Htr7
Gene Detail

Symbol Name ID

Htr7 5-hydroxytryptamine (serotonin) receptor 7 MGI:99841

Synonyms

5-HT7

Feature Type

protein coding gene

Genetic Map

Chromosome 19

30.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr19:35958734-36057507 bp, - strand From VEGA annotation of GRCm38   98774 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Htr7 ± 2 cM)

Protein SuperFamily: 5-hydroxytryptamine receptor 7
Gene Tree: Htr7

Human ortholog

HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled NCBI Gene ID 3363
Human Synonyms: 5-HT7
Human Chr10:92500575-92617671 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Mice homozygous for a knock-out allele display lower electrically- and chemically-induced seizure thresholds. Mice homozygous for a different knock-out allele show enhanced coordination and higher thermal nociceptive thresholds. Other nullizygous mutants fail to exhibit agonist-induced hypothermia.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	adenylate cyclase-activating serotonin receptor signaling pathway, behavioral response to pain, ...
Component	axon terminus, dendrite, ...
Function	G-protein coupled receptor activity, neurotransmitter receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (175)    Tissues (70)    Images (20)
Theiler Stages: 23, 28

Assay Type	Results
In situ reporter (knock in)	45
RT-PCR	130

cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(11) Primer pair(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035906 (Evidence)
Ensembl Gene Model	ENSMUSG00000024798 (Evidence)
Entrez Gene	15566 (Evidence)
UniGene	254266
DFCI	TC1587564, TC1618943, TC1681908
DoTS	DT.102555320, DT.60101702, DT.99842690
NIA Mouse Gene Index	U038993
Consensus CDS Project	CCDS29769.1
International Mouse Knockout Project Status	Htr7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035906	VEGA Gene Model | MGI Sequence Detail	98774	C57BL/6J
transcript	OTTMUST00000092099	VEGA | MGI Sequence Detail	1606	Not Applicable
polypeptide	OTTMUSP00000050824	VEGA | MGI Sequence Detail	470	Not Applicable

All sequences(55) RefSeq(2) UniProt(8)

Polymorphisms

RFLP(1) : SNPs(183 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001069	5-Hydroxytryptamine 7 receptor
InterPro	IPR002231	5-Hydroxytryptamine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001103	5-hydroxytryptamine receptor 7

References

(Earliest) J:20576 Lovenberg TW, et al., A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Neuron. 1993 Sep;11(3):449-58
(Latest) J:184623 Hernandez LL, et al., Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals. Am J Physiol Endocrinol Metab. 2012 Apr;302(8):E1009-15
All references(49)

Other accession IDs

MGD-MRK-16632