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Slc7a2
Gene Detail
Symbol

Name
ID
Slc7a2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
MGI:99828
Synonyms
Atrc2, Cat2, Tea
Feature Type
protein coding gene
Genetic Map
Chromosome 8
23.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr8:40862396-40922308 bp, + strand
From VEGA annotation of GRCm38

  59913 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20659  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC7A2
Protein SuperFamily: amino acid transporter
Gene Tree: Slc7a2

Human
homologs
SLC7A2, solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6542
neXtProt AC: NX_P52569

Human Synonyms: ATRC2, CAT2, HCAT2

Human Chr (Location): 8p22; chr8:17497088-17570568 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(10) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null allele exhibit a marked reduction of nitric oxide production by cytokine-activated macrophages.
 
Interactions
Slc7a2 interacts with 472 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (108)    Tissues (24)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 93
RT-PCR 15
cDNA source data(54)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc7a2 ; ZFIN slc7a2    NEW 
Molecular
reagents
All nucleic(61) Genomic(3) cDNA(56) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000031635 (Evidence)
Ensembl Gene Model ENSMUSG00000031596 (Evidence)
Entrez Gene 11988 (Evidence)
UniGene 4676
DFCI TC1586409, TC1593516, TC1624473, TC1643245, TC1646025, TC1653398, TC1694724
DoTS DT.101366776, DT.110866863, DT.87072294, DT.94132186, DT.94397689
NIA Mouse Gene Index U009284
Consensus CDS Project CCDS22258.1, CCDS40327.1
International Mouse Phenotyping Consortium Status Slc7a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031635 VEGA Gene Model | MGI Sequence Detail 59913 C57BL/6J ±  kb
transcript OTTMUST00000078365 VEGA | MGI Sequence Detail 3681 Not Applicable 
polypeptide OTTMUSP00000041669 VEGA | MGI Sequence Detail 674 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(12) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(704 from dbSNP Build 137)    SNPs within 2kb including multiple locations(706)
Protein-related
information
ResourceIDDescription
InterPro IPR002293 Amino acid/polyamine transporter I
InterPro IPR029485 Cationic amino acid transporter, C-terminal
InterPro IPR004755 Cationic amino acid transport permease
Protein Ontology PR:000015198 low affinity cationic amino acid transporter 2
References
(Earliest) J:10562 MacLeod CL, et al., Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor. Mol Cell Biol. 1990 Jul;10(7):3663-74
(Latest) J:205084 Singh K, et al., Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 1;305(3):G225-40
All references(60)
Other
accession IDs
MGD-MRK-14988, MGD-MRK-16615, MGI:2142468

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory