Tmbim6 MGI Mouse Gene Detail - MGI:99682 - transmembrane BAX inhibitor motif containing 6

Symbol

Tmbim6
Name

transmembrane BAX inhibitor motif containing 6
Synonyms

Bax inhibitor 1, Tegt

Feature Type

protein coding gene
IDs

MGI:99682
NCBI Gene: 110213
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr15:99290828-99307930 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.13 cM, cytoband F3
Mapping Data

4 experiments

SNPs within 2kb

192 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99682	protein coding gene	Chr15:99290763-99307930 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022330	protein coding gene	Chr15:101235402-101252511 (+)
A/J	MGP_AJ_G0022288	protein coding gene	Chr15:97202616-97219775 (+)
AKR/J	MGP_AKRJ_G0022264	protein coding gene	Chr15:100199687-100216815 (+)
BALB/cJ	MGP_BALBcJ_G0022294	protein coding gene	Chr15:97392072-97409190 (+)
C3H/HeJ	MGP_C3HHeJ_G0022062	protein coding gene	Chr15:100259071-100277136 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022739	protein coding gene	Chr15:105003311-105023299 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020265	protein coding gene	Chr15:93096243-93113817 (+)
CAST/EiJ	MGP_CASTEiJ_G0021586	protein coding gene	Chr15:101120839-101137839 (+)
CBA/J	MGP_CBAJ_G0022031	protein coding gene	Chr15:108564377-108587207 (+)
DBA/2J	MGP_DBA2J_G0022158	protein coding gene	Chr15:96642136-96659264 (+)
FVB/NJ	MGP_FVBNJ_G0022138	protein coding gene	Chr15:95632258-95649455 (+)
LP/J	MGP_LPJ_G0022229	protein coding gene	Chr15:101375626-101395073 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022158	protein coding gene	Chr15:112497983-112515063 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022754	protein coding gene	Chr15:100291382-100309867 (+)
PWK/PhJ	MGP_PWKPhJ_G0021325	protein coding gene	Chr15:96776574-96793822 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021160	protein coding gene	Chr15:100145875-100162850 (+)
WSB/EiJ	MGP_WSBEiJ_G0021637	protein coding gene	Chr15:100825066-100842202 (+)

Human Ortholog

TMBIM6, transmembrane BAX inhibitor motif containing 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMBIM6, transmembrane BAX inhibitor motif containing 6
Synonyms

BAXI1, BI-1, TEGT
Links

HGNC:11723

NCBI Gene ID: 7009

neXtProt AC: NX_P55061

UniProt: P55061
Chr Location

12q13.12; chr12:49741510-49764934 (+) GRCh38.p7

Alliance of Genome Resources

Tmbim6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMBIM6
Gene Tree

Tmbim6

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (other)

1
Gene trapped

20
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Tmbim6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available

Homozygous mutants display increased sensitivity to ischemic brain injury and ER stress-inducing xenobiotics.

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All GO Annotations

42
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

675
Tissues

2
cDNA Data

1390
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmbim6

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Tmbim6 interacts with 205 markers (Mir7-1, Mir10a, Mir18, ...) View All

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All Sequences

83
RefSeq

10
UniProt

6
CCDS

CCDS37201.1

Ensembl

ENSMUSG00000023010 (Evidence)
NCBI Gene

110213

			Length	Strain/Species	Flank
genomic	110213	NCBI Gene Model \| MGI Sequence Detail	17103	C57BL/6J	± kb
transcript	NM_001171034	RefSeq \| MGI Sequence Detail	2612	C57BL/6
polypeptide	Q9D2C7	UniProt \| EBI \| MGI Sequence Detail	237	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000016391 Bax inhibitor 1

(term hierarchy)
InterPro Domains

IPR006213 Bax inhibitor 1, conserved site

IPR006214 Bax inhibitor 1-related

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All nucleic 1394

cDNA 1391

Primer pair 2

Other 1

Microarray probesets 2

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MGD-MRK-16467, MGI:1915559

Summaries

All 74

Developmental Gene Expression 4

Diseases 1

Gene Ontology 9

Phenotypes 35
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:313279 Kim HK, et al., TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium. Autophagy. 2021 Mar;17(3):761-778

TSS for Tmbim6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133011	Chr15:99290770-99290784 (+)	-51 bp
Tssr133012	Chr15:99290829-99290868 (+)	21 bp
Tssr133013	Chr15:99291113-99291129 (+)	293 bp
Tssr133014	Chr15:99291136-99291160 (+)	320 bp
Tssr133015	Chr15:99291455-99291480 (+)	640 bp
Tssr133016	Chr15:99291481-99291488 (+)	657 bp
Tssr133017	Chr15:99291492-99291518 (+)	677 bp
Tssr133018	Chr15:99291832-99291869 (+)	1,023 bp
Tssr133019	Chr15:99295759-99295764 (+)	4,934 bp
Tssr133020	Chr15:99297650-99297684 (+)	6,839 bp
Tssr133021	Chr15:99299692-99299707 (+)	8,872 bp
Tssr133022	Chr15:99300002-99300024 (+)	9,185 bp
Tssr133023	Chr15:99302290-99302315 (+)	11,475 bp
Tssr133024	Chr15:99303730-99303758 (+)	12,916 bp
Tssr133025	Chr15:99303779-99303810 (+)	12,967 bp
Tssr133026	Chr15:99304027-99304038 (+)	13,205 bp
Tssr133027	Chr15:99304072-99304081 (+)	13,249 bp
Tssr133028	Chr15:99304449-99304512 (+)	13,653 bp
Tssr133029	Chr15:99306409-99306434 (+)	15,594 bp
Tssr133030	Chr15:99306580-99306595 (+)	15,760 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/28/2022 MGI 6.20