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Adcy1
Gene Detail
Symbol

Name
ID
Adcy1
adenylate cyclase 1
MGI:99677
Synonyms
AC1, D11Bwg1392e, I-AC
Feature Type
protein coding gene
Genetic Map
Chromosome 11
4.72 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:7063489-7178506 bp, + strand
From VEGA annotation of GRCm38

  115018 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41419  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADCY1
Protein SuperFamily: adenylate cyclase
Gene Tree: Adcy1

Human
homologs
ADCY1, adenylate cyclase 1 (brain)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 107
neXtProt AC: NX_Q08828

Human Synonyms: AC1, DFNB44

Human Chr (Location): 7p12.3; chr7:45574140-45723116 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ADCY1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Spontaneous(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for an insertional or null mutation fail to develop normal patterned distribution of neurons in the brain and display behavioral and learning abnormalities.
 
Interactions
Adcy1 interacts with 557 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process activation of adenylate cyclase activity, axonogenesis, ...
Component cytoplasm, extracellular exosome, ...
Function adenylate cyclase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (672)    Tissues (233)    Images (77)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 672
cDNA source data(11)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase adcy1 ; ZFIN adcy1a, adcy1b    NEW 
Molecular
reagents
All nucleic(22) Genomic(5) cDNA(13) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000005134 (Evidence)
Ensembl Gene Model ENSMUSG00000020431 (Evidence)
Entrez Gene 432530 (Evidence)
DoTS DT.110505523, DT.40137336, DT.87031912
EC 4.6.1.1
Consensus CDS Project CCDS24426.1
International Mouse Phenotyping Consortium Status Adcy1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005134 VEGA Gene Model | MGI Sequence Detail 115018 C57BL/6J ±  kb
transcript OTTMUST00000011485 VEGA | MGI Sequence Detail 12259 Not Applicable 
polypeptide OTTMUSP00000005342 VEGA | MGI Sequence Detail 1118 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(701 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
Protein Ontology PR:000003751 adenylate cyclase type 1
References
(Earliest) J:22287 Wu ZL, et al., Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice. Proc Natl Acad Sci U S A. 1995 Jan 3;92(1):220-4
(Latest) J:219338 Koga K, et al., Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain. Neuron. 2015 Jan 21;85(2):377-89
All references(99)
Other
accession IDs
MGD-MRK-16462, MGD-MRK-33713, MGD-MRK-34052, MGI:106029, MGI:106360

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory