Pitpna
Gene Detail

Symbol Name ID

Pitpna phosphatidylinositol transfer protein, alpha MGI:99887

Synonyms

Pitp alpha, PITPalpha, Pitpn

Feature Type

protein coding gene

Genetic Map

Chromosome 11

45.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr11:75588097-75628804 bp, + strand From VEGA annotation of GRCm38   40708 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55958  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: phosphatidylinositol transfer protein
Gene Tree: Pitpna

Human homologs

Human Homolog		PITPNA, phosphatidylinositol transfer protein, alpha
NCBI Gene ID		5306
neXtProt AC		NX_Q00169
Human Synonyms		PI-TPalpha, PITPN, VIB1A
Human Chr (Location)		17p13.3; chr17:1421283-1466110 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(565) : Targeted(3) Gene trapped(561) Spontaneous(1)
 

Mutations of this gene result in motor coordination abnormalities and early death.

 
Human Diseases Modeled Using Mouse Pitpna (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	phospholipid transport, transport
Component	cytoplasm, integral to membrane, ...
Function	fatty-acyl-CoA binding, lipid binding, ...

External Resources: FuncBase

Expression

cDNA source data(202)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(207) Genomic(4) cDNA(203)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006217 (Evidence)
Ensembl Gene Model	ENSMUSG00000017781 (Evidence)
Entrez Gene	18738 (Evidence)
UniGene	3128
DFCI	TC1572541, TC1607335
DoTS	DT.534905, DT.97409924
NIA Mouse Gene Index	U012955, U172968, U273484
PDB	1KCM
Consensus CDS Project	CCDS25052.1
International Mouse Knockout Project Status	Pitpna

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006217	VEGA Gene Model | MGI Sequence Detail	40708	C57BL/6J
transcript	OTTMUST00000014037	VEGA | MGI Sequence Detail	3761	Not Applicable
polypeptide	OTTMUSP00000006520	VEGA | MGI Sequence Detail	271	Not Applicable

All sequences(72) RefSeq(2) UniProt(8)

Polymorphisms

RFLP(1) : SNPs(116 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001666	Phosphatidylinositol transfer protein
InterPro	IPR023393	START-like domain
Protein Ontology	PR:000012753	phosphatidylinositol transfer protein alpha isoform

References

(Earliest) J:24779 Lane PW, Vibrator (vb). Mouse News Lett. 1965;32:47
(Latest) J:170900 Concepcion D, et al., Modifier Genes for Mouse Phosphatidylinositol Transfer Protein {alpha} (vibrator) That Bypass Juvenile Lethality. Genetics. 2011 Apr;187(4):1185-91
All references(60)

Other accession IDs

MGD-MRK-15382, MGD-MRK-16680, MGI:98924