Chemically induced (other)
    1
  • Gene trapped
    35
  • Targeted
    1
  • Genomic Mutations
    1 involving Hnrnpk
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    76
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    43
  • Tissues
    35
  • cDNA Data
    22
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035894 VEGA Gene Model | MGI Sequence Detail 12202 C57BL/6J ±  kb
transcript OTTMUST00000092042 VEGA | MGI Sequence Detail 2970 Not Applicable  
polypeptide OTTMUSP00000050778 VEGA | MGI Sequence Detail 464 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    22 from dbSNP Build 142
Protein
Information
less
  • UniProt
    17 Sequences
  • Protein Ontology
    PR:000008669 heterogeneous nuclear ribonucleoprotein K
  • InterPro Domains
    IPR033090 Heterogeneous nuclear ribonucleoprotein K
    IPR004087 K Homology domain
    IPR009019 K homology domain, prokaryotic type
    IPR004088 K Homology domain, type 1
    IPR012987 ROK, N-terminal
Molecular
Reagents
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  • All nucleic 25
    cDNA 23
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-16689
References
more
  • Summaries
    All 52
    Developmental Gene Expression 4
    Gene Ontology 11
    Phenotypes 11
  • Earliest
    J:18981 Ostrowski J, et al., Purification, cloning, and expression of a murine phosphoprotein that binds the kappa B motif in vitro identifies it as the homolog of the human heterogeneous nuclear ribonucleoprotein K protein. Description of a novel DNA-dependent phosphorylation pocess. J Biol Chem. 1994 Jul 1;269(26):17626-34
  • Latest
    J:225947 Gallardo M, et al., hnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies. Cancer Cell. 2015 Oct 12;28(4):486-99
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory