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Gdi1
Gene Detail
 Symbol
Name
ID
Gdi1
guanosine diphosphate (GDP) dissociation inhibitor 1
MGI:99846
Synonyms GDIA, MGC:21593, Rab GDIalpha
Feature Type protein coding gene
Genetic Map
Chromosome X
37.97 cM, cytoband B-C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:74304998-74311862 bp, + strand
From VEGA annotation of GRCm38

  6865 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37487  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: GDP dissociation inhibitor XAP-4
Gene Tree: Gdi1

Human
homologs
Human Homolog GDI1, GDP dissociation inhibitor 1
NCBI Gene ID 2664
neXtProt AC  NX_P31150
Human Synonyms  1A, GDIL, MRX41, MRX48, OPHN2, RABGD1A, RABGDIA, XAP-4
Human Chr (Location)  Xq28; chrX:154436913-154443467 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GDI1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
 
Males hemizygous for a reporter allele show lower male aggression, short-term memory defects, altered synaptic vesicle pools and short-term synaptic plasticity, and impaired glutamate release. Homozygotes for a null allele show enhanced paired-pulse facilitation and sensitivity to induced seizures.
 
Human Diseases Modeled Using Mouse Gdi1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Gdi1 interacts with 187 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process negative regulation of axonogenesis, negative regulation of protein targeting to membrane, ...
Component cytoplasm, Golgi apparatus, ...
Function GTPase activator activity, Rab GDP-dissociation inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (68)    Tissues (11)    Images (20)
Theiler Stages: 23
Assay TypeResults
RNA in situ 68
cDNA source data(251)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(255) cDNA(255)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017683 (Evidence)
Ensembl Gene ModelENSMUSG00000015291 (Evidence)
Entrez Gene14567 (Evidence)
UniGene205830
DFCITC1573104, TC1592879, TC1606416
DoTSDT.101275250, DT.103586007, DT.87072890, DT.97407430, DT.99865116
NIA Mouse Gene IndexU019958
Consensus CDS ProjectCCDS30227.1
International Mouse Knockout Project StatusGdi1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017683 VEGA Gene Model | MGI Sequence Detail 6865 C57BL/6J ±  kb
transcript OTTMUST00000042881 VEGA | MGI Sequence Detail 2666 Not Applicable 
polypeptide OTTMUSP00000019266 VEGA | MGI Sequence Detail 447 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018203 GDP dissociation inhibitor
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR000806 Rab GDI protein
Protein Ontology PR:000007926 rab GDP dissociation inhibitor alpha
References (Earliest) J:17786 Shisheva A, et al., Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle. Mol Cell Biol. 1994 May;14(5):3459-68
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(44)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16637

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory