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Htr1f Gene Detail
Summary
  • Symbol
    Htr1f
  • Name
    5-hydroxytryptamine (serotonin) receptor 1F
  • Synonyms
    Htr1eb
  • Feature Type
    protein coding gene
  • IDs
    MGI:99842
    NCBI Gene: 15557
  • Gene Overview
    MyGene.info: HTR1F
Location & Maps
more
  • Sequence Map
    Chr16:64924729-65105784 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      181056 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 37.10 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    HTR1F, 5-hydroxytryptamine receptor 1F
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HTR1F, 5-hydroxytryptamine receptor 1F
    Orthology source: HomoloGene, HGNC
  • Synonyms
    5-HT1F, 5-HT-1F, 5HT6, HTR1EL, MR77
  • Links
    NCBI Gene ID: 3355
    neXtProt AC: NX_P30939

  • Chr Location
    3p12; chr3:87792767-87994856 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display decreased temperature sensitivity and physiological abnormalities in nerve fibers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050783 Ensembl Gene Model | MGI Sequence Detail 181056 C57BL/6J ±  kb
transcript ENSMUST00000063076 Ensembl | MGI Sequence Detail 2509 Not Applicable  
polypeptide ENSMUSP00000063136 Ensembl | MGI Sequence Detail 366 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    714 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001165 5-hydroxytryptamine receptor 1F
  • InterPro Domains
    IPR000450 5-Hydroxytryptamine 1F receptor
    IPR002231 5-hydroxytryptamine receptor family
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 9
    cDNA 6
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11006, MGD-MRK-16633, MGI:96280
References
more
  • Summaries
    All 33
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:2640 Amlaiky N, et al., Isolation of a mouse 5HT1E-like serotonin receptor expressed predominantly in hippocampus. J Biol Chem. 1992 Oct 5;267(28):19761-4
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory