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Ppm1a
Gene Detail
Symbol

Name
ID
Ppm1a
protein phosphatase 1A, magnesium dependent, alpha isoform
MGI:99878
Synonyms
2310003C21Rik, 2900017D14Rik, MMPa-2, MPPa-1, Mpp alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 12
30.26 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:72761211-72794940 bp, + strand
From Ensembl annotation of GRCm38

  33730 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56428  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PPM1A
Gene Tree: Ppm1a

Human
homologs
PPM1A, protein phosphatase, Mg2+/Mn2+ dependent, 1A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5494
neXtProt AC: NX_P35813

Human Synonyms: PP2CA, PP2Calpha, PP2C-ALPHA

Human Chr (Location): 14q23.1; chr14:60245752-60299087 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Gene trapped(35) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit delayed wound healing, delayed re-epithelialization, and decreased keratinocyte migration.
 
Phenotype Images(3)
Interactions
Ppm1a interacts with 252 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (78)    Tissues (20)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 64
Northern blot 14
cDNA source data(19)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ppm1a ; ZFIN ppm1aa, ppm1ab    NEW 
Molecular
reagents
All nucleic(20) cDNA(20)
Microarray probesets(14)
Other database
links
Ensembl Gene Model ENSMUSG00000021096 (Evidence)
Entrez Gene 19042 (Evidence)
DFCI TC1574997, TC1579127, TC1624660, TC1658008, TC1662109, TC1667157, TC1731004, TC1735052
DoTS DT.101180715, DT.101344042, DT.101379561, DT.495292, DT.91328619, DT.97408867
NIA Mouse Gene Index U014068
EC 3.1.3.16
Consensus CDS Project CCDS25970.1
International Mouse Phenotyping Consortium Status Ppm1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021096 Ensembl Gene Model | MGI Sequence Detail 33730 C57BL/6J ±  kb
transcript ENSMUST00000021514 Ensembl | MGI Sequence Detail 2789 Not Applicable 
polypeptide ENSMUSP00000021514 Ensembl | MGI Sequence Detail 382 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015655 Protein phosphatase 2C
InterPro IPR000222 Protein phosphatase 2C, manganese/magnesium aspartate binding site
InterPro IPR001932 Protein phosphatase 2C (PP2C)-like
InterPro IPR012911 Protein serine/threonine phosphatase 2C, C-terminal
Protein Ontology PR:000013090 protein phosphatase 1A
References
(Earliest) J:19652 Kato S, et al., The cDNA sequence encoding mouse Mg2+ -dependent protein phosphatase alpha. Gene. 1994 Aug 5;145(2):311-2
(Latest) J:217224 Zhao Y, et al., C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation. J Biol Chem. 2014 Sep 19;289(38):26441-50
All references(48)
Other
accession IDs
MGD-MRK-16669, MGI:1916736, MGI:1920167, MGI:2144816, MGI:2144943

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory