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Mug1
Gene Detail
 Symbol
Name
ID
Mug1
murinoglobulin 1
MGI:99837
Feature Type protein coding gene
Genetic Map
Chromosome 6
57.52 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:121838541-121889057 bp, + strand
From VEGA annotation of GRCm38

  50517 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:110674  Vertebrate Homology Class
2 mouse; 4 rat

Protein SuperFamily: alpha-2-macroglobulin
Gene Tree: Mug1

Alleles
and
phenotypes
All alleles(2) : Targeted(2)
 
Mice homozygous for a knock-out allele are viable, fertile and phenotypically normal under standard conditions but show increased mortality in response to diet-induced acute pancreatitis along with hepatic cell necrosis and inflammatory infiltration, and increased plasma amylase and lipase levels.
 
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process embryo implantation, negative regulation of peptidase activity
Component extracellular region, extracellular space
Function endopeptidase inhibitor activity, peptidase inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (51)    Tissues (14)    Images (4)
Theiler Stages: 28
Assay TypeResults
Northern blot 51
cDNA source data(131)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(133) Genomic(2) cDNA(131)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000033687 (Evidence)
Ensembl Gene ModelENSMUSG00000059908 (Evidence)
Entrez Gene17836 (Evidence)
UniGene1311
DFCITC1576635
DoTSDT.101160503, DT.536638
NIA Mouse Gene IndexU007363
Consensus CDS ProjectCCDS39618.1
International Mouse Knockout Project StatusMug1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033687 VEGA Gene Model | MGI Sequence Detail 50517 C57BL/6J ±  kb
transcript OTTMUST00000084863 VEGA | MGI Sequence Detail 4657 Not Applicable 
polypeptide OTTMUSP00000045780 VEGA | MGI Sequence Detail 1476 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(187 from dbSNP Build 137)    SNPs within 2kb including multiple locations(211)
Protein-related
information
ResourceIDDescription
InterPro IPR001599 Alpha-2-macroglobulin
InterPro IPR019742 Alpha-2-macroglobulin, conserved site
InterPro IPR002890 Alpha-2-macroglobulin, N-terminal
InterPro IPR011625 Alpha-2-macroglobulin, N-terminal 2
InterPro IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming
InterPro IPR009048 Alpha-macroglobulin, receptor-binding
InterPro IPR011626 A-macroglobulin complement component
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
InterPro IPR010916 TonB box, conserved site
Protein Ontology PR:000010927 murinoglobulin-1
References (Earliest) J:20322 Saito A, et al., Murinoglobulin, a novel protease inhibitor from murine plasma. Isolation, characterization, and comparison with murine alpha-macroglobulin and human alpha-2-macroglobulin. J Biol Chem. 1985 Jan 25;260(2):775-81
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(31)
Other
accession IDs
MGD-MRK-16627

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory