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Gpd2 Gene Detail
Summary
  • Symbol
    Gpd2
  • Name
    glycerol phosphate dehydrogenase 2, mitochondrial
  • Synonyms
    Gdm1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99778
    NCBI Gene: 14571
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:57237635-57370719 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      133085 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 31.66 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    GPD2, glycerol-3-phosphate dehydrogenase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GPD2, glycerol-3-phosphate dehydrogenase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GDH2, GPDM, mGPDH
  • Links
    NCBI Gene ID: 2820
    neXtProt AC: NX_P43304
    UniProt: P43304

  • Chr Location
    2q24.1; chr2:156435290-156586403 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human GPD2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 4 genetic backgrounds
    17 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit diminished hepatic ATP levels, decreased adiposity and fasting blood glucose, and, on an inbred background, reductions in preweaning viability and fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000012561 VEGA Gene Model | MGI Sequence Detail 133085 C57BL/6J ±  kb
    transcript OTTMUST00000029883 VEGA | MGI Sequence Detail 5759 Not Applicable  
    polypeptide OTTMUSP00000013434 VEGA | MGI Sequence Detail 745 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      646 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
    • InterPro Domains
      IPR031656 Alpha-glycerophosphate oxidase, C-terminal
      IPR038299 Alpha-glycerophosphate oxidase, C-terminal domain superfamily
      IPR018247 EF-Hand 1, calcium-binding site
      IPR002048 EF-hand domain
      IPR011992 EF-hand domain pair
      IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase
      IPR006076 FAD dependent oxidoreductase
      IPR036188 FAD/NAD(P)-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 117
      cDNA 116
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-16564, MGI:2138752, MGI:2138952, MGI:2139193, MGI:2139355
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 10
      Phenotypes 22
    • Earliest
      J:33877 Matsutani A, et al., Molecular cloning of human mitochondrial glycerophosphate dehydrogenase gene: genomic structure, chromosomal localization, and existence of a pseudogene. Biochem Biophys Res Commun. 1996 Jun 25;223(3):481-6
    • Latest
      J:243313 Saheki T, et al., Oral aversion to dietary sugar, ethanol and glycerol correlates with alterations in specific hepatic metabolites in a mouse model of human citrin deficiency. Mol Genet Metab. 2017 Apr;120(4):306-316

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory