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Kdm5d Gene Detail
Summary
  • Symbol
    Kdm5d
  • Name
    lysine (K)-specific demethylase 5D
  • Synonyms
    HY, Jarid1d, Smcy
  • Feature Type
    protein coding gene
  • IDs
    MGI:99780
    NCBI Gene: 20592
  • Gene Overview
    MyGene.info: KDM5D
Location & Maps
more
  • Genetic Map
    Chromosome Y, cytoband p
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    KDM5D, lysine demethylase 5D
  • Vertebrate Orthologs
    3
  • Human Ortholog
    KDM5D, lysine demethylase 5D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HY, HYA, JARID1D, SMCY
  • Links
    NCBI Gene ID: 8284
    neXtProt AC: NX_Q9BY66

  • Chr Location
    Yq11.223; chrY:19705415-19744939 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KDM5D associations

Human Disease Mouse Models
       Spermatogenic Failure, Y-Linked, 2; SPGFY2   OMIM: 415000
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype reference
  • All Mutations and Alleles
    1
  • Spontaneous
    1
  • Genomic Mutations
    1 involving Kdm5d
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045277 VEGA Gene Model | MGI Sequence Detail 58999 C57BL/6J ±  kb
transcript OTTMUST00000118913 VEGA | MGI Sequence Detail 7974 Not Applicable  
polypeptide OTTMUSP00000066308 VEGA | MGI Sequence Detail 1548 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    42 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
less
  • All nucleic 61
    Genomic 13
    cDNA 41
    Primer pair 6
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-16566
References
more
  • Summaries
    All 43
    Developmental Gene Expression 11
    Gene Ontology 5
    Phenotypes 1
  • Earliest
    J:18900 Agulnik AI, et al., A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens. Hum Mol Genet. 1994 Jun;3(6):873-8
  • Latest
    J:215367 Shao GB, et al., Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development. In Vitro Cell Dev Biol Anim. 2014 Aug;50(7):603-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory