Htr1f MGI Mouse Gene Detail - MGI:99842 - 5-hydroxytryptamine (serotonin) receptor 1F

Symbol

Htr1f
Name

5-hydroxytryptamine (serotonin) receptor 1F
Synonyms

Htr1eb

Feature Type

protein coding gene
IDs

MGI:99842
NCBI Gene: 15557
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr16:64745092-64926147 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 37.10 cM
Mapping Data

4 experiments

SNPs within 2kb

714 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99842	protein coding gene	Chr16:64745092-64926217 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022943	protein coding gene	Chr16:64431385-64625777 (-)
A/J	MGP_AJ_G0022911	protein coding gene	Chr16:61685336-61857104 (-)
AKR/J	MGP_AKRJ_G0022881	protein coding gene	Chr16:63570774-63750496 (-)
BALB/cJ	MGP_BALBcJ_G0022913	protein coding gene	Chr16:61890803-62059884 (-)
C3H/HeJ	MGP_C3HHeJ_G0022675	protein coding gene	Chr16:63916642-64083121 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023361	protein coding gene	Chr16:66374668-66577413 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020864	protein coding gene	Chr16:60730310-60872964 (-)
CAST/EiJ	MGP_CASTEiJ_G0022198	protein coding gene	Chr16:64160504-64321759 (-)
CBA/J	MGP_CBAJ_G0022646	protein coding gene	Chr16:69162484-69354537 (-)
DBA/2J	MGP_DBA2J_G0022778	protein coding gene	Chr16:61442451-61615332 (-)
FVB/NJ	MGP_FVBNJ_G0022752	protein coding gene	Chr16:61073113-61235834 (-)
LP/J	MGP_LPJ_G0022847	protein coding gene	Chr16:64240818-64427108 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022771	protein coding gene	Chr16:70392408-70578421 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023377	protein coding gene	Chr16:63713390-63876786 (-)
PWK/PhJ	MGP_PWKPhJ_G0021941	protein coding gene	Chr16:61606501-61775213 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021770	protein coding gene	Chr16:63403360-63566258 (-)
WSB/EiJ	MGP_WSBEiJ_G0022245	protein coding gene	Chr16:63774184-63949515 (-)

Human Ortholog

HTR1F, 5-hydroxytryptamine receptor 1F

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HTR1F, 5-hydroxytryptamine receptor 1F
Synonyms

5-HT1F, 5-HT-1F, 5HT6, HTR1EL, MR77
Links

HGNC:5292

NCBI Gene ID: 3355

neXtProt AC: NX_P30939

UniProt: P30939
Chr Location

3p11.2-p11.1; chr3:87792706-87993839 (+) GRCh38

MGI Vertebrate Homology

Htr1f stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HTR1F
Gene Tree

Htr1f

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display decreased temperature sensitivity and physiological abnormalities in nerve fibers.

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1112
Tissues

170
cDNA Data

7
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN htr1fa, htr1fb

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS28267.1

Ensembl

ENSMUSG00000050783 (Evidence)
NCBI Gene

15557

			Length	Strain/Species	Flank
genomic	15557	NCBI Gene Model \| MGI Sequence Detail	181056	C57BL/6J	± kb
transcript	NM_008310	RefSeq \| MGI Sequence Detail	2509	ZRU/MplStud
polypeptide	Q02284	UniProt \| EBI \| MGI Sequence Detail	366	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001165 5-hydroxytryptamine receptor 1F

(term hierarchy)
InterPro Domains

IPR000450 5-Hydroxytryptamine 1F receptor

IPR002231 5-hydroxytryptamine receptor family

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

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All nucleic 14

cDNA 8

Primer pair 6

Microarray probesets 4

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MGD-MRK-11006, MGD-MRK-16633, MGI:96280

Summaries

All 42

Developmental Gene Expression 8

Gene Ontology 5

Phenotypes 10
Earliest

J:2640 Amlaiky N, et al., Isolation of a mouse 5HT1E-like serotonin receptor expressed predominantly in hippocampus. J Biol Chem. 1992 Oct 5;267(28):19761-4
Latest

J:325980 Zhu P, et al., 5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis. Neuron. 2022 May 7;

TSS for Htr1f:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr141688	Chr16:64926076-64926090 (-)	64 bp
Tssr141687	Chr16:64926034-64926042 (-)	109 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23