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Kdm5c
Gene Detail
Symbol

Name
ID
Kdm5c
lysine (K)-specific demethylase 5C
MGI:99781
Synonyms
D930009K15Rik, Jarid1c, mKIAA0234, Smcx
Feature Type
protein coding gene
Genetic Map
Chromosome X
68.46 cM, cytoband F2-F4
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
ChrX:152233020-152274535 bp, + strand
From VEGA annotation of GRCm38

  41516 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:79498  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: histone H3 lysine 4 demethylase (Jumonji/ARID domain-containing protein)
Gene Tree: Kdm5c

Human
homologs
Human Homolog KDM5C, lysine (K)-specific demethylase 5C
NCBI Gene ID 8242
neXtProt AC  NX_P41229
Human Synonyms  DXS1272E, JARID1C, MRX13, MRXJ, MRXSCJ, MRXSJ, SMCX, XE169
Human Chr (Location)  Xp11.22-p11.21; chrX:53191321-53225422 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KDM5C
Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(33) Targeted(2)
 
Male chimeras hemizygous for a gene trapped allele exhibit posterior patterning defects and abnormal heart morphology at E9.5. Chimeras hemizygous for a different gene trapped allele appear normal at E10.5.
 
Phenotype Images(13)
Interactions
Kdm5c interacts with 294 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (17 records)
Data Summary: Results (90)    Tissues (58)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 33
Northern blot 23
RT-PCR 34
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) Genomic(4) cDNA(31) Primer pair(3) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000017219 (Evidence)
Ensembl Gene ModelENSMUSG00000025332 (Evidence)
Entrez Gene20591 (Evidence)
DFCITC1576232, TC1595543, TC1605761, TC1606659, TC1608719, TC1632120, TC1633083, TC1647688, TC1775787
DoTSDT.101738366, DT.102552114, DT.111074322, DT.40173784, DT.50315997, DT.91380845
NIA Mouse Gene IndexU043801, U349481
EC1.14.11.-
Consensus CDS ProjectCCDS41178.1
International Mouse Knockout Project StatusKdm5c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017219 VEGA Gene Model | MGI Sequence Detail 41516 C57BL/6J ±  kb
transcript OTTMUST00000041692 VEGA | MGI Sequence Detail 5900 Not Applicable 
polypeptide OTTMUSP00000018728 VEGA | MGI Sequence Detail 1554 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(14) UniProt(9)
Polymorphisms
RFLP(2) : SNPs within 2kb(130 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001606 ARID/BRIGHT DNA-binding domain
InterPro IPR003347 JmjC domain
InterPro IPR013637 Lysine-specific demethylase-like domain
InterPro IPR003349 Transcription factor jumonji, JmjN
InterPro IPR004198 Zinc finger, C5HC2-type
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR019786 Zinc finger, PHD-type, conserved site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000009206 lysine-specific demethylase 5C
References
(Earliest) J:18900 Agulnik AI, et al., A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens. Hum Mol Genet. 1994 Jun;3(6):873-8
(Latest) J:215367 Shao GB, et al., Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development. In Vitro Cell Dev Biol Anim. 2014 Aug;50(7):603-13
All references(71)
Other
accession IDs
MGD-MRK-16567, MGI:3026968

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory