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Cttn
Gene Detail
Symbol

Name
ID
Cttn
cortactin
MGI:99695
Synonyms
1110020L01Rik, Ems1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
88.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:144435733-144471009 bp, - strand
From VEGA annotation of GRCm38

  35277 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3834  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CTTN
Gene Tree: Cttn

Human
homologs
CTTN, cortactin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2017
neXtProt AC: NX_Q14247

Human Synonyms: EMS1

Human Chr (Location): 11q13; chr11:70398506-70436584 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(8) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for one knock-out allele exhibit abnormal early zygote development and die prior to the 2-cell stage. Mice homozygous for a different knock-out allele exhibit increased permeability in vascular and lung endothelial cells and impaired neutrophil extravasation.
 
Interactions
Cttn interacts with 130 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process actin cytoskeleton reorganization, actin filament polymerization, ...
Component actin filament, cell, ...
Function profilin binding, proline-rich region binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (103)    Tissues (62)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 88
In situ reporter (knock in) 1
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CTTN ; Xenbase cttn    NEW 
Molecular
reagents
All nucleic(23) cDNA(22) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000016455 (Evidence)
Ensembl Gene Model ENSMUSG00000031078 (Evidence)
Entrez Gene 13043 (Evidence)
DFCI TC1573932, TC1692894, TC1595599
DoTS DT.101169998, DT.101409339, DT.94375434, DT.494854, DT.110765023
NIA Mouse Gene Index U029524, U282633, U156273, U090132
PDB 2F9X, 3ULR
Consensus CDS Project CCDS22049.1, CCDS57599.1
International Mouse Phenotyping Consortium Status Cttn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016455 VEGA Gene Model | MGI Sequence Detail 35277 C57BL/6J ±  kb
transcript OTTMUST00000039645 VEGA | MGI Sequence Detail 3286 Not Applicable 
polypeptide OTTMUSP00000017695 VEGA | MGI Sequence Detail 546 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(300 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015503 Cortactin
InterPro IPR003134 Hs1/Cortactin
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000006036 src substrate cortactin
References
(Earliest) J:19932 Zhan X, et al., Murine cortactin is phosphorylated in response to fibroblast growth factor-1 on tyrosine residues late in the G1 phase of the BALB/c 3T3 cell cycle. J Biol Chem. 1993 Nov 15;268(32):24427-31
(Latest) J:208121 Lysko DE, et al., SDF1 Reduces Interneuron Leading Process Branching through Dual Regulation of Actin and Microtubules. J Neurosci. 2014 Apr 2;34(14):4941-62
All references(94)
Other
accession IDs
MGD-MRK-16480, MGI:1915873

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory