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Adcy1 Gene Detail
Summary
  • Symbol
    Adcy1
  • Name
    adenylate cyclase 1
  • Synonyms
    AC1, D11Bwg1392e, I-AC
  • Feature Type
    protein coding gene
  • IDs
    MGI:99677
    NCBI Gene: 432530
  • Gene Overview
    MyGene.info: ADCY1
Location & Maps
more
  • Sequence Map
    Chr11:7063489-7178506 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      115018 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 4.72 cM, cytoband A2
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    ADCY1, adenylate cyclase 1 (brain)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADCY1, adenylate cyclase 1 (brain)
    Orthology source: HomoloGene
  • Synonyms
    AC1, DFNB44
  • Links
    NCBI Gene ID: 107
    neXtProt AC: NX_Q08828

  • Chr Location
    7p12.3; chr7:45574140-45723116 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ADCY1 associations

Human Disease Mouse Models
       Deafness, Autosomal Recessive 44; DFNB44   OMIM: 610154
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 4 alleles in 8 genetic backgrounds
    5 phenotypes from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    6
  • Incidental Mutations
Mice homozygous for an insertional or null mutation fail to develop normal patterned distribution of neurons in the brain and display behavioral and learning abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005134 VEGA Gene Model | MGI Sequence Detail 115018 C57BL/6J ±  kb
transcript OTTMUST00000011485 VEGA | MGI Sequence Detail 12259 Not Applicable  
polypeptide OTTMUSP00000005342 VEGA | MGI Sequence Detail 1118 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    698 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 22
    Genomic 5
    cDNA 13
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-16462, MGD-MRK-33713, MGD-MRK-34052, MGI:106029, MGI:106360
References
more
  • Summaries
    All 99
    Developmental Gene Expression 8
    Gene Ontology 10
    Phenotypes 65
  • Earliest
    J:22287 Wu ZL, et al., Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice. Proc Natl Acad Sci U S A. 1995 Jan 3;92(1):220-4
  • Latest
    J:219338 Koga K, et al., Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain. Neuron. 2015 Jan 21;85(2):377-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory