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Ppm1a Gene Detail
Summary
  • Symbol
    Ppm1a
  • Name
    protein phosphatase 1A, magnesium dependent, alpha isoform
  • Synonyms
    2310003C21Rik, 2900017D14Rik, MMPa-2, MPPa-1, Mpp alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:99878
    NCBI Gene: 19042
  • Gene Overview
    MyGene.info: PPM1A
Location & Maps
more
  • Sequence Map
    Chr12:72761211-72794940 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33730 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 30.26 cM, cytoband C3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PPM1A, protein phosphatase, Mg2+/Mn2+ dependent 1A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPM1A, protein phosphatase, Mg2+/Mn2+ dependent 1A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PP2CA, PP2Calpha, PP2C-ALPHA
  • Links
    NCBI Gene ID: 5494
    neXtProt AC: NX_P35813

  • Chr Location
    14q23.1; chr14:60245752-60299087 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56428
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: PPM1A
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 4 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    3 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    45
  • Chemically induced (other)
    1
  • Gene trapped
    35
  • Targeted
    9
  • Genomic Mutations
    1 involving Ppm1a
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit delayed wound healing, delayed re-epithelialization, and decreased keratinocyte migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021096 Ensembl Gene Model | MGI Sequence Detail 33730 C57BL/6J ±  kb
transcript ENSMUST00000021514 Ensembl | MGI Sequence Detail 2789 Not Applicable  
polypeptide ENSMUSP00000021514 Ensembl | MGI Sequence Detail 382 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    172 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013090 protein phosphatase 1A
  • EC
  • InterPro Domains
    IPR000222 PPM-type phosphatase, divalent cation binding
    IPR001932 PPM-type phosphatase domain
    IPR015655 Protein phosphatase 2C family
    IPR012911 Protein serine/threonine phosphatase 2C, C-terminal
Molecular
Reagents
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  • All nucleic 20
    cDNA 20

    Microarray probesets 14
Other
Accession IDs
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MGD-MRK-16669, MGI:1916736, MGI:1920167, MGI:2144816, MGI:2144943
References
more
  • Summaries
    All 47
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 14
  • Earliest
    J:19652 Kato S, et al., The cDNA sequence encoding mouse Mg2+ -dependent protein phosphatase alpha. Gene. 1994 Aug 5;145(2):311-2
  • Latest
    J:217224 Zhao Y, et al., C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation. J Biol Chem. 2014 Sep 19;289(38):26441-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory