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Gpd2
Gene Detail
 Symbol
Name
ID
Gpd2
glycerol phosphate dehydrogenase 2, mitochondrial
MGI:99778
Synonyms Gdm1
Feature Type protein coding gene
Genetic Map
Chromosome 2
31.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:57237635-57370719 bp, + strand
From VEGA annotation of GRCm38

  133085 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:352  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: mitochondrial glycerol-3-phosphate dehydrogenase
Gene Tree: Gpd2

Human
homologs
Human Homolog GPD2, glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
NCBI Gene ID 2820
neXtProt AC  NX_P43304
Human Synonyms  GDH2, GPDM, mGPDH
Human Chr (Location)  2q24.1; chr2:156435453-156586403 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GPD2
Alleles
and
phenotypes
All alleles(67) : Gene trapped(65) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit diminished hepatic ATP levels, decreased adiposity and fasting blood glucose, and, on an inbred background, reductions in preweaning viability and fertility.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process camera-type eye development, gluconeogenesis, ...
Component glycerol-3-phosphate dehydrogenase complex, membrane, ...
Function calcium ion binding, glycerol-3-phosphate dehydrogenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (114)    Tissues (96)    Images (41)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 114
cDNA source data(113)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(116) cDNA(115) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000012561 (Evidence)
Ensembl Gene ModelENSMUSG00000026827 (Evidence)
Entrez Gene14571 (Evidence)
UniGene3711
DFCITC1574152, TC1597820, TC1725269
NIA Mouse Gene IndexU042297
EC1.1.5.3
Consensus CDS ProjectCCDS16045.1
International Mouse Knockout Project StatusGpd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012561 VEGA Gene Model | MGI Sequence Detail 133085 C57BL/6J ±  kb
transcript OTTMUST00000029883 VEGA | MGI Sequence Detail 5759 Not Applicable 
polypeptide OTTMUSP00000013434 VEGA | MGI Sequence Detail 745 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(4) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(649 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase
InterPro IPR006076 FAD dependent oxidoreductase
Protein Ontology PR:000008171 glycerol-3-phosphate dehydrogenase, mitochondrial
References (Earliest) J:33877 Matsutani A, et al., Molecular cloning of human mitochondrial glycerophosphate dehydrogenase gene: genomic structure, chromosomal localization, and existence of a pseudogene. Biochem Biophys Res Commun. 1996 Jun 25;223(3):481-6
(Latest) J:190044 Saheki T, et al., Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency. Mol Genet Metab. 2012 Nov;107(3):322-9
All references(59)
Other
accession IDs
MGD-MRK-16564, MGI:2138752, MGI:2138952, MGI:2139193, MGI:2139355

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory