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Cdc25b
Gene Detail
Symbol

Name
ID
Cdc25b
cell division cycle 25B
MGI:99701
Feature Type
protein coding gene
Genetic Map
Chromosome 2
63.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:131186949-131198497 bp, + strand
From VEGA annotation of GRCm38

  11549 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41451  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: CDC25B
Protein SuperFamily: protein-tyrosine-phosphatase Cdc25A
Gene Tree: Cdc25b

Human
homologs
CDC25B, cell division cycle 25B
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 994
neXtProt AC: NX_P30305

Human Chr (Location): 20p13; chr20:3786772-3806121 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
The resumption of meiosis during oocyte maturation is blocked in homozygous mutant female mice, resulting in female infertility. Male mice do not show an overt reproductive phenotype.
 
Interactions
Cdc25b interacts with 169 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cell cycle, cell division, ...
Component centrosome, cytoplasm, ...
Function hydrolase activity, phosphoprotein phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (53)    Tissues (30)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 39
Northern blot 8
RT-PCR 6
cDNA source data(59)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cdc25b    NEW 
Molecular
reagents
All nucleic(65) Genomic(4) cDNA(60) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016040 (Evidence)
Ensembl Gene Model ENSMUSG00000027330 (Evidence)
Entrez Gene 12531 (Evidence)
UniGene 38444
DFCI TC1574412, TC1590426
DoTS DT.101246656, DT.101400519, DT.101400523, DT.101400524, DT.490640
NIA Mouse Gene Index U002490
EC 3.1.3.48
Consensus CDS Project CCDS16758.1, CCDS50717.1
International Mouse Phenotyping Consortium Status Cdc25b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016040 VEGA Gene Model | MGI Sequence Detail 11549 C57BL/6J ±  kb
transcript OTTMUST00000038259 VEGA | MGI Sequence Detail 3089 Not Applicable 
polypeptide OTTMUSP00000017157 VEGA | MGI Sequence Detail 576 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(5) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000751 M-phase inducer phosphatase
InterPro IPR001763 Rhodanese-like domain
Protein Ontology PR:000005192 M-phase inducer phosphatase 2
References
(Earliest) J:493 Kakizuka A, et al., A mouse cdc25 homolog is differentially and developmentally expressed. Genes Dev. 1992 Apr;6(4):578-90
(Latest) J:208115 Zander MA, et al., Snail coordinately regulates downstream pathways to control multiple aspects of Mammalian neural precursor development. J Neurosci. 2014 Apr 9;34(15):5164-75
All references(60)
Other
accession IDs
MGD-MRK-16486, MGI:2139016

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory