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Gem
Gene Detail
 Symbol
Name
ID
Gem
GTP binding protein (gene overexpressed in skeletal muscle)
MGI:99844
Feature Type protein coding gene
Genetic Map
Chromosome 4
5.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr4:11704457-11714752 bp, + strand
From VEGA annotation of GRCm38

  10296 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38024  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: GTP-binding protein, GEM type
Gene Tree: Gem

Human
homologs
Human Homolog GEM, GTP binding protein overexpressed in skeletal muscle
NCBI Gene ID 2669
neXtProt AC  NX_P55040
Human Synonyms  KIR
Human Chr (Location)  8q13-q21; chr8:94249253-94262319 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Mice homozygous for a knock-out allele exhibit impaired glucose tolerance, decreased insulin secretion and abnormal calcium handling in pancreatic beta-cells.
 
Interactions
Gem interacts with 139 markers (Mir17, Mir20b, Mir30a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process chromosome organization, GTP catabolic process, ...
Component cytoplasmic side of plasma membrane, membrane, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (69)    Tissues (12)    Images (21)
Theiler Stages: 23
Assay TypeResults
RNA in situ 69
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(22)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000004518 (Evidence)
Ensembl Gene ModelENSMUSG00000028214 (Evidence)
Entrez Gene14579 (Evidence)
UniGene247486
DFCITC1578890, TC1766888
DoTSDT.110790872, DT.528706, DT.97385810
NIA Mouse Gene IndexU004071
Consensus CDS ProjectCCDS17971.1
International Mouse Knockout Project StatusGem
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004518 VEGA Gene Model | MGI Sequence Detail 10296 C57BL/6J ±  kb
transcript OTTMUST00000010236 VEGA | MGI Sequence Detail 2006 Not Applicable 
polypeptide OTTMUSP00000004868 VEGA | MGI Sequence Detail 295 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(103 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR017358 Small GTPase superfamily, GEM/REM/Rad
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000007932 GTP-binding protein GEM
References (Earliest) J:19208 Maguire J, et al., Gem: an induced, immediate early protein belonging to the Ras family. Science. 1994 Jul 8;265(5169):241-4
(Latest) J:209053 Hoekstra EJ, et al., Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons. Eur J Neurosci. 2013 Jan;37(1):23-32
All references(41)
Other
accession IDs
MGD-MRK-16635, MGI:2140514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory