About   Help   FAQ
Cttn
Gene Detail
 Symbol
Name
ID
Cttn
cortactin
MGI:99695
Synonyms 1110020L01Rik, Ems1
Feature Type protein coding gene
Genetic Map
Chromosome 7
88.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:144435733-144471009 bp, - strand
From VEGA annotation of GRCm38

  35277 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3834  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cttn

Human
homologs
Human Homolog CTTN, cortactin
NCBI Gene ID 2017
neXtProt AC  NX_Q14247
Human Synonyms  EMS1
Human Chr (Location)  11q13; chr11:70398506-70436584 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(8) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one knock-out allele exhibit abnormal early zygote development and die prior to the 2-cell stage. Mice homozygous for a different knock-out allele exhibit increased permeability in vascular and lung endothelial cells and impaired neutrophil extravasation.
 
Interactions
Cttn interacts with 130 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process actin filament polymerization, dendritic spine maintenance, ...
Component cell cortex, cell projection, ...
Function proline-rich region binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (103)    Tissues (62)    Images (14)
Theiler Stages: 1, 15, 17, 21, 23, 27, 28
Assay TypeResults
Immunohistochemistry 14
RNA in situ 88
In situ reporter (knock in) 1
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(22) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000016455 (Evidence)
Ensembl Gene ModelENSMUSG00000031078 (Evidence)
Entrez Gene13043 (Evidence)
DFCITC1573932, TC1595599, TC1692894
DoTSDT.101169998, DT.101409339, DT.110765023, DT.494854, DT.94375434
NIA Mouse Gene IndexU029524, U090132, U156273, U282633
PDB2F9X, 3ULR
Consensus CDS ProjectCCDS22049.1, CCDS57599.1
International Mouse Knockout Project StatusCttn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016455 VEGA Gene Model | MGI Sequence Detail 35277 C57BL/6J ±  kb
transcript OTTMUST00000039645 VEGA | MGI Sequence Detail 3286 Not Applicable 
polypeptide OTTMUSP00000017695 VEGA | MGI Sequence Detail 546 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(13) UniProt(3)
Polymorphisms SNPs within 2kb(300 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015503 Cortactin
InterPro IPR003134 Hs1/Cortactin
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000006036 src substrate cortactin
References (Earliest) J:19932 Zhan X, et al., Murine cortactin is phosphorylated in response to fibroblast growth factor-1 on tyrosine residues late in the G1 phase of the BALB/c 3T3 cell cycle. J Biol Chem. 1993 Nov 15;268(32):24427-31
(Latest) J:206753 Biosse Duplan M, et al., Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and Src. Mol Cell Biol. 2014 Jan;34(1):16-29
All references(91)
Other
accession IDs
MGD-MRK-16480, MGI:1915873

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory