About   Help   FAQ
Htr7
Gene Detail
 Symbol
Name
ID
Htr7
5-hydroxytryptamine (serotonin) receptor 7
MGI:99841
Synonyms 5-HT7
Feature Type protein coding gene
Genetic Map
Chromosome 19
30.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:35958734-36057507 bp, - strand
From VEGA annotation of GRCm38

  98774 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20244  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: 5-hydroxytryptamine receptor 7
Gene Tree: Htr7

Human
homologs
Human Homolog HTR7, 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
NCBI Gene ID 3363
neXtProt AC  NX_P34969
Human Synonyms  5-HT7
Human Chr (Location)  10q21-q24; chr10:90740818-90857914 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display lower electrically- and chemically-induced seizure thresholds. Mice homozygous for a different knock-out allele show enhanced coordination and higher thermal nociceptive thresholds. Other nullizygous mutantsfail to exhibit agonist-induced hypothermia.
 
Interactions
Htr7 interacts with 348 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process adenylate cyclase-activating serotonin receptor signaling pathway, behavioral response to pain, ...
Component axon terminus, dendrite, ...
Function G-protein coupled receptor activity, neurotransmitter receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (175)    Tissues (70)    Images (20)
Theiler Stages: 23, 28
Assay TypeResults
In situ reporter (knock in) 45
RT-PCR 130
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(11) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035906 (Evidence)
Ensembl Gene ModelENSMUSG00000024798 (Evidence)
Entrez Gene15566 (Evidence)
UniGene254266
DFCITC1587564, TC1618943, TC1681908
DoTSDT.102555320, DT.60101702, DT.99842690
NIA Mouse Gene IndexU038993
Consensus CDS ProjectCCDS29769.1
International Mouse Knockout Project StatusHtr7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035906 VEGA Gene Model | MGI Sequence Detail 98774 C57BL/6J ±  kb
transcript OTTMUST00000092099 VEGA | MGI Sequence Detail 1606 Not Applicable 
polypeptide OTTMUSP00000050824 VEGA | MGI Sequence Detail 470 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(10) UniProt(8)
Polymorphisms RFLP(1) : SNPs within 2kb(383 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001069 5-Hydroxytryptamine 7 receptor
InterPro IPR002231 5-Hydroxytryptamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001103 5-hydroxytryptamine receptor 7
References (Earliest) J:20576 Lovenberg TW, et al., A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Neuron. 1993 Sep;11(3):449-58
(Latest) J:195495 Kim JJ, et al., Targeted Inhibition of Serotonin Type 7 (5-HT7) Receptor Function Modulates Immune Responses and Reduces the Severity of Intestinal Inflammation. J Immunol. 2013 May 1;190(9):4795-804
All references(52)
Other
accession IDs
MGD-MRK-16632

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/26/2014
MGI 5.19
The Jackson Laboratory