Gdi1
Gene Detail

Symbol Name ID

Gdi1 guanosine diphosphate (GDP) dissociation inhibitor 1 MGI:99846

Synonyms

GDIA, MGC:21593, Rab GDIalpha

Feature Type

protein coding gene

Genetic Map

Chromosome X

37.97 cM, cytoband B-C1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

ChrX:74304998-74311862 bp, + strand From VEGA annotation of GRCm38   6865 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37487  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Protein SuperFamily: GDP dissociation inhibitor XAP-4
Gene Tree: Gdi1

Human homologs

Human Homolog		GDI1, GDP dissociation inhibitor 1
NCBI Gene ID		2664
neXtProt AC		NX_P31150
Human Synonyms		1A, GDIL, MRX41, MRX48, OPHN2, RABGD1A, RABGDIA, XAP-4
Human Chr (Location)		Xq28; chrX:153665259-153671814 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GDI1

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Males hemizygous for a reporter allele show lower male aggression, short-term memory defects, altered synaptic vesicle pools and short-term synaptic plasticity, and impaired glutamate release. Homozygotes for a null allele show enhanced paired-pulse facilitation and sensitivity to induced seizures.

 
Human Diseases Modeled Using Mouse Gdi1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	negative regulation of axonogenesis, protein transport, ...
Component	cytoplasm, midbody, ...
Function	GTPase activator activity, Rab GDP-dissociation inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (68)    Tissues (11)    Images (20)
Theiler Stages: 23

Assay Type	Results
RNA in situ	68

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(15)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000017683 (Evidence)
Ensembl Gene Model	ENSMUSG00000015291 (Evidence)
Entrez Gene	14567 (Evidence)
DFCI	TC1573104, TC1592879, TC1606416
DoTS	DT.101275250, DT.103586007, DT.87072890, DT.97407430, DT.99865116
NIA Mouse Gene Index	U019958
Consensus CDS Project	CCDS30227.1
International Mouse Knockout Project Status	Gdi1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017683	VEGA Gene Model | MGI Sequence Detail	6865	C57BL/6J
transcript	OTTMUST00000042881	VEGA | MGI Sequence Detail	2666	Not Applicable
polypeptide	OTTMUSP00000019266	VEGA | MGI Sequence Detail	447	Not Applicable

All sequences(66) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(31 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018203	GDP dissociation inhibitor
InterPro	IPR000806	Rab GDI protein
Protein Ontology	PR:000007926	rab GDP dissociation inhibitor alpha

References

(Earliest) J:17786 Shisheva A, et al., Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle. Mol Cell Biol. 1994 May;14(5):3459-68
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(43)

Other accession IDs

MGD-MRK-16637