Htr1f
Gene Detail

Symbol Name ID

Htr1f 5-hydroxytryptamine (serotonin) receptor 1F MGI:99842

Synonyms

Htr1eb

Feature Type

protein coding gene

Genetic Map

Chromosome 16

37.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr16:64924729-65105784 bp, - strand From NCBI annotation of GRCm38   181056 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37361  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 5-hydroxytryptamine receptor 1
Gene Tree: Htr1f

Human homologs

Human Homolog		HTR1F, 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
NCBI Gene ID		3355
neXtProt AC		NX_P30939
Human Synonyms		5-HT1F, 5-HT-1F, 5HT6, HTR1EL, MR77
Human Chr (Location)		3p12; chr3:88031726-88042919 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for disruptions in this gene display decreased temperature sensitivity and physiological abnormalities in nerve fibers.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	behavior, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	G-protein coupled receptor activity, serotonin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (280)    Tissues (97)    Images (37)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	43
In situ reporter (knock in)	61
RT-PCR	176

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(6) Primer pair(3)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000050783 (Evidence)
Entrez Gene	15557 (Evidence)
UniGene	5040
DFCI	TC1589072
DoTS	DT.91335485
NIA Mouse Gene Index	U037178
Consensus CDS Project	CCDS28267.1
International Mouse Knockout Project Status	Htr1f

Sequences

Length	Strain/Species
genomic	15557	NCBI Gene Model | MGI Sequence Detail	181056	C57BL/6J
transcript	NM_008310	RefSeq | MGI Sequence Detail	2509	C57BL/6
polypeptide	Q02284	UniProt | EBI | MGI Sequence Detail	366	Not Applicable

All sequences(16) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(600 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000450	5-Hydroxytryptamine 1F receptor
InterPro	IPR002231	5-Hydroxytryptamine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001165	5-hydroxytryptamine receptor 1F

Graphical View of Protein Domain Structure

References

(Earliest) J:2640 Amlaiky N, et al., Isolation of a mouse 5HT1E-like serotonin receptor expressed predominantly in hippocampus. J Biol Chem. 1992 Oct 5;267(28):19761-4
(Latest) J:162220 Magdaleno S, et al., BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
All references(33)

Other accession IDs

MGD-MRK-11006, MGD-MRK-16633, MGI:96280