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Cenpc1 Gene Detail
Summary
  • Symbol
    Cenpc1
  • Name
    centromere protein C1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99700
    NCBI Gene: 12617
  • Gene Overview
    MyGene.info: CENPC
Location & Maps
more
  • Sequence Map
    Chr5:86012024-86065583 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      53560 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 43.56 cM, cytoband E2-E5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CENPC, centromere protein C
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CENPC, centromere protein C
    Orthology source: HomoloGene
  • Synonyms
    CENP-C, CENPC1, hcp-4, MIF2
  • Links
    NCBI Gene ID: 1060
    neXtProt AC: NX_Q03188

  • Chr Location
    4q13.2; chr4:67472271-67545538 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    2
  • Gene trapped
    12
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    4 involving Cenpc1
  • Incidental Mutations
Homozygous mutation of this gene results in early embryonic lethality and mitotic abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053352 VEGA Gene Model | MGI Sequence Detail 53560 C57BL/6J ±  kb
transcript OTTMUST00000133221 VEGA | MGI Sequence Detail 3192 Not Applicable  
polypeptide OTTMUSP00000070884 VEGA | MGI Sequence Detail 906 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    265 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000005325 centromere protein C
  • InterPro Domains
    IPR028931 CENP-C, middle DNMT3B-binding domain
    IPR028386 Centromere protein C/Mif2/cnp3
    IPR028052 Kinetochore assembly subunit CENP-C, N-terminal domain
    IPR025974 Mif2/CENP-C cupin domain
    IPR011051 RmlC-like cupin domain
    IPR014710 RmlC-like jelly roll fold
Molecular
Reagents
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  • All nucleic 22
    Genomic 7
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-16485
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:19411 McKay S, et al., Sequence homologies and linkage group conservation of the human and mouse Cenpc genes. Genomics. 1994 Jul 1;22(1):36-40
  • Latest
    J:216866 Kim J, et al., Meikin is a conserved regulator of meiosis-I-specific kinetochore function. Nature. 2014 Dec 24;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory