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Adcy1
Gene Detail
 Symbol
Name
ID
Adcy1
adenylate cyclase 1
MGI:99677
Synonyms AC1, D11Bwg1392e, I-AC
Feature Type protein coding gene
Genetic Map
Chromosome 11
4.72 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:7063489-7178506 bp, + strand
From VEGA annotation of GRCm38

  115018 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41419  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: adenylate cyclase
Gene Tree: Adcy1

Human
homologs
Human Homolog ADCY1, adenylate cyclase 1 (brain)
NCBI Gene ID 107
neXtProt AC  NX_Q08828
Human Synonyms  AC1, DFNB44
Human Chr (Location)  7p13-p12; chr7:45574140-45723116 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ADCY1
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Spontaneous(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an insertional or null mutation fail to develop normal patterned distribution of neurons in the brain and display behavioral and learning abnormalities.
 
Interactions
Adcy1 interacts with 558 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process activation of adenylate cyclase activity, axonogenesis, ...
Component extracellular vesicular exosome, integral component of membrane, ...
Function adenylate cyclase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (672)    Tissues (233)    Images (77)
Theiler Stages: 21, 22, 23, 26, 28
Assay TypeResults
RNA in situ 672
cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(5) cDNA(13) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000005134 (Evidence)
Ensembl Gene ModelENSMUSG00000020431 (Evidence)
Entrez Gene432530 (Evidence)
DoTSDT.110505523, DT.40137336, DT.87031912
EC4.6.1.1
Consensus CDS ProjectCCDS24426.1
International Mouse Knockout Project StatusAdcy1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005134 VEGA Gene Model | MGI Sequence Detail 115018 C57BL/6J ±  kb
transcript OTTMUST00000011485 VEGA | MGI Sequence Detail 12259 Not Applicable 
polypeptide OTTMUSP00000005342 VEGA | MGI Sequence Detail 1118 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(701 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
Protein Ontology PR:000003751 adenylate cyclase type 1
References (Earliest) J:22287 Wu ZL, et al., Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice. Proc Natl Acad Sci U S A. 1995 Jan 3;92(1):220-4
(Latest) J:202325 Hwang CK, et al., Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells. J Neurosci. 2013 Sep 18;33(38):14989-97
All references(96)
Other
accession IDs
MGD-MRK-16462, MGD-MRK-33713, MGD-MRK-34052, MGI:106029, MGI:106360

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory