Tmbim6 Gene Detail

Summary

• Symbol
  Tmbim6
• Name
  transmembrane BAX inhibitor motif containing 6
• Synonyms
  Bax inhibitor 1, Tegt

• Feature Type
  protein coding gene
• IDs
  MGI:99682
  NCBI Gene: 110213
• Gene Overview
  MyGene.info: TMBIM6
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr15:99392882-99410049 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    17168 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 56.13 cM, cytoband F3
• Mapping Data
  4 experiments

Homology

• Human Ortholog
  TMBIM6, transmembrane BAX inhibitor motif containing 6

• Vertebrate Orthologs
  9

• Human Ortholog
  TMBIM6, transmembrane BAX inhibitor motif containing 6
  Orthology source: HomoloGene, HGNC
• Synonyms
  BAXI1, BI-1, TEGT
• Links
  HGNC:11723

  NCBI Gene ID: 7009

  neXtProt AC: NX_P55061

  UniProt: P55061

  
  
• Chr Location
  12q13.12; chr12:49741510-49764934 (+)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 2419
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: TMBIM6
• Protein SuperFamily
  Bax inhibitor 1
• Gene Tree
  Tmbim6
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 1 allele in 1 genetic background
  30 phenotype references
  

• All Mutations and Alleles
  27
• Chemically induced (other)
  1
• Gene trapped
  21
• Radiation induced
  2
• Targeted
  3
• Genomic Mutations
  3 involving Tmbim6
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  16 strains or lines available

Homozygous mutants display increased sensitivity to ischemic brain injury and ER stress-inducing xenobiotics.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  33
• GO References
  8

• External Resources
  FuncBase

Expression

• Assay Results
  1
• Tissues
  1
• cDNA Data
  1389
• Literature Summary
  3

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase tmbim6

Interactions

• Tmbim6 interacts with 205 markers (Mir7-1, Mir10a, Mir18, ...) View All

Sequences &
Gene Models

• All Sequences
  74
• RefSeq
  8
• UniProt
  4
• CCDS
  CCDS37201.1
• UniGene
  16769

• VEGA
  OTTMUSG00000034310 (Evidence)
• Ensembl
  ENSMUSG00000023010 (Evidence)
• NCBI Gene
  110213

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000034310	VEGA Gene Model | MGI Sequence Detail	17168	C57BL/6J
transcript	OTTMUST00000087288	VEGA | MGI Sequence Detail	2452	Not Applicable
polypeptide	OTTMUSP00000047360	VEGA | MGI Sequence Detail	237	Not Applicable

Polymorphisms

• SNPs within 2kb
  208 from dbSNP Build 142

• RFLP
  1

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000016391 Bax inhibitor 1
  (term hierarchy)
• InterPro Domains
  IPR006213 Bax inhibitor 1, conserved site
  IPR006214 Bax inhibitor 1-related

Molecular
Reagents

• All nucleic 1391

  cDNA 1390

  Primer pair 1

  
  

  Microarray probesets 2

Other
Accession IDs

MGD-MRK-16467, MGI:1915559

References

• Summaries
  All 67

  Developmental Gene Expression 3

  Diseases 1

  Gene Ontology 8

  Phenotypes 30
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:258642 Lisak D, et al., BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival. Cell Death Differ. 2016 Feb;23(2):358-68