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Slc7a2 Gene Detail
Summary
  • Symbol
    Slc7a2
  • Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
  • Synonyms
    Atrc2, Cat2, Tea
  • Feature Type
    protein coding gene
  • IDs
    MGI:99828
    NCBI Gene: 11988
  • Gene Overview
    MyGene.info: SLC7A2
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:40862367-40922070 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 23.89 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    688 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99828
protein coding gene Chr8:40862367-40922308 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033557
protein coding gene Chr8:39681268-39748356 (+)
A/J MGP_AJ_G0033540
protein coding gene Chr8:38171018-38235340 (+)
AKR/J MGP_AKRJ_G0033463
protein coding gene Chr8:39325545-39382792 (+)
BALB/cJ MGP_BALBcJ_G0033535
protein coding gene Chr8:38293987-38357973 (+)
C3H/HeJ MGP_C3HHeJ_G0033245
protein coding gene Chr8:39696441-39771578 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034051
protein coding gene Chr8:41202746-41265100 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031000
protein coding gene Chr8:34837538-34897015 (+)
CAST/EiJ MGP_CASTEiJ_G0032573
protein coding gene Chr8:39209808-39272403 (+)
CBA/J MGP_CBAJ_G0033223
protein coding gene Chr8:42904397-42971348 (+)
DBA/2J MGP_DBA2J_G0033377
protein coding gene Chr8:38010684-38070174 (+)
FVB/NJ MGP_FVBNJ_G0033321
protein coding gene Chr8:37594959-37657593 (+)
LP/J MGP_LPJ_G0033466
protein coding gene Chr8:39725756-39794091 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033363
protein coding gene Chr8:42667087-42729404 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034069
protein coding gene Chr8:39476160-39543861 (+)
PWK/PhJ MGP_PWKPhJ_G0032282
protein coding gene Chr8:37553780-37615822 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032114
protein coding gene Chr8:38651938-38712242 (+)
WSB/EiJ MGP_WSBEiJ_G0032688
protein coding gene Chr8:39693299-39757591 (+)



Homology
more
  • Human Ortholog
    SLC7A2, solute carrier family 7 member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC7A2, solute carrier family 7 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATRC2, CAT2, HCAT2
  • Links
    NCBI Gene ID: 6542
    neXtProt AC: NX_P52569
    UniProt: P52569

  • Chr Location
    8p22; chr8:17494349-17570568 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null allele exhibit a marked reduction of nitric oxide production by cytokine-activated macrophages.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11988 NCBI Gene Model | MGI Sequence Detail 59704 C57BL/6J ±  kb
transcript NM_007514 RefSeq | MGI Sequence Detail 7731 C57BL/6  
polypeptide P18581 UniProt | EBI | MGI Sequence Detail 657 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 62
    Genomic 3
    cDNA 57
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-14988, MGD-MRK-16615, MGI:2142468
References
more
  • Summaries
    All 66
    Developmental Gene Expression 2
    Gene Ontology 14
    Phenotypes 17
  • Earliest
    J:10562 MacLeod CL, et al., Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor. Mol Cell Biol. 1990 Jul;10(7):3663-74
  • Latest
    J:245863 Singh K, et al., The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria. PLoS Pathog. 2016 Oct;12(10):e1005984

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory