Mug1
Gene Detail

Symbol Name ID

Mug1 murinoglobulin 1 MGI:99837

Feature Type

protein coding gene

Genetic Map

Chromosome 6

57.52 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr6:121838541-121889057 bp, + strand From VEGA annotation of GRCm38   50517 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:110674  Vertebrate Homology Class
2 mouse; 4 rat

Protein SuperFamily: alpha-2-macroglobulin
Gene Tree: Mug1

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a knock-out allele are viable, fertile and phenotypically normal under standard conditions but show increased mortality in response to diet-induced acute pancreatitis along with hepatic cell necrosis and inflammatory infiltration, and increased plasma amylase and lipase levels.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	negative regulation of peptidase activity
Component	extracellular region, extracellular space
Function	endopeptidase inhibitor activity, peptidase inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (51)    Tissues (14)    Images (4)
Theiler Stages: 28

Assay Type	Results
Northern blot	51

cDNA source data(131)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(133) Genomic(2) cDNA(131)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000033687 (Evidence)
Ensembl Gene Model	ENSMUSG00000059908 (Evidence)
Entrez Gene	17836 (Evidence)
UniGene	1311
DFCI	TC1576635
DoTS	DT.101160503, DT.536638
NIA Mouse Gene Index	U007363
Consensus CDS Project	CCDS39618.1
International Mouse Knockout Project Status	Mug1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033687	VEGA Gene Model | MGI Sequence Detail	50517	C57BL/6J
transcript	OTTMUST00000084863	VEGA | MGI Sequence Detail	4657	Not Applicable
polypeptide	OTTMUSP00000045780	VEGA | MGI Sequence Detail	1476	Not Applicable

All sequences(24) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(171 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001599	Alpha-2-macroglobulin
InterPro	IPR019742	Alpha-2-macroglobulin, conserved site
InterPro	IPR002890	Alpha-2-macroglobulin, N-terminal
InterPro	IPR011625	Alpha-2-macroglobulin, N-terminal 2
InterPro	IPR019565	Alpha-2-macroglobulin, thiol-ester bond-forming
InterPro	IPR009048	Alpha-macroglobulin, receptor-binding
InterPro	IPR011626	A-macroglobulin complement component
InterPro	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
InterPro	IPR010916	TonB box, conserved site
Protein Ontology	PR:000010927	murinoglobulin-1

References

(Earliest) J:20322 Saito A, et al., Murinoglobulin, a novel protease inhibitor from murine plasma. Isolation, characterization, and comparison with murine alpha-macroglobulin and human alpha-2-macroglobulin. J Biol Chem. 1985 Jan 25;260(2):775-81
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(31)

Other accession IDs

MGD-MRK-16627