About   Help   FAQ
Gdi1 Gene Detail
Summary
  • Symbol
    Gdi1
  • Name
    guanosine diphosphate (GDP) dissociation inhibitor 1
  • Synonyms
    GDIA, MGC:21593, Rab GDIalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:99846
    NCBI Gene: 14567
  • Gene Overview
    MyGene.info: GDI1
Location & Maps
more
  • Sequence Map
    ChrX:74304998-74311862 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6865 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GDI1, GDP dissociation inhibitor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GDI1, GDP dissociation inhibitor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    1A, GDIL, MRX41, MRX48, OPHN2, RABGD1A, RABGDIA, XAP-4
  • Links
    NCBI Gene ID: 2664
    neXtProt AC: NX_P31150

  • Chr Location
    Xq28; chrX:154436913-154443467 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Gdi1 mouse models; 1 with human GDI1 associations

Human Disease Mouse Models
       Mental Retardation, X-Linked 41; MRX41   OMIM: 300849 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Gene trapped
    2
  • Targeted
    3
Males hemizygous for a reporter allele show lower male aggression, short-term memory defects, altered synaptic vesicle pools and short-term synaptic plasticity, and impaired glutamate release. Homozygotes for a null allele show enhanced paired-pulse facilitation and sensitivity to induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017683 VEGA Gene Model | MGI Sequence Detail 6865 C57BL/6J ±  kb
transcript OTTMUST00000042881 VEGA | MGI Sequence Detail 2666 Not Applicable  
polypeptide OTTMUSP00000019266 VEGA | MGI Sequence Detail 447 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    40 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 255
    cDNA 255

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16637
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:17786 Shisheva A, et al., Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle. Mol Cell Biol. 1994 May;14(5):3459-68
  • Latest
    J:224063 Bianchi V, et al., Forebrain deletion of alphaGDI in adult mice worsens the pre-synaptic deficit at cortico-lateral amygdala synaptic connections. PLoS One. 2012;7(1):e29763

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/26/2016
MGI 6.03
The Jackson Laboratory