Cenpc1 MGI Mouse Gene Detail - MGI:99700

Symbol

Cenpc1
Name

centromere protein C1

Feature Type

protein coding gene
IDs

MGI:99700
NCBI Gene: 12617
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:86159883-86213442 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 43.56 cM, cytoband E2-E5
Mapping Data

3 experiments

SNPs within 2kb

1424 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99700	protein coding gene	Chr5:86159877-86214325 (-)
129S1/SvImJ	ENSMUSG00200008046	protein coding gene	Chr5:81882280-81937645 (-)
A/J	ENSMUSG00195024688	protein coding gene	Chr5:81060993-81114560 (-)
AKR/J	ENSMUSG00220011093	protein coding gene	Chr5:81194972-81248542 (-)
BALB/cJ	ENSMUSG00180000053	protein coding gene	Chr5:80905097-80958558 (-)
C3H/HeJ	ENSMUSG00175037222	protein coding gene	Chr5:82977797-83031249 (-)
C57BL/6NJ	ENSMUSG00215030272	protein coding gene	Chr5:81754122-81807692 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027336	protein coding gene	Chr5:79140955-79203542 (-)
CAST/EiJ	ENSTCUG00005013011	protein coding gene	Chr5:80558437-80612043 (-)
CBA/J	ENSMUSG00210004505	protein coding gene	Chr5:81796856-81850308 (-)
DBA/2J	ENSMUSG00185039332	protein coding gene	Chr5:83721173-83774629 (-)
FVB/NJ	ENSMUSG00205001116	protein coding gene	Chr5:80603565-80657161 (-)
JF1/MsJ	ENSUMUG00000000710	protein coding gene	Chr5:88109506-88162439 (-)
LP/J	ENSMUSG00230001491	protein coding gene	Chr5:88419369-88474729 (-)
NOD/ShiLtJ	ENSMUSG00190007659	protein coding gene	Chr5:80663318-80716893 (-)
NZO/HlLtJ	ENSMUSG00225008492	protein coding gene	Chr5:93444604-93498604 (-)
PWK/PhJ	ENSLUMG00010007231	protein coding gene	Chr5:80596047-80650857 (-)
SPRET/EiJ	ENSMSPG00010028402	protein coding gene	Chr5:82821560-82876651 (-)
WSB/EiJ	ENSIUOG00005027547	protein coding gene	Chr5:83616010-83669575 (-)

Human Ortholog

CENPC, centromere protein C

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CENPC, centromere protein C
Synonyms

CENP-C, CENPC1, hcp-4, MIF2
Links

HGNC:1854

NCBI Gene ID: 1060

UniProt: Q03188
Chr Location

4q13.2; chr4:67468762-67545563 (-) GRCh38

MGI Vertebrate Homology

Cenpc1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CENPC
Gene Tree

Cenpc1

Diseases

2 with human CENPC associations

				Human Disease	Mouse Models
				CREST syndrome IDs CREST syndrome DOID:0060218 ICD10CM:M34.1 MESH:D017675 NCI:C70646 UMLS_CUI:C0206138 UMLS_CUI:C1527226
				liver cirrhosis IDs liver cirrhosis DOID:5082 EFO:0001422 ICD10CM:K74.60 MESH:D008103 NCI:C2951 UMLS_CUI:C0023890

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

11
Radiation induced

1
Spontaneous

1
Targeted

1
Genomic Mutations

4 involving Cenpc1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

46 strains or lines available

Homozygous mutation of this gene results in early embryonic lethality and mitotic abnormalities.

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All GO Annotations

38
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

606
Tissues

4
cDNA Data

15
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CENPC

Xenbase cenpc

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All Sequences

59
RefSeq

20
UniProt

4
CCDS

CCDS39123.1

Ensembl

ENSMUSG00000029253 (Evidence)
NCBI Gene

12617

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029253	Ensembl Gene Model \| MGI Sequence Detail	53560	C57BL/6J	± kb
transcript	ENSMUST00000031170	Ensembl \| MGI Sequence Detail	3192	Not Applicable
polypeptide	ENSMUSP00000031170	Ensembl \| MGI Sequence Detail	906	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005325 centromere protein C

(term hierarchy)
InterPro Domains

IPR028931 CENP-C, middle DNMT3B-binding domain

IPR028386 Centromere protein C/Mif2/cnp3

IPR028052 Kinetochore assembly subunit CENP-C, N-terminal domain

IPR025974 Mif2/CENP-C cupin domain

IPR014710 PpnP-like, jelly roll fold

IPR011051 RmlC-like cupin domain superfamily

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All nucleic 24

Genomic 7

cDNA 16

Primer pair 1

Antibodies 2

Microarray probesets 3

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MGD-MRK-16485

Summaries

All 56

Developmental Gene Expression 5

Gene Ontology 12

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:381085 Kabir M, et al., A machine learning classifier to identify and prioritise genes associated with murine cardiac development. PLoS Genet. 2026 Feb;22(2):e1011489

TSS for Cenpc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr51519	Chr5:86213437-86213446 (-)	0 bp
Tssr51518	Chr5:86213390-86213433 (-)	30 bp
Tssr51517	Chr5:86213363-86213384 (-)	68 bp
Tssr51516	Chr5:86213335-86213360 (-)	94 bp
Tssr51515	Chr5:86184962-86184970 (-)	28,476 bp
Tssr51514	Chr5:86168705-86168713 (-)	44,733 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24