Cdc25b
Gene Detail

Symbol Name ID

Cdc25b cell division cycle 25B MGI:99701

Feature Type

protein coding gene

Genetic Map

Chromosome 2

63.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:131186949-131198497 bp, + strand From VEGA annotation of GRCm38   11549 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41451  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: protein-tyrosine-phosphatase Cdc25A
Gene Tree: Cdc25b

Human homologs

Human Homolog		CDC25B, cell division cycle 25B
NCBI Gene ID		994
neXtProt AC		NX_P30305
Human Chr (Location)		20p13; chr20:3776401-3786762 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(2)
 

The resumption of meiosis during oocyte maturation is blocked in homozygous mutant female mice, resulting in female infertility. Male mice do not show an overt reproductive phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	cell cycle, cell division, ...
Component	centrosome, cytoplasm, ...
Function	hydrolase activity, phosphoprotein phosphatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (43)    Tissues (23)    Images (9)
Theiler Stages: 17, 23, 28

Assay Type	Results
RNA in situ	29
Northern blot	8
RT-PCR	6

cDNA source data(59)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(65) Genomic(4) cDNA(60) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016040 (Evidence)
Ensembl Gene Model	ENSMUSG00000027330 (Evidence)
Entrez Gene	12531 (Evidence)
UniGene	38444
DFCI	TC1574412, TC1590426
DoTS	DT.101246656, DT.101400519, DT.101400523, DT.101400524, DT.490640
NIA Mouse Gene Index	U002490
EC	3.1.3.48
Consensus CDS Project	CCDS16758.1, CCDS50717.1
International Mouse Knockout Project Status	Cdc25b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016040	VEGA Gene Model | MGI Sequence Detail	11549	C57BL/6J
transcript	OTTMUST00000038259	VEGA | MGI Sequence Detail	3089	Not Applicable
polypeptide	OTTMUSP00000017157	VEGA | MGI Sequence Detail	576	Not Applicable

All sequences(54) RefSeq(4) UniProt(4)

Polymorphisms

RFLP(2) : SNPs(68 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000751	M-phase inducer phosphatase
InterPro	IPR001763	Rhodanese-like domain
Protein Ontology	PR:000005192	M-phase inducer phosphatase 2

References

(Earliest) J:493 Kakizuka A, et al., A mouse cdc25 homolog is differentially and developmentally expressed. Genes Dev. 1992 Apr;6(4):578-90
(Latest) J:192903 Park YH, et al., Selenoprotein W promotes cell cycle recovery from G2 arrest through the activation of CDC25B. Biochim Biophys Acta. 2012 Dec;1823(12):2217-26
All references(58)

Other accession IDs

MGD-MRK-16486, MGI:2139016