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Ppm1a
Gene Detail
 Symbol
Name
ID
Ppm1a
protein phosphatase 1A, magnesium dependent, alpha isoform
MGI:99878
Synonyms 2310003C21Rik, 2900017D14Rik, MMPa-2, MPPa-1, Mpp alpha
Feature Type protein coding gene
Genetic Map
Chromosome 12
30.26 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:72761211-72794940 bp, + strand
From NCBI annotation of GRCm38

  33730 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56428  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ppm1a

Human
homologs
Human Homolog PPM1A, protein phosphatase, Mg2+/Mn2+ dependent, 1A
NCBI Gene ID 5494
neXtProt AC  NX_P35813
Human Synonyms  PP2CA, PP2Calpha, PP2C-ALPHA
Human Chr (Location)  14q23.1; chr14:60245752-60299087 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(35) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit delayed wound healing, delayed re-epithelialization, and decreased keratinocyte migration.
 
Phenotype Images(3)
Interactions
Ppm1a interacts with 252 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process dephosphorylation, negative regulation of I-kappaB kinase/NF-kappaB signaling, ...
Component cytoplasm, cytosol, ...
Function calmodulin-dependent protein phosphatase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (78)    Tissues (20)    Images (22)
Theiler Stages: 20, 23, 28
Assay TypeResults
RNA in situ 64
Northern blot 14
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(20)
Microarray probesets(14)
Other database
links
Ensembl Gene ModelENSMUSG00000021096 (Evidence)
Entrez Gene19042 (Evidence)
DFCITC1574997, TC1579127, TC1624660, TC1658008, TC1662109, TC1667157, TC1731004, TC1735052
DoTSDT.101180715, DT.101344042, DT.101379561, DT.495292, DT.91328619, DT.97408867
NIA Mouse Gene IndexU014068
EC3.1.3.16
Consensus CDS ProjectCCDS25970.1
International Mouse Knockout Project StatusPpm1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19042 NCBI Gene Model | MGI Sequence Detail 33730 C57BL/6J ±  kb
transcript NM_008910 RefSeq | MGI Sequence Detail 2789 C57BL/6 
polypeptide P49443 UniProt | EBI | MGI Sequence Detail 382 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(10) UniProt(4)
Polymorphisms SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015655 Protein phosphatase 2C
InterPro IPR000222 Protein phosphatase 2C, manganese/magnesium aspartate binding site
InterPro IPR001932 Protein phosphatase 2C (PP2C)-like
InterPro IPR012911 Protein serine/threonine phosphatase 2C, C-terminal
Protein Ontology PR:000013090 protein phosphatase 1A
Graphical View of Protein Domain Structure
References (Earliest) J:19652 Kato S, et al., The cDNA sequence encoding mouse Mg2+ -dependent protein phosphatase alpha. Gene. 1994 Aug 5;145(2):311-2
(Latest) J:194018 Chida T, et al., N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells. Biochem J. 2013 Feb 1;449(3):741-9
All references(46)
Other
accession IDs
MGD-MRK-16669, MGI:1916736, MGI:1920167, MGI:2144816, MGI:2144943

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory