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Gpd2
Gene Detail
Symbol

Name
ID
Gpd2
glycerol phosphate dehydrogenase 2, mitochondrial
MGI:99778
Synonyms
Gdm1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
31.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:57237635-57370719 bp, + strand
From VEGA annotation of GRCm38

  133085 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:352  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GPD2
Protein SuperFamily: mitochondrial glycerol-3-phosphate dehydrogenase
Gene Tree: Gpd2

Human
homologs
GPD2, glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2820
neXtProt AC: NX_P43304

Human Synonyms: GDH2, GPDM, mGPDH

Human Chr (Location): 2q24.1; chr2:156435290-156586403 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GPD2

Mutations,
alleles, and
phenotypes
All mutations/alleles(67) : Gene trapped(65) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit diminished hepatic ATP levels, decreased adiposity and fasting blood glucose, and, on an inbred background, reductions in preweaning viability and fertility.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Gpd2 interacts with 379 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process camera-type eye development, gluconeogenesis, ...
Component glycerol-3-phosphate dehydrogenase complex, membrane, ...
Function calcium ion binding, glycerol-3-phosphate dehydrogenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (114)    Tissues (96)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 114
cDNA source data(113)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gpd2 ; ZFIN gpd2    NEW 
Molecular
reagents
All nucleic(116) cDNA(115) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000012561 (Evidence)
Ensembl Gene Model ENSMUSG00000026827 (Evidence)
Entrez Gene 14571 (Evidence)
UniGene 3711
DFCI TC1574152, TC1597820, TC1725269
NIA Mouse Gene Index U042297
EC 1.1.5.3
Consensus CDS Project CCDS16045.1
International Mouse Phenotyping Consortium Status Gpd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012561 VEGA Gene Model | MGI Sequence Detail 133085 C57BL/6J ±  kb
transcript OTTMUST00000029883 VEGA | MGI Sequence Detail 5759 Not Applicable 
polypeptide OTTMUSP00000013434 VEGA | MGI Sequence Detail 745 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(649 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase
InterPro IPR006076 FAD dependent oxidoreductase
Protein Ontology PR:000008171 glycerol-3-phosphate dehydrogenase, mitochondrial
References
(Earliest) J:36995 Koza RA, et al., Sequence and tissue-dependent RNA expression of mouse FAD-linked glycerol-3-phosphate dehydrogenase. Arch Biochem Biophys. 1996 Dec 1;336(1):97-104
(Latest) J:190044 Saheki T, et al., Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency. Mol Genet Metab. 2012 Nov;107(3):322-9
All references(57)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16564, MGI:2138752, MGI:2138952, MGI:2139193, MGI:2139355

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory