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Nt5e
Gene Detail
Symbol

Name
ID
Nt5e
5' nucleotidase, ecto
MGI:99782
Synonyms
2210401F01Rik, CD73, ecto-5'-nucleotidase, Nt5
Feature Type
protein coding gene
Genetic Map
Chromosome 9
47.24 cM, cytoband E3.2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:88327197-88372092 bp, + strand
From VEGA annotation of GRCm38

  44896 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1895  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NT5E
Protein SuperFamily: UDP-sugar hydrolase/5'-nucleotidase/apyrase
Gene Tree: Nt5e

Human
homologs
NT5E, 5'-nucleotidase, ecto (CD73)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4907
neXtProt AC: NX_P21589

Human Synonyms: CALJA, CD73, E5NT, eN, eNT, NT, NT5, NTE

Human Chr (Location): 6q14-q21; chr6:85449584-85495791 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NT5E

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice for one allele are viable and fertile with increased circulating alkaline phosphatase and impaired tubuloglomerular feedback regulation. Homozygous null mice for a second allele display increased vascular permeability especially under hypoxic conditions.
 
Interactions
Nt5e interacts with 319 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process adenosine biosynthetic process, adenosine metabolic process, ...
Component anchored component of membrane, cell surface, ...
Function 5'-nucleotidase activity, ferrous iron binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (304)    Tissues (140)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 212
RT-PCR 92
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) cDNA(43) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000045593 (Evidence)
Ensembl Gene Model ENSMUSG00000032420 (Evidence)
Entrez Gene 23959 (Evidence)
UniGene 244235
DFCI TC1579035
DoTS DT.482992, DT.97396526
NIA Mouse Gene Index U010832
EC 3.1.3.5
Consensus CDS Project CCDS23386.1
International Mouse Phenotyping Consortium Status Nt5e
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045593 VEGA Gene Model | MGI Sequence Detail 44896 C57BL/6J ±  kb
transcript OTTMUST00000119469 VEGA | MGI Sequence Detail 3995 Not Applicable 
polypeptide OTTMUSP00000066453 VEGA | MGI Sequence Detail 576 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(397 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006179 5'-Nucleotidase/apyrase
InterPro IPR006146 5'-Nucleotidase, conserved site
InterPro IPR008334 5'-Nucleotidase, C-terminal
InterPro IPR004843 Metallophosphoesterase domain
Protein Ontology PR:000001800 5'-nucleotidase
References
(Earliest) J:14604 Berkemeier LR, et al., Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron. 1991 Nov;7(5):857-66
(Latest) J:222646 Hou X, et al., Ecto-5'-nucleotidase (CD73) is involved in chronic cerebral hypoperfusion-induced white matter lesions and cognitive impairment by regulating glial cell activation and pro-inflammatory cytokines. Neuroscience. 2015 Jun 25;297:118-26
All references(109)
Other
accession IDs
MGD-MRK-16568, MGI:1921492, MGI:2143050

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory