Adcy4
Gene Detail

Symbol Name ID

Adcy4 adenylate cyclase 4 MGI:99674

Feature Type

protein coding gene

Genetic Map

Chromosome 14

28.19 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr14:55769092-55784019 bp, - strand From NCBI annotation of GRCm38   14928 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Adcy4 ± 2 cM)

Gene Tree: Adcy4

Human ortholog

ADCY4 adenylate cyclase 4 NCBI Gene ID 196883
Human Synonyms: AC4
Human Chr14:24787570-24803864 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions of this gene display a normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	activation of adenylate cyclase activity, adenylate cyclase-modulating G-protein coupled receptor signaling pathway, ...
Component	cytoplasm, dendrite, ...
Function	adenylate cyclase activity, ATP binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (279)    Tissues (183)    Images (29)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	155
In situ reporter (knock in)	40
RT-PCR	84

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(18) Primer pair(2) Other(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000022220 (Evidence)
Entrez Gene	104110 (Evidence)
UniGene	287010
DFCI	TC1585404, TC1722101
DoTS	DT.101273065, DT.522114, DT.99856045
NIA Mouse Gene Index	U035590
EC	4.6.1.1
Consensus CDS Project	CCDS27130.1
International Mouse Knockout Project Status	Adcy4

Sequences

Length	Strain/Species
genomic	104110	NCBI Gene Model | MGI Sequence Detail	14928	C57BL/6J
transcript	NM_080435	RefSeq | MGI Sequence Detail	3414	FVB/N
polypeptide	Q91WF3	UniProt | EBI | MGI Sequence Detail	1077	Not Applicable

All sequences(25) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(61 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009398	Adenylate cyclase-like
InterPro	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro	IPR018297	Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
Protein Ontology	PR:000003755	adenylate cyclase type 4

Graphical View of Protein Domain Structure

References

(Earliest) J:46601 Gao BN, et al., Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10178-82
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)

Other accession IDs

MGD-MRK-16459