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Gem Gene Detail
Summary
  • Symbol
    Gem
  • Name
    GTP binding protein (gene overexpressed in skeletal muscle)
  • Feature Type
    protein coding gene
  • IDs
    MGI:99844
    NCBI Gene: 14579
  • Gene Overview
    MyGene.info: GEM
Location & Maps
more
  • Sequence Map
    Chr4:11704457-11714752 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10296 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 5.34 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    GEM, GTP binding protein overexpressed in skeletal muscle
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GEM, GTP binding protein overexpressed in skeletal muscle
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KIR
  • Links
    NCBI Gene ID: 2669
    neXtProt AC: NX_P55040

  • Chr Location
    8q13-q21; chr8:94249253-94262319 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    4
  • Transgenic
    1
Mice homozygous for a knock-out allele exhibit impaired glucose tolerance, decreased insulin secretion and abnormal calcium handling in pancreatic beta-cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004518 VEGA Gene Model | MGI Sequence Detail 10296 C57BL/6J ±  kb
transcript OTTMUST00000010236 VEGA | MGI Sequence Detail 2006 Not Applicable  
polypeptide OTTMUSP00000004868 VEGA | MGI Sequence Detail 295 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    103 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007932 GTP-binding protein GEM
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase superfamily
    IPR017358 Small GTPase superfamily, GEM/REM/Rad
    IPR020849 Small GTPase superfamily, Ras type
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
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  • All nucleic 23
    Genomic 1
    cDNA 22

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-16635, MGI:2140514
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:19208 Maguire J, et al., Gem: an induced, immediate early protein belonging to the Ras family. Science. 1994 Jul 8;265(5169):241-4
  • Latest
    J:215309 Patterson ES, et al., Geminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation. Dev Biol. 2014 Sep 1;393(1):44-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory