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Cenpc1
Gene Detail
Symbol

Name
ID
Cenpc1
centromere protein C1
MGI:99700
Feature Type
protein coding gene
Genetic Map
Chromosome 5
43.56 cM, cytoband E2-E5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:86012043-86065583 bp, - strand
From Ensembl annotation of GRCm38

  53541 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1371  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CENPC
Gene Tree: Cenpc1

Human
homologs
CENPC, centromere protein C
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1060
neXtProt AC: NX_Q03188

Human Synonyms: CENP-C, CENPC1, hcp-4, MIF2

Human Chr (Location): 4q13.2; chr4:67472271-67545538 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(12) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in early embryonic lethality and mitotic abnormalities.
 
Interactions
Cenpc1 interacts with 96 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell cycle, cell division, ...
Component chromosome, chromosome, centromeric region, ...
Function centromeric DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cenpc    NEW 
Molecular
reagents
All nucleic(22) Genomic(7) cDNA(15)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000029253 (Evidence)
Entrez Gene 12617 (Evidence)
UniGene 4649
DFCI TC1587331
DoTS DT.55127485, DT.91386646, DT.97381077
NIA Mouse Gene Index U026344
Consensus CDS Project CCDS39123.1
International Mouse Phenotyping Consortium Status Cenpc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029253 Ensembl Gene Model | MGI Sequence Detail 53541 C57BL/6J ±  kb
transcript ENSMUST00000031170 Ensembl | MGI Sequence Detail 3173 Not Applicable 
polypeptide ENSMUSP00000031170 Ensembl | MGI Sequence Detail 906 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(264 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025974 Mif2/CENP-C cupin domain
InterPro IPR011051 RmlC-like cupin domain
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000005325 centromere protein C 1
References
(Earliest) J:19411 McKay S, et al., Sequence homologies and linkage group conservation of the human and mouse Cenpc genes. Genomics. 1994 Jul 1;22(1):36-40
(Latest) J:216866 Kim J, et al., Meikin is a conserved regulator of meiosis-I-specific kinetochore function. Nature. 2014 Dec 24;
All references(34)
Other
accession IDs
MGD-MRK-16485

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory