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Ptk6
Gene Detail
Symbol

Name
ID
Ptk6
PTK6 protein tyrosine kinase 6
MGI:99683
Synonyms
Sik, Tksk
Feature Type
protein coding gene
Genetic Map
Chromosome 2
103.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:181193721-181202789 bp, - strand
From VEGA annotation of GRCm38

  9069 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68494  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PTK6
Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree: Ptk6

Human
homologs
PTK6, protein tyrosine kinase 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5753
neXtProt AC: NX_Q13882

Human Synonyms: BRK

Human Chr (Location): 20q13.3; chr20:63528413-63537370 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display increased villus length in the jejunum and ileum and increased villus epithelial cell proliferation.
 
Interactions
Ptk6 interacts with 260 markers (Mir1b, Mir7-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process actin cytoskeleton organization, cell migration, ...
Component cell projection, cytoplasm, ...
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (42)    Tissues (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
Northern blot 24
RNase protection 11
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN ptk6a    NEW 
Molecular
reagents
All nucleic(18) Genomic(2) cDNA(15) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016561 (Evidence)
Ensembl Gene Model ENSMUSG00000038751 (Evidence)
Entrez Gene 20459 (Evidence)
UniGene 4497
DFCI TC1589354, TC1648260
DoTS DT.40161198
NIA Mouse Gene Index U023778
EC 2.7.10.2
Consensus CDS Project CCDS17203.1
International Mouse Phenotyping Consortium Status Ptk6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016561 VEGA Gene Model | MGI Sequence Detail 9069 C57BL/6J ±  kb
transcript OTTMUST00000040037 VEGA | MGI Sequence Detail 3689 Not Applicable 
polypeptide OTTMUSP00000017865 VEGA | MGI Sequence Detail 451 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 SH3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000013434 protein-tyrosine kinase 6
References
(Earliest) J:18875 Siyanova EY, et al., Tyrosine kinase gene expression in the mouse small intestine. Oncogene. 1994 Jul;9(7):2053-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)
Other
accession IDs
MGD-MRK-16468, MGD-MRK-37439, MGI:108397

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory