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Slc7a2 Gene Detail
Summary
  • Symbol
    Slc7a2
  • Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
  • Synonyms
    Atrc2, Cat2, Tea
  • Feature Type
    protein coding gene
  • IDs
    MGI:99828
    NCBI Gene: 11988
  • Alliance
  • Transcription Start Sites
    108 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:41315404-41375107 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 23.89 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    688 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99828
protein coding gene Chr8:41315404-41375345 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033557
protein coding gene Chr8:39681268-39748356 (+)
A/J MGP_AJ_G0033540
protein coding gene Chr8:38171018-38235340 (+)
AKR/J MGP_AKRJ_G0033463
protein coding gene Chr8:39325545-39382792 (+)
BALB/cJ MGP_BALBcJ_G0033535
protein coding gene Chr8:38293987-38357973 (+)
C3H/HeJ MGP_C3HHeJ_G0033245
protein coding gene Chr8:39696441-39771578 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034051
protein coding gene Chr8:41202746-41265100 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031000
protein coding gene Chr8:34837538-34897015 (+)
CAST/EiJ MGP_CASTEiJ_G0032573
protein coding gene Chr8:39209808-39272403 (+)
CBA/J MGP_CBAJ_G0033223
protein coding gene Chr8:42904397-42971348 (+)
DBA/2J MGP_DBA2J_G0033377
protein coding gene Chr8:38010684-38070174 (+)
FVB/NJ MGP_FVBNJ_G0033321
protein coding gene Chr8:37594959-37657593 (+)
LP/J MGP_LPJ_G0033466
protein coding gene Chr8:39725756-39794091 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033363
protein coding gene Chr8:42667087-42729404 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034069
protein coding gene Chr8:39476160-39543861 (+)
PWK/PhJ MGP_PWKPhJ_G0032282
protein coding gene Chr8:37553780-37615822 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032114
protein coding gene Chr8:38651938-38712242 (+)
WSB/EiJ MGP_WSBEiJ_G0032688
protein coding gene Chr8:39693299-39757591 (+)



Homology
more
  • Human Ortholog
    SLC7A2, solute carrier family 7 member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC7A2, solute carrier family 7 member 2
  • Synonyms
    ATRC2, CAT2, CAT-2A, CAT-2B, HCAT2, SLC7A2A, SLC7A2B
  • Links
    NCBI Gene ID: 6542
    neXtProt AC: NX_P52569
    UniProt: P52569

  • Chr Location
    8p22; chr8:17494069-17570573 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null allele exhibit a marked reduction of nitric oxide production by cytokine-activated macrophages.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11988 NCBI Gene Model | MGI Sequence Detail 59704 C57BL/6J ±  kb
    transcript NM_007514 RefSeq | MGI Sequence Detail 7731 ZRU/MplStud  
    polypeptide P18581 UniProt | EBI | MGI Sequence Detail 657 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 3
      cDNA 57
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-14988, MGD-MRK-16615, MGI:2142468
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 3
      Gene Ontology 14
      Phenotypes 24
    • Earliest
      J:10562 MacLeod CL, et al., Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor. Mol Cell Biol. 1990 Jul;10(7):3663-74
    • Latest
      J:314677 Coburn LA, et al., Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis. Oncogene. 2019 Feb;38(7):1067-1079

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory