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Pitpna
Gene Detail
 Symbol
Name
ID
Pitpna
phosphatidylinositol transfer protein, alpha
MGI:99887
Synonyms Pitp alpha, PITPalpha, Pitpn
Feature Type protein coding gene
Genetic Map
Chromosome 11
45.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr11:75588097-75628804 bp, + strand
From VEGA annotation of GRCm38

  40708 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55958  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phosphatidylinositol transfer protein
Gene Tree: Pitpna

Human
homologs
Human Homolog PITPNA, phosphatidylinositol transfer protein, alpha
NCBI Gene ID 5306
neXtProt AC  NX_Q00169
Human Synonyms  HEL-S-36, PI-TPalpha, PITPN, VIB1A
Human Chr (Location)  17p13.3; chr17:1517989-1562816 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(565) : Gene trapped(561) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations of this gene result in motor coordination abnormalities and early death.
 
Human Diseases Modeled Using Mouse Pitpna (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Pitpna interacts with 367 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process phospholipid transport, transport
Component cytoplasm, extracellular vesicular exosome, ...
Function fatty-acyl-CoA binding, lipid binding, ...
External Resources: FuncBase
Expression
cDNA source data(198)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(203) Genomic(4) cDNA(199)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006217 (Evidence)
Ensembl Gene ModelENSMUSG00000017781 (Evidence)
Entrez Gene18738 (Evidence)
UniGene3128
DFCITC1572541, TC1607335
DoTSDT.534905, DT.97409924
NIA Mouse Gene IndexU012955, U172968, U273484
PDB1KCM
Consensus CDS ProjectCCDS25052.1
International Mouse Knockout Project StatusPitpna
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006217 VEGA Gene Model | MGI Sequence Detail 40708 C57BL/6J ±  kb
transcript OTTMUST00000014037 VEGA | MGI Sequence Detail 3761 Not Applicable 
polypeptide OTTMUSP00000006520 VEGA | MGI Sequence Detail 271 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(2) UniProt(8)
Polymorphisms RFLP(1) : SNPs within 2kb(137 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001666 Phosphatidylinositol transfer protein
InterPro IPR023393 START-like domain
Protein Ontology PR:000012753 phosphatidylinositol transfer protein alpha isoform
References (Earliest) J:24779 Lane PW, Vibrator (vb). Mouse News Lett. 1965;32:47
(Latest) J:170900 Concepcion D, et al., Modifier Genes for Mouse Phosphatidylinositol Transfer Protein {alpha} (vibrator) That Bypass Juvenile Lethality. Genetics. 2011 Apr;187(4):1185-91
All references(61)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15382, MGD-MRK-16680, MGI:98924

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory