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Htr7 Gene Detail
Summary
  • Symbol
    Htr7
  • Name
    5-hydroxytryptamine (serotonin) receptor 7
  • Synonyms
    5-HT7
  • Feature Type
    protein coding gene
  • IDs
    MGI:99841
    NCBI Gene: 15566
  • Gene Overview
    MyGene.info: HTR7
Location & Maps
more
  • Sequence Map
    Chr19:35958734-36057507 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      98774 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 30.30 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HTR7, 5-hydroxytryptamine receptor 7
  • Vertebrate Orthologs
    11
  • Human Ortholog
    HTR7, 5-hydroxytryptamine receptor 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    5-HT7
  • Links
    NCBI Gene ID: 3363
    neXtProt AC: NX_P34969

  • Chr Location
    10q21-q24; chr10:90740818-90857914 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 4 alleles in 4 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display lower electrically- and chemically-induced seizure thresholds. Mice homozygous for a different knock-out allele show enhanced coordination and higher thermal nociceptive thresholds. Other nullizygous mutantsfail to exhibit agonist-induced hypothermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035906 VEGA Gene Model | MGI Sequence Detail 98774 C57BL/6J ±  kb
transcript OTTMUST00000092099 VEGA | MGI Sequence Detail 1606 Not Applicable  
polypeptide OTTMUSP00000050824 VEGA | MGI Sequence Detail 470 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    361 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000001103 5-hydroxytryptamine receptor 7
  • InterPro Domains
    IPR001069 5-Hydroxytryptamine 7 receptor
    IPR002231 5-hydroxytryptamine receptor family
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 15
    cDNA 11
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-16632
References
more
  • Summaries
    All 50
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 17
  • Earliest
    J:20576 Lovenberg TW, et al., A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Neuron. 1993 Sep;11(3):449-58
  • Latest
    J:227435 Morita T, et al., HTR7 Mediates Serotonergic Acute and Chronic Itch. Neuron. 2015 Jul 1;87(1):124-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory