Nt5e
Gene Detail

Symbol Name ID

Nt5e 5' nucleotidase, ecto MGI:99782

Synonyms

2210401F01Rik, CD73, ecto-5'-nucleotidase, Nt5

Feature Type

protein coding gene

Genetic Map

Chromosome 9

47.24 cM, cytoband E3.2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:88327609-88372089 bp, + strand From NCBI annotation of GRCm38   44481 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1895  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: UDP-sugar hydrolase/5'-nucleotidase/apyrase
Gene Tree: Nt5e

Human homologs

Human Homolog		NT5E, 5'-nucleotidase, ecto (CD73)
NCBI Gene ID		4907
neXtProt AC		NX_P21589
Human Synonyms		CD73, E5NT, eN, eNT, NT, NT5, NTE
Human Chr (Location)		6q14-q21; chr6:86159302-86205509 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NT5E

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice for one allele are viable and fertile with increased circulating alkaline phosphatase and impaired tubuloglomerular feedback regulation. Homozygous null mice for a second allele display increased vascular permeability especially under hypoxic conditions.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	adenosine biosynthetic process, adenosine metabolic process, ...
Component	anchored to membrane, cell surface, ...
Function	5'-nucleotidase activity, ferrous iron binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (304)    Tissues (140)    Images (30)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	212
RT-PCR	92

cDNA source data(42)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(45) cDNA(43) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000032420 (Evidence)
Entrez Gene	23959 (Evidence)
UniGene	244235
DFCI	TC1579035
DoTS	DT.482992, DT.97396526
NIA Mouse Gene Index	U010832
EC	3.1.3.5
Consensus CDS Project	CCDS23386.1
International Mouse Knockout Project Status	Nt5e

Sequences

Length	Strain/Species
genomic	23959	NCBI Gene Model | MGI Sequence Detail	44481	C57BL/6J
transcript	NM_011851	RefSeq | MGI Sequence Detail	3580	C57BL/6
polypeptide	Q61503	UniProt | EBI | MGI Sequence Detail	576	Not Applicable

All sequences(23) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(258 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006179	5'-Nucleotidase/apyrase
InterPro	IPR006146	5'-Nucleotidase, conserved site
InterPro	IPR008334	5'-Nucleotidase, C-terminal
InterPro	IPR004843	Metallophosphoesterase domain
Protein Ontology	PR:000001800	5'-nucleotidase

Graphical View of Protein Domain Structure

References

(Earliest) J:14604 Berkemeier LR, et al., Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron. 1991 Nov;7(5):857-66
(Latest) J:193320 Keller LV, et al., Restoring physiological cell heterogeneity in the mesenchyme during tooth engineering. Int J Dev Biol. 2012;56(9):737-46
All references(88)

Other accession IDs

MGD-MRK-16568, MGI:1921492, MGI:2143050