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Slc7a2
Gene Detail
 Symbol
Name
ID
Slc7a2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
MGI:99828
Synonyms Atrc2, Cat2, Tea
Feature Type protein coding gene
Genetic Map
Chromosome 8
23.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr8:40862396-40922308 bp, + strand
From VEGA annotation of GRCm38

  59913 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20659  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: amino acid transporter
Gene Tree: Slc7a2

Human
homologs
Human Homolog SLC7A2, solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
NCBI Gene ID 6542
neXtProt AC  NX_P52569
Human Synonyms  ATRC2, CAT2, HCAT2
Human Chr (Location)  8p22; chr8:17497088-17570568 (+)  GRCh38
Alleles
and
phenotypes
All alleles(13) : Targeted(3) Gene trapped(10)
 
Homozygotes for a targeted null allele exhibit a marked reduction of nitric oxide production by cytokine-activated macrophages.
 
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process amino acid transmembrane transport, amino acid transport, ...
Component integral component of membrane, membrane
Function amino acid transmembrane transporter activity, arginine transmembrane transporter activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (108)    Tissues (24)    Images (42)
Theiler Stages: 10, 12, 21, 23, 28
Assay TypeResults
RNA in situ 93
RT-PCR 15
cDNA source data(54)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(61) Genomic(3) cDNA(56) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000031635 (Evidence)
Ensembl Gene ModelENSMUSG00000031596 (Evidence)
Entrez Gene11988 (Evidence)
UniGene4676
DFCITC1586409, TC1593516, TC1624473, TC1643245, TC1646025, TC1653398, TC1694724
DoTSDT.101366776, DT.110866863, DT.87072294, DT.94132186, DT.94397689
NIA Mouse Gene IndexU009284
Consensus CDS ProjectCCDS22258.1, CCDS40327.1
International Mouse Knockout Project StatusSlc7a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031635 VEGA Gene Model | MGI Sequence Detail 59913 C57BL/6J ±  kb
transcript OTTMUST00000078365 VEGA | MGI Sequence Detail 3681 Not Applicable 
polypeptide OTTMUSP00000041669 VEGA | MGI Sequence Detail 674 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(12) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(704 from dbSNP Build 137)    SNPs within 2kb including multiple locations(706)
Protein-related
information
ResourceIDDescription
InterPro IPR002293 Amino acid/polyamine transporter I
InterPro IPR004755 Cationic amino acid transport permease
Protein Ontology PR:000015198 low affinity cationic amino acid transporter 2
References (Earliest) J:10562 MacLeod CL, et al., Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor. Mol Cell Biol. 1990 Jul;10(7):3663-74
(Latest) J:205084 Singh K, et al., Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 1;305(3):G225-40
All references(63)
Other
accession IDs
MGD-MRK-14988, MGD-MRK-16615, MGI:2142468

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory