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Tmbim6 Gene Detail
Summary
  • Symbol
    Tmbim6
  • Name
    transmembrane BAX inhibitor motif containing 6
  • Synonyms
    Bax inhibitor 1, Tegt
  • Feature Type
    protein coding gene
  • IDs
    MGI:99682
    NCBI Gene: 110213
  • Gene Overview
    MyGene.info: TMBIM6
Location & Maps
more
  • Sequence Map
    Chr15:99392882-99410049 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      17168 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.13 cM, cytoband F3
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TMBIM6, transmembrane BAX inhibitor motif containing 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TMBIM6, transmembrane BAX inhibitor motif containing 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BAXI1, BI-1, TEGT
  • Links
    NCBI Gene ID: 7009
    neXtProt AC: NX_P55061

  • Chr Location
    12q13.12; chr12:49741510-49764934 (+)  GRCh38.p2
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    1
  • Gene trapped
    21
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Tmbim6
  • Incidental Mutations
    Mutagenetix , APF
Homozygous mutants display increased sensitivity to ischemic brain injury and ER stress-inducing xenobiotics.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    32
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
    1
  • Tissues
    1
  • cDNA Data
    1389
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034310 VEGA Gene Model | MGI Sequence Detail 17168 C57BL/6J ±  kb
transcript OTTMUST00000087288 VEGA | MGI Sequence Detail 2452 Not Applicable  
polypeptide OTTMUSP00000047360 VEGA | MGI Sequence Detail 237 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    208 from dbSNP Build 142
  • RFLP
    1
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016391 Bax inhibitor 1
  • InterPro Domains
    IPR006213 Bax inhibitor 1, conserved site
    IPR006214 Bax inhibitor 1-related
Molecular
Reagents
less
  • All nucleic 1391
    cDNA 1390
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-16467, MGI:1915559
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 7
    Phenotypes 30
  • Earliest
    J:19919 Walter L, et al., A novel, conserved gene of the rat that is developmentally regulated in the testis. Mamm Genome. 1994 Apr;5(4):216-21
  • Latest
    J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory