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Htr7 Gene Detail
Summary
  • Symbol
    Htr7
  • Name
    5-hydroxytryptamine (serotonin) receptor 7
  • Synonyms
    5-HT7
  • Feature Type
    protein coding gene
  • IDs
    MGI:99841
    NCBI Gene: 15566
  • Gene Overview
    MyGene.info: HTR7
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr19:35958734-36057507 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 30.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    361 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99841
protein coding gene Chr19:35958415-36058287 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025068
protein coding gene Chr19:34802212-34903611 (-)
A/J MGP_AJ_G0025044
protein coding gene Chr19:33125345-33230066 (-)
AKR/J MGP_AKRJ_G0025012
protein coding gene Chr19:34250018-34351865 (-)
BALB/cJ MGP_BALBcJ_G0025042
protein coding gene Chr19:33220956-33326932 (-)
C3H/HeJ MGP_C3HHeJ_G0024801
protein coding gene Chr19:34318904-34423318 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025483
protein coding gene Chr19:35816505-35919486 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022901
protein coding gene Chr19:32520977-32615366 (-)
CAST/EiJ MGP_CASTEiJ_G0024268
protein coding gene Chr19:34097069-34199497 (-)
CBA/J MGP_CBAJ_G0024778
protein coding gene Chr19:37502674-37620850 (-)
DBA/2J MGP_DBA2J_G0024910
protein coding gene Chr19:33007811-33105144 (-)
FVB/NJ MGP_FVBNJ_G0024871
protein coding gene Chr19:32818409-32913306 (-)
LP/J MGP_LPJ_G0024996
protein coding gene Chr19:34901044-34998664 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024902
protein coding gene Chr19:37334332-37459103 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025541
protein coding gene Chr19:34330084-34431645 (-)
PWK/PhJ MGP_PWKPhJ_G0024020
protein coding gene Chr19:32807225-32912962 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023820
protein coding gene Chr19:33177074-33276941 (-)
WSB/EiJ MGP_WSBEiJ_G0024335
protein coding gene Chr19:34430143-34534475 (-)



Homology
more
  • Human Ortholog
    HTR7, 5-hydroxytryptamine receptor 7
  • Vertebrate Orthologs
    11
  • Human Ortholog
    HTR7, 5-hydroxytryptamine receptor 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    5-HT7
  • Links
    NCBI Gene ID: 3363
    neXtProt AC: NX_P34969
    UniProt: P34969

  • Chr Location
    10q23.31; chr10:90740818-90857914 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 4 alleles in 4 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display lower electrically- and chemically-induced seizure thresholds. Mice homozygous for a different knock-out allele show enhanced coordination and higher thermal nociceptive thresholds. Other nullizygous mutantsfail to exhibit agonist-induced hypothermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024798 Ensembl Gene Model | MGI Sequence Detail 98774 C57BL/6J ±  kb
transcript ENSMUST00000099505 Ensembl | MGI Sequence Detail 1606 Not Applicable  
polypeptide ENSMUSP00000097105 Ensembl | MGI Sequence Detail 470 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 1
    cDNA 11
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16632
References
more
  • Summaries
    All 61
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 20
  • Earliest
    J:20576 Lovenberg TW, et al., A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Neuron. 1993 Sep;11(3):449-58
  • Latest
    J:254023 Bijata M, et al., Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix. Cell Rep. 2017 May 30;19(9):1767-1782

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory