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Cenpc1 Gene Detail
Summary
  • Symbol
    Cenpc1
  • Name
    centromere protein C1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99700
    NCBI Gene: 12617
  • Gene Overview
    MyGene.info: CENPC
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:86012024-86065583 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 43.56 cM, cytoband E2-E5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    265 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99700
protein coding gene Chr5:86012018-86066008 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029663
protein coding gene Chr5:86830401-86891691 (-)
A/J MGP_AJ_G0029631
protein coding gene Chr5:83262183-83337052 (-)
AKR/J MGP_AKRJ_G0029579
protein coding gene Chr5:86045039-86104022 (-)
BALB/cJ MGP_BALBcJ_G0029640
protein coding gene Chr5:84186864-84244610 (-)
C3H/HeJ MGP_C3HHeJ_G0029363
protein coding gene Chr5:86529539-86595088 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030094
protein coding gene Chr5:90418175-90474504 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027336
protein coding gene Chr5:79140955-79203542 (-)
CAST/EiJ MGP_CASTEiJ_G0028771
protein coding gene Chr5:85780219-85848601 (-)
CBA/J MGP_CBAJ_G0029332
protein coding gene Chr5:93312570-93368035 (-)
DBA/2J MGP_DBA2J_G0029477
protein coding gene Chr5:83436949-83512735 (-)
FVB/NJ MGP_FVBNJ_G0029438
protein coding gene Chr5:82417137-82471080 (-)
LP/J MGP_LPJ_G0029564
protein coding gene Chr5:87237193-87300122 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029466
protein coding gene Chr5:98118367-98176716 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030127
protein coding gene Chr5:85633693-85689357 (-)
PWK/PhJ MGP_PWKPhJ_G0028495
protein coding gene Chr5:82440737-82497034 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028329
protein coding gene Chr5:84988686-85043850 (-)
WSB/EiJ MGP_WSBEiJ_G0028852
protein coding gene Chr5:85973581-86029686 (-)



Homology
more
  • Human Ortholog
    CENPC, centromere protein C
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CENPC, centromere protein C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CENP-C, CENPC1, hcp-4, MIF2
  • Links
    NCBI Gene ID: 1060
    neXtProt AC: NX_Q03188
    UniProt: Q03188

  • Chr Location
    4q13.2; chr4:67468762-67545601 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in early embryonic lethality and mitotic abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029253 Ensembl Gene Model | MGI Sequence Detail 53560 C57BL/6J ±  kb
transcript ENSMUST00000031170 Ensembl | MGI Sequence Detail 3192 Not Applicable  
polypeptide ENSMUSP00000031170 Ensembl | MGI Sequence Detail 906 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    Genomic 7
    cDNA 16

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16485
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:245683 Camlin NJ, et al., Kif4 Is Essential for Mouse Oocyte Meiosis. PLoS One. 2017;12(1):e0170650

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory