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Gem Gene Detail
Summary
  • Symbol
    Gem
  • Name
    GTP binding protein (gene overexpressed in skeletal muscle)
  • Feature Type
    protein coding gene
  • IDs
    MGI:99844
    NCBI Gene: 14579
  • Gene Overview
    MyGene.info: GEM
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:11704457-11714752 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 5.34 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    103 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99844
protein coding gene Chr4:11704447-11714993 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028056
protein coding gene Chr4:8389113-8399393 (+)
A/J MGP_AJ_G0028013
protein coding gene Chr4:8249335-8259768 (+)
AKR/J MGP_AKRJ_G0027979
protein coding gene Chr4:8345548-8355845 (+)
BALB/cJ MGP_BALBcJ_G0028025
protein coding gene Chr4:8172919-8183212 (+)
C3H/HeJ MGP_C3HHeJ_G0027755
protein coding gene Chr4:8519142-8529433 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028468
protein coding gene Chr4:8800076-8811122 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025812
protein coding gene Chr4:7771790-7782290 (+)
CAST/EiJ MGP_CASTEiJ_G0027209
protein coding gene Chr4:8337564-8347959 (+)
CBA/J MGP_CBAJ_G0027730
protein coding gene Chr4:9052678-9062969 (+)
DBA/2J MGP_DBA2J_G0027871
protein coding gene Chr4:8115416-8125696 (+)
FVB/NJ MGP_FVBNJ_G0027837
protein coding gene Chr4:7945914-7955199 (+)
LP/J MGP_LPJ_G0027981
protein coding gene Chr4:8468397-8478668 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027870
protein coding gene Chr4:9224847-9238911 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028527
protein coding gene Chr4:8346530-8356832 (+)
PWK/PhJ MGP_PWKPhJ_G0026930
protein coding gene Chr4:8134820-8145300 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026760
protein coding gene Chr4:8263941-8274217 (+)
WSB/EiJ MGP_WSBEiJ_G0027288
protein coding gene Chr4:8412230-8422527 (+)



Homology
more
  • Human Ortholog
    GEM, GTP binding protein overexpressed in skeletal muscle
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GEM, GTP binding protein overexpressed in skeletal muscle
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIR
  • Links
    NCBI Gene ID: 2669
    neXtProt AC: NX_P55040
    UniProt: P55040

  • Chr Location
    8q22.1; chr8:94249249-94262345 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired glucose tolerance, decreased insulin secretion and abnormal calcium handling in pancreatic beta-cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028214 Ensembl Gene Model | MGI Sequence Detail 10296 C57BL/6J ±  kb
transcript ENSMUST00000108304 Ensembl | MGI Sequence Detail 2006 Not Applicable  
polypeptide ENSMUSP00000103939 Ensembl | MGI Sequence Detail 295 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    Genomic 1
    cDNA 23

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16635, MGI:2140514
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 5
  • Earliest
    J:19208 Maguire J, et al., Gem: an induced, immediate early protein belonging to the Ras family. Science. 1994 Jul 8;265(5169):241-4
  • Latest
    J:231595 Gurdziel K, et al., Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory