About   Help   FAQ
Adcy4
Gene Detail
Symbol

Name
ID
Adcy4
adenylate cyclase 4
MGI:99674
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:55769058-55784042 bp, - strand
From Ensembl annotation of GRCm38

  14985 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23149  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: ADCY4
Protein SuperFamily: adenylate cyclase
Gene Tree: Adcy4

Human
homologs
ADCY4, adenylate cyclase 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 196883
neXtProt AC: NX_Q8NFM4

Human Synonyms: AC4

Human Chr (Location): 14q12; chr14:24318349-24335071 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions of this gene display a normal phenotype.
 
Interactions
Adcy4 interacts with 10 markers (Mir137, Mir192, Mir325, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (328)    Tissues (232)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 204
In situ reporter (knock in) 40
RT-PCR 84
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase adcy4    NEW 
Molecular
reagents
All nucleic(22) cDNA(18) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000022220 (Evidence)
Entrez Gene 104110 (Evidence)
UniGene 287010
DFCI TC1585404, TC1722101
DoTS DT.101273065, DT.522114, DT.99856045
NIA Mouse Gene Index U035590
EC 4.6.1.1
Consensus CDS Project CCDS27130.1
International Mouse Phenotyping Consortium Status Adcy4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022220 Ensembl Gene Model | MGI Sequence Detail 14985 C57BL/6J ±  kb
transcript ENSMUST00000170223 Ensembl | MGI Sequence Detail 3500 Not Applicable 
polypeptide ENSMUSP00000130530 Ensembl | MGI Sequence Detail 1077 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(10) UniProt(4)
Polymorphisms
SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009398 Adenylate cyclase-like
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
Protein Ontology PR:000003755 adenylate cyclase type 4
References
(Earliest) J:46601 Gao BN, et al., Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10178-82
(Latest) J:208831 Kittikulsuth W, et al., Adenylyl cyclase 4 does not regulate collecting duct water and sodium handling. Physiol Rep. 2014;2(3):e00277
All references(36)
Other
accession IDs
MGD-MRK-16459

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory