About   Help   FAQ
Cdc25b
Gene Detail
Symbol

Name
ID
Cdc25b
cell division cycle 25B
MGI:99701
Feature Type
protein coding gene
Genetic Map
Chromosome 2
63.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:131186949-131198497 bp, + strand
From VEGA annotation of GRCm38

  11549 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41451  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: protein-tyrosine-phosphatase Cdc25A
Gene Tree: Cdc25b

Human
homologs
Human Homolog CDC25B, cell division cycle 25B
NCBI Gene ID 994
neXtProt AC  NX_P30305
Human Chr (Location)  20p13; chr20:3786772-3806121 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
The resumption of meiosis during oocyte maturation is blocked in homozygous mutant female mice, resulting in female infertility. Male mice do not show an overt reproductive phenotype.
 
Interactions
Cdc25b interacts with 169 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cell cycle, cell division, ...
Component centrosome, cytoplasm, ...
Function hydrolase activity, phosphoprotein phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (53)    Tissues (30)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 39
Northern blot 8
RT-PCR 6
cDNA source data(59)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(65) Genomic(4) cDNA(60) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016040 (Evidence)
Ensembl Gene ModelENSMUSG00000027330 (Evidence)
Entrez Gene12531 (Evidence)
UniGene38444
DFCITC1574412, TC1590426
DoTSDT.101246656, DT.101400519, DT.101400523, DT.101400524, DT.490640
NIA Mouse Gene IndexU002490
EC3.1.3.48
Consensus CDS ProjectCCDS16758.1, CCDS50717.1
International Mouse Knockout Project StatusCdc25b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016040 VEGA Gene Model | MGI Sequence Detail 11549 C57BL/6J ±  kb
transcript OTTMUST00000038259 VEGA | MGI Sequence Detail 3089 Not Applicable 
polypeptide OTTMUSP00000017157 VEGA | MGI Sequence Detail 576 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(5) UniProt(7)
Polymorphisms
RFLP(2) : SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000751 M-phase inducer phosphatase
InterPro IPR001763 Rhodanese-like domain
Protein Ontology PR:000005192 M-phase inducer phosphatase 2
References
(Earliest) J:493 Kakizuka A, et al., A mouse cdc25 homolog is differentially and developmentally expressed. Genes Dev. 1992 Apr;6(4):578-90
(Latest) J:208115 Zander MA, et al., Snail coordinately regulates downstream pathways to control multiple aspects of Mammalian neural precursor development. J Neurosci. 2014 Apr 9;34(15):5164-75
All references(61)
Other
accession IDs
MGD-MRK-16486, MGI:2139016

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory