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Gdi1
Gene Detail
Symbol

Name
ID
Gdi1
guanosine diphosphate (GDP) dissociation inhibitor 1
MGI:99846
Synonyms
GDIA, MGC:21593, Rab GDIalpha
Feature Type
protein coding gene
Genetic Map
Chromosome X
37.97 cM, cytoband B-C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:74304998-74311862 bp, + strand
From VEGA annotation of GRCm38

  6865 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37487  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GDI1
Protein SuperFamily: GDP dissociation inhibitor XAP-4
Gene Tree: Gdi1

Human
homologs
GDI1, GDP dissociation inhibitor 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2664
neXtProt AC: NX_P31150

Human Synonyms: 1A, GDIL, MRX41, MRX48, OPHN2, RABGD1A, RABGDIA, XAP-4

Human Chr (Location): Xq28; chrX:154436913-154443467 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GDI1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
 
Males hemizygous for a reporter allele show lower male aggression, short-term memory defects, altered synaptic vesicle pools and short-term synaptic plasticity, and impaired glutamate release. Homozygotes for a null allele show enhanced paired-pulse facilitation and sensitivity to induced seizures.
 
Human Diseases Modeled in Mice Using Gdi1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Gdi1 interacts with 187 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (68)    Tissues (11)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 68
cDNA source data(251)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN gdi1    NEW 
Molecular
reagents
All nucleic(255) cDNA(255)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000017683 (Evidence)
Ensembl Gene Model ENSMUSG00000015291 (Evidence)
Entrez Gene 14567 (Evidence)
UniGene 205830
DFCI TC1573104, TC1592879, TC1606416
DoTS DT.101275250, DT.103586007, DT.87072890, DT.97407430, DT.99865116
NIA Mouse Gene Index U019958
Consensus CDS Project CCDS30227.1
International Mouse Phenotyping Consortium Status Gdi1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017683 VEGA Gene Model | MGI Sequence Detail 6865 C57BL/6J ±  kb
transcript OTTMUST00000042881 VEGA | MGI Sequence Detail 2666 Not Applicable 
polypeptide OTTMUSP00000019266 VEGA | MGI Sequence Detail 447 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018203 GDP dissociation inhibitor
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR000806 Rab GDI protein
Protein Ontology PR:000007926 rab GDP dissociation inhibitor alpha
References
(Earliest) J:17786 Shisheva A, et al., Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle. Mol Cell Biol. 1994 May;14(5):3459-68
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(44)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16637

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory