Slc7a2 Gene Detail

Summary

• Symbol
  Slc7a2
• Name
  solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
• Synonyms
  Atrc2, Cat2, Tea

• Feature Type
  protein coding gene
• IDs
  MGI:99828
  NCBI Gene: 11988
• Alliance
  genome feature page
• Transcription Start Sites
  108 TSS

Location &
Maps

• Sequence Map
  Chr8:41315404-41375107 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 8, 23.89 cM
• Mapping Data
  14 experiments

Strain
Comparison

• SNPs within 2kb
  1661 from dbSNP Build 142
• Strain Annotations
  19
• RFLP
  2

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99828	protein coding gene	Chr8:41315404-41375345 (+)
129S1/SvImJ	ENSMUSG00200007336	protein coding gene	Chr8:36373870-36433218 (+)
A/J	ENSMUSG00195005432	protein coding gene	Chr8:36866025-36925364 (+)
AKR/J	ENSMUSG00220005469	protein coding gene	Chr8:36670946-36730268 (+)
BALB/cJ	ENSMUSG00180003051	protein coding gene	Chr8:36410806-36470136 (+)
C3H/HeJ	ENSMUSG00175014059	protein coding gene	Chr8:36588794-36648126 (+)
C57BL/6NJ	ENSMUSG00215007624	protein coding gene	Chr8:36387773-36447693 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031000	protein coding gene	Chr8:34837538-34897015 (+)
CAST/EiJ	ENSTCUG00005005435	protein coding gene	Chr8:36505167-36564558 (+)
CBA/J	ENSMUSG00210012717	protein coding gene	Chr8:36428981-36488323 (+)
DBA/2J	ENSMUSG00185006009	protein coding gene	Chr8:42329508-42388824 (+)
FVB/NJ	ENSMUSG00205002206	protein coding gene	Chr8:35584159-35643491 (+)
JF1/MsJ	ENSUMUG00000012880	protein coding gene	Chr8:44048606-44108530 (+)
LP/J	ENSMUSG00230008872	protein coding gene	Chr8:45979276-46038602 (+)
NOD/ShiLtJ	ENSMUSG00190015297	protein coding gene	Chr8:36449796-36509110 (+)
NZO/HlLtJ	ENSMUSG00225014352	protein coding gene	Chr8:49622691-49682134 (+)
PWK/PhJ	ENSLUMG00010012608	protein coding gene	Chr8:36281210-36341729 (+)
SPRET/EiJ	ENSMSPG00010004252	protein coding gene	Chr8:37135501-37194197 (+)
WSB/EiJ	ENSIUOG00005004986	protein coding gene	Chr8:37326666-37386405 (+)

Homology

• Human Ortholog
  SLC7A2, solute carrier family 7 member 2

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  SLC7A2, solute carrier family 7 member 2
  
• Synonyms
  ATRC2, CAT2, CAT-2A, CAT-2B, HCAT2, SLC7A2A, SLC7A2B
• Links
  HGNC:11060

  NCBI Gene ID: 6542

  UniProt: P52569

  
  
• Chr Location
  8p22; chr8:17494069-17570573 (+)  GRCh38

---

• MGI Vertebrate Homology
  Slc7a2 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: SLC7A2
• Gene Tree
  Slc7a2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotypes from 2 alleles in 2 genetic backgrounds
  28 phenotype references
  

• All Mutations and Alleles
  19
• Endonuclease-mediated
  7
• Gene trapped
  8
• Targeted
  4
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  52 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Homozygotes for a targeted null allele exhibit a marked reduction of nitric oxide production by cytokine-activated macrophages.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  52
• GO References
  16

Expression

• Assay Results
  722
• Tissues
  31
• cDNA Data
  55
• Literature Summary
  3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase slc7a2
  ZFIN slc7a2

Sequences &
Gene Models

• All Sequences
  71
• RefSeq
  12
• UniProt
  3
• CCDS
  CCDS22258.1, CCDS40327.1

• Ensembl
  ENSMUSG00000031596 (Evidence)
• NCBI Gene
  11988

Representative Sequences			Length	Strain/Species
genomic	11988	NCBI Gene Model | MGI Sequence Detail	59704	C57BL/6J
transcript	NM_007514	RefSeq | MGI Sequence Detail	7731	ZRU/MplStud
polypeptide	P18581	UniProt | EBI | MGI Sequence Detail	657	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000015198 cationic amino acid transporter 2
  (term hierarchy)
• InterPro Domains
  IPR002293 Amino acid/polyamine transporter I
  IPR029485 Cationic amino acid transporter, C-terminal
  IPR004755 Cationic amino acid transport permease
• GlyGen
  P18581 4 sites

Molecular
Reagents

• All nucleic 62

  Genomic 3

  cDNA 57

  Primer pair 2

  
  

  Microarray probesets 7

Other
Accession IDs

MGD-MRK-14988, MGD-MRK-16615, MGI:2142468

References

• Summaries
  All 80

  Developmental Gene Expression 3

  Gene Ontology 16

  Phenotypes 28
• Earliest
  J:10562 MacLeod CL, et al., Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor. Mol Cell Biol. 1990 Jul;10(7):3663-74
• Latest
  J:381625 Coate KC, et al., Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners. Mol Metab. 2024 Oct 20;90:102050

TSS for Slc7a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76974	Chr8:41314866-41314880 (+)	-531 bp
Tssr76975	Chr8:41315219-41315287 (+)	-151 bp
Tssr76976	Chr8:41315298-41315309 (+)	-100 bp
Tssr76977	Chr8:41315416-41315467 (+)	38 bp
Tssr76978	Chr8:41315479-41315490 (+)	81 bp
Tssr76979	Chr8:41316146-41316194 (+)	766 bp
Tssr76980	Chr8:41316204-41316221 (+)	809 bp
Tssr76981	Chr8:41317331-41317346 (+)	1,935 bp
Tssr76982	Chr8:41319644-41319662 (+)	4,249 bp
Tssr76983	Chr8:41319753-41319772 (+)	4,359 bp
Tssr76984	Chr8:41322633-41322651 (+)	7,238 bp
Tssr76985	Chr8:41324323-41324355 (+)	8,935 bp
Tssr76986	Chr8:41327438-41327452 (+)	12,041 bp
Tssr76987	Chr8:41328668-41328677 (+)	13,269 bp
Tssr76988	Chr8:41330848-41330859 (+)	15,450 bp
Tssr76989	Chr8:41333140-41333162 (+)	17,747 bp
Tssr76990	Chr8:41335412-41335421 (+)	20,013 bp
Tssr76991	Chr8:41337690-41337702 (+)	22,292 bp
Tssr76992	Chr8:41337865-41337876 (+)	22,467 bp
Tssr76993	Chr8:41338637-41338680 (+)	23,255 bp
Tssr76994	Chr8:41339652-41339683 (+)	24,264 bp
Tssr76995	Chr8:41340889-41340900 (+)	25,491 bp
Tssr76996	Chr8:41340944-41340956 (+)	25,546 bp
Tssr76997	Chr8:41341053-41341070 (+)	25,658 bp
Tssr76998	Chr8:41341438-41341449 (+)	26,040 bp
Tssr76999	Chr8:41342562-41342576 (+)	27,165 bp
Tssr77000	Chr8:41343363-41343370 (+)	27,963 bp
Tssr77001	Chr8:41343502-41343512 (+)	28,103 bp
Tssr77002	Chr8:41343522-41343565 (+)	28,140 bp
Tssr77003	Chr8:41343643-41343655 (+)	28,245 bp
Tssr77004	Chr8:41343717-41343729 (+)	28,319 bp
Tssr77005	Chr8:41343741-41343754 (+)	28,344 bp
Tssr77006	Chr8:41343776-41343789 (+)	28,379 bp
Tssr77007	Chr8:41345290-41345317 (+)	29,900 bp
Tssr77008	Chr8:41345781-41345795 (+)	30,384 bp
Tssr77009	Chr8:41346734-41346745 (+)	31,336 bp
Tssr77010	Chr8:41347800-41347803 (+)	32,398 bp
Tssr77011	Chr8:41351967-41352003 (+)	36,581 bp
Tssr77012	Chr8:41352061-41352092 (+)	36,673 bp
Tssr77013	Chr8:41352113-41352127 (+)	36,716 bp
Tssr77014	Chr8:41352132-41352185 (+)	36,755 bp
Tssr77015	Chr8:41352193-41352211 (+)	36,798 bp
Tssr77016	Chr8:41352254-41352274 (+)	36,860 bp
Tssr77017	Chr8:41352307-41352339 (+)	36,919 bp
Tssr77018	Chr8:41353655-41353664 (+)	38,256 bp
Tssr77019	Chr8:41355531-41355560 (+)	40,142 bp
Tssr77020	Chr8:41355563-41355579 (+)	40,167 bp
Tssr77021	Chr8:41355581-41355627 (+)	40,200 bp
Tssr77022	Chr8:41357482-41357573 (+)	42,124 bp
Tssr77023	Chr8:41358607-41358657 (+)	43,228 bp
Tssr77024	Chr8:41358850-41358861 (+)	43,452 bp
Tssr77025	Chr8:41358897-41358908 (+)	43,499 bp
Tssr77026	Chr8:41359304-41359318 (+)	43,907 bp
Tssr77027	Chr8:41359644-41359647 (+)	44,242 bp
Tssr77028	Chr8:41359742-41359752 (+)	44,343 bp
Tssr77029	Chr8:41359910-41359922 (+)	44,512 bp
Tssr77030	Chr8:41360937-41360948 (+)	45,539 bp
Tssr77031	Chr8:41361083-41361202 (+)	45,739 bp
Tssr77032	Chr8:41361442-41361457 (+)	46,046 bp
Tssr77033	Chr8:41361705-41361716 (+)	46,307 bp
Tssr77034	Chr8:41361768-41361779 (+)	46,370 bp
Tssr77035	Chr8:41362699-41362713 (+)	47,302 bp
Tssr77036	Chr8:41363852-41363895 (+)	48,470 bp
Tssr77037	Chr8:41364047-41364102 (+)	48,671 bp
Tssr77038	Chr8:41365601-41365674 (+)	50,234 bp
Tssr77039	Chr8:41366995-41367037 (+)	51,612 bp
Tssr77040	Chr8:41367040-41367119 (+)	51,676 bp
Tssr77041	Chr8:41367948-41368032 (+)	52,586 bp
Tssr77042	Chr8:41368090-41368109 (+)	52,696 bp
Tssr77043	Chr8:41368685-41368702 (+)	53,290 bp
Tssr77044	Chr8:41368875-41368895 (+)	53,481 bp
Tssr77045	Chr8:41368897-41368918 (+)	53,504 bp
Tssr77046	Chr8:41369574-41369583 (+)	54,175 bp
Tssr77047	Chr8:41370189-41370194 (+)	54,788 bp
Tssr77048	Chr8:41370427-41370438 (+)	55,029 bp
Tssr77049	Chr8:41370562-41370569 (+)	55,162 bp
Tssr77050	Chr8:41370581-41370608 (+)	55,191 bp
Tssr77051	Chr8:41370619-41370630 (+)	55,221 bp
Tssr77052	Chr8:41370672-41370684 (+)	55,274 bp
Tssr77053	Chr8:41370685-41370750 (+)	55,314 bp
Tssr77054	Chr8:41370900-41370920 (+)	55,506 bp
Tssr77055	Chr8:41370941-41370952 (+)	55,543 bp
Tssr77056	Chr8:41371532-41371543 (+)	56,134 bp
Tssr77057	Chr8:41371549-41371560 (+)	56,151 bp
Tssr77058	Chr8:41371618-41371641 (+)	56,226 bp
Tssr77059	Chr8:41371799-41371813 (+)	56,402 bp
Tssr77060	Chr8:41372023-41372037 (+)	56,626 bp
Tssr77061	Chr8:41372057-41372068 (+)	56,659 bp
Tssr77062	Chr8:41372069-41372080 (+)	56,671 bp
Tssr77063	Chr8:41372094-41372232 (+)	56,759 bp
Tssr77064	Chr8:41372305-41372316 (+)	56,907 bp
Tssr77065	Chr8:41372531-41372551 (+)	57,137 bp
Tssr77066	Chr8:41372554-41372566 (+)	57,156 bp
Tssr77067	Chr8:41372597-41372608 (+)	57,199 bp
Tssr77068	Chr8:41372618-41372636 (+)	57,223 bp
Tssr77069	Chr8:41372652-41372671 (+)	57,258 bp
Tssr77070	Chr8:41372680-41372691 (+)	57,282 bp
Tssr77071	Chr8:41372710-41372759 (+)	57,331 bp
Tssr77072	Chr8:41372769-41372799 (+)	57,380 bp
Tssr77073	Chr8:41372814-41372838 (+)	57,422 bp
Tssr77074	Chr8:41372846-41372858 (+)	57,448 bp
Tssr77075	Chr8:41372868-41372886 (+)	57,473 bp
Tssr77076	Chr8:41373108-41373119 (+)	57,710 bp
Tssr77077	Chr8:41373373-41373408 (+)	57,987 bp
Tssr77078	Chr8:41373419-41373448 (+)	58,030 bp
Tssr77079	Chr8:41373893-41373910 (+)	58,498 bp
Tssr77080	Chr8:41374433-41374463 (+)	59,044 bp
Tssr77081	Chr8:41374856-41374869 (+)	59,459 bp