Mug2
Gene Detail

Symbol Name ID

Mug2 murinoglobulin 2 MGI:99836

Feature Type

protein coding gene

Genetic Map

Chromosome 6

57.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr6:122006798-122085967 bp, + strand From NCBI annotation of GRCm38   79170 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:110674  Vertebrate Homology Class
2 mouse; 4 rat

Protein SuperFamily: alpha-2-macroglobulin
Gene Tree: Mug2

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	negative regulation of peptidase activity
Component	extracellular region, extracellular space
Function	endopeptidase inhibitor activity, peptidase inhibitor activity, ...

External Resources: FuncBase

Expression

cDNA source data(23)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(2) cDNA(23) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000030131 (Evidence)
Entrez Gene	17837 (Evidence)
UniGene	479223
DFCI	TC1587136
DoTS	DT.94286875
NIA Mouse Gene Index	U007365
Consensus CDS Project	CCDS39619.1
International Mouse Knockout Project Status	Mug2

Sequences

Length	Strain/Species
genomic	17837	NCBI Gene Model | MGI Sequence Detail	79170	C57BL/6J
transcript	NM_008646	RefSeq | MGI Sequence Detail	4544	Not Specified
polypeptide	P28666	UniProt | EBI | MGI Sequence Detail	1451	Not Applicable

All sequences(12) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(96 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001599	Alpha-2-macroglobulin
InterPro	IPR019742	Alpha-2-macroglobulin, conserved site
InterPro	IPR002890	Alpha-2-macroglobulin, N-terminal
InterPro	IPR011625	Alpha-2-macroglobulin, N-terminal 2
InterPro	IPR019565	Alpha-2-macroglobulin, thiol-ester bond-forming
InterPro	IPR009048	Alpha-macroglobulin, receptor-binding
InterPro	IPR011626	A-macroglobulin complement component
InterPro	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
InterPro	IPR010916	TonB box, conserved site
Protein Ontology	PR:000010928	murinoglobulin-2

Graphical View of Protein Domain Structure

References

(Earliest) J:15557 Van Leuven F, et al., The alpha-macroglobulin family of proteinase inhibitors and the A/LRP receptor. Fifth International Workshop on Mouse Genome Mapping. 1991;:55
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(24)

Other accession IDs

MGD-MRK-16626