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Actn3
Gene Detail
 Symbol
Name
ID
Actn3
actinin alpha 3
MGI:99678
Feature Type protein coding gene
Genetic Map
Chromosome 19
4.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:4861223-4877909 bp, - strand
From VEGA annotation of GRCm38

  16687 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:862  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: alpha-actinin
Gene Tree: Actn3

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(16) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit an increase mitochondria density and a shift from anaerobic to aerobic metabolism in fast muscle fiber that is associated with increased aerobic capacity.
 
Interactions
Actn3 interacts with 27 markers (Mir34a, Mir34b, Mir34c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process muscle contraction
Component sarcomere, striated muscle thin filament, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (65)    Tissues (12)    Images (23)
Theiler Stages: 17, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 40
RT-PCR 24
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(27) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016351 (Evidence)
Ensembl Gene ModelENSMUSG00000006457 (Evidence)
Entrez Gene11474 (Evidence)
UniGene5316
DFCITC1581775
DoTSDT.50314921
NIA Mouse Gene IndexU019074
Consensus CDS ProjectCCDS29441.1
International Mouse Knockout Project StatusActn3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016351 VEGA Gene Model | MGI Sequence Detail 16687 C57BL/6J ±  kb
transcript OTTMUST00000039318 VEGA | MGI Sequence Detail 2880 Not Applicable 
polypeptide OTTMUSP00000017571 VEGA | MGI Sequence Detail 900 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(97 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001589 Actinin-type, actin-binding, conserved site
InterPro IPR001715 Calponin homology domain
InterPro IPR014837 EF-hand, Ca insensitive
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR018159 Spectrin/alpha-actinin
InterPro IPR002017 Spectrin repeat
Protein Ontology PR:000003690 alpha-actinin-3
References (Earliest) J:32589 Schiaffino S, et al., Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev. 1996 Apr;76(2):371-423
(Latest) J:207120 Garton FC, et al., alpha-Actinin-3 deficiency alters muscle adaptation in response to denervation and immobilization. Hum Mol Genet. 2014 Apr 1;23(7):1879-93
All references(58)
Other
accession IDs
MGD-MRK-16463

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory