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Htr1f
Gene Detail
 Symbol
Name
ID
Htr1f
5-hydroxytryptamine (serotonin) receptor 1F
MGI:99842
Synonyms Htr1eb
Feature Type protein coding gene
Genetic Map
Chromosome 16
37.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr16:64924729-65105784 bp, - strand
From NCBI annotation of GRCm38

  181056 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37361  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 5-hydroxytryptamine receptor 1
Gene Tree: Htr1f

Human
homologs
Human Homolog HTR1F, 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
NCBI Gene ID 3355
neXtProt AC  NX_P30939
Human Synonyms  5-HT1F, 5-HT-1F, 5HT6, HTR1EL, MR77
Human Chr (Location)  3p12; chr3:87792779-87994814 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display decreased temperature sensitivity and physiological abnormalities in nerve fibers.
 
Interactions
Htr1f interacts with 183 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function G-protein coupled receptor activity, serotonin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (280)    Tissues (97)    Images (37)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 43
In situ reporter (knock in) 61
RT-PCR 176
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(6) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000050783 (Evidence)
Entrez Gene15557 (Evidence)
UniGene5040
DFCITC1589072
DoTSDT.91335485
NIA Mouse Gene IndexU037178
Consensus CDS ProjectCCDS28267.1
International Mouse Knockout Project StatusHtr1f
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15557 NCBI Gene Model | MGI Sequence Detail 181056 C57BL/6J ±  kb
transcript NM_008310 RefSeq | MGI Sequence Detail 2509 C57BL/6 
polypeptide Q02284 UniProt | EBI | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(722 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000450 5-Hydroxytryptamine 1F receptor
InterPro IPR002231 5-Hydroxytryptamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001165 5-hydroxytryptamine receptor 1F
Graphical View of Protein Domain Structure
References (Earliest) J:2640 Amlaiky N, et al., Isolation of a mouse 5HT1E-like serotonin receptor expressed predominantly in hippocampus. J Biol Chem. 1992 Oct 5;267(28):19761-4
(Latest) J:194270 Guadiana SM, et al., Arborization of dendrites by developing neocortical neurons is dependent on primary cilia and type 3 adenylyl cyclase. J Neurosci. 2013 Feb 6;33(6):2626-38
All references(35)
Other
accession IDs
MGD-MRK-11006, MGD-MRK-16633, MGI:96280

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory