Slc7a2
Gene Detail

Symbol Name ID

Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 MGI:99828

Synonyms

Atrc2, Cat2, Tea

Feature Type

protein coding gene

Genetic Map

Chromosome 8

23.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr8:40862396-40922308 bp, + strand From VEGA annotation of GRCm38   59913 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20659  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: amino acid transporter
Gene Tree: Slc7a2

Human homologs

Human Homolog		SLC7A2, solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
NCBI Gene ID		6542
neXtProt AC		NX_P52569
Human Synonyms		ATRC2, CAT2, HCAT2
Human Chr (Location)		8p22; chr8:17354597-17428077 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(13) : Targeted(3) Gene trapped(10)
 

Homozygotes for a targeted null allele exhibit a marked reduction of nitric oxide production by cytokine-activated macrophages.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	amino acid transmembrane transport, amino acid transport, ...
Component	cytoplasm, integral to membrane, ...
Function	amino acid transmembrane transporter activity, arginine transmembrane transporter activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (108)    Tissues (24)    Images (42)
Theiler Stages: 10, 12, 21, 23, 28

Assay Type	Results
RNA in situ	93
RT-PCR	15

cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(58) Genomic(3) cDNA(53) Primer pair(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000031635 (Evidence)
Ensembl Gene Model	ENSMUSG00000031596 (Evidence)
Entrez Gene	11988 (Evidence)
UniGene	4676
DFCI	TC1586409, TC1593516, TC1624473, TC1643245, TC1646025, TC1653398, TC1694724
DoTS	DT.101366776, DT.110866863, DT.87072294, DT.94132186, DT.94397689
NIA Mouse Gene Index	U009284
Consensus CDS Project	CCDS22258.1, CCDS40327.1
International Mouse Knockout Project Status	Slc7a2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031635	VEGA Gene Model | MGI Sequence Detail	59913	C57BL/6J
transcript	OTTMUST00000078365	VEGA | MGI Sequence Detail	3681	Not Applicable
polypeptide	OTTMUSP00000041669	VEGA | MGI Sequence Detail	674	Not Applicable

All sequences(68) RefSeq(4) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(438 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002293	Amino acid/polyamine transporter I
InterPro	IPR015606	Cationic amino acid transporter
InterPro	IPR004755	Cationic amino acid transport permease
Protein Ontology	PR:000015198	low affinity cationic amino acid transporter 2

References

(Earliest) J:10562 MacLeod CL, et al., Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor. Mol Cell Biol. 1990 Jul;10(7):3663-74
(Latest) J:187486 Singh K, et al., L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution. Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G1061-73
All references(63)

Other accession IDs

MGD-MRK-14988, MGD-MRK-16615, MGI:2142468