Gpd2
Gene Detail

Symbol Name ID

Gpd2 glycerol phosphate dehydrogenase 2, mitochondrial MGI:99778

Synonyms

Gdm1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

31.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr2:57237635-57370719 bp, + strand From VEGA annotation of GRCm38   133085 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:352  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: mitochondrial glycerol-3-phosphate dehydrogenase
Gene Tree: Gpd2

Human homologs

Human Homolog		GPD2, glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
NCBI Gene ID		2820
neXtProt AC		NX_P43304
Human Synonyms		GDH2, GPDM, mGPDH
Human Chr (Location)		2q24.1; chr2:157291965-157442915 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GPD2

Alleles and phenotypes

All alleles(67) : Targeted(2) Gene trapped(65)
 

Homozygotes for targeted null mutations exhibit diminished hepatic ATP levels, decreased adiposity and fasting blood glucose, and, on an inbred background, reductions in preweaning viability and fertility.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	gluconeogenesis, glycerol-3-phosphate metabolic process, ...
Component	glycerol-3-phosphate dehydrogenase complex, membrane, ...
Function	calcium ion binding, glycerol-3-phosphate dehydrogenase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (114)    Tissues (96)    Images (41)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	114

cDNA source data(113)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(116) cDNA(115) Primer pair(1)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000012561 (Evidence)
Ensembl Gene Model	ENSMUSG00000026827 (Evidence)
Entrez Gene	14571 (Evidence)
UniGene	3711
DFCI	TC1574152, TC1597820, TC1725269
NIA Mouse Gene Index	U042297
EC	1.1.5.3
Consensus CDS Project	CCDS16045.1
International Mouse Knockout Project Status	Gpd2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012561	VEGA Gene Model | MGI Sequence Detail	133085	C57BL/6J
transcript	OTTMUST00000029883	VEGA | MGI Sequence Detail	5759	Not Applicable
polypeptide	OTTMUSP00000013434	VEGA | MGI Sequence Detail	745	Not Applicable

All sequences(56) RefSeq(4) UniProt(2)

Polymorphisms

RFLP(2) : SNPs within 2kb(649 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR002048	EF-hand domain
InterPro	IPR011992	EF-hand domain pair
InterPro	IPR000447	FAD-dependent glycerol-3-phosphate dehydrogenase
InterPro	IPR006076	FAD dependent oxidoreductase
Protein Ontology	PR:000008171	glycerol-3-phosphate dehydrogenase, mitochondrial

References

(Earliest) J:33877 Matsutani A, et al., Molecular cloning of human mitochondrial glycerophosphate dehydrogenase gene: genomic structure, chromosomal localization, and existence of a pseudogene. Biochem Biophys Res Commun. 1996 Jun 25;223(3):481-6
(Latest) J:190044 Saheki T, et al., Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency. Mol Genet Metab. 2012 Nov;107(3):322-9
All references(59)

Other accession IDs

MGD-MRK-16564, MGI:2138752, MGI:2138952, MGI:2139193, MGI:2139355