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Adcy4
Gene Detail
 Symbol
Name
ID
Adcy4
adenylate cyclase 4
MGI:99674
Feature Type protein coding gene
Genetic Map
Chromosome 14
28.19 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:55769092-55784019 bp, - strand
From NCBI annotation of GRCm38

  14928 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23149  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: adenylate cyclase
Gene Tree: Adcy4

Human
homologs
Human Homolog ADCY4, adenylate cyclase 4
NCBI Gene ID 196883
neXtProt AC  NX_Q8NFM4
Human Synonyms  AC4
Human Chr (Location)  14q12; chr14:24318349-24335071 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene display a normal phenotype.
 
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process activation of adenylate cyclase activity, adenylate cyclase-modulating G-protein coupled receptor signaling pathway, ...
Component cytoplasm, dendrite, ...
Function adenylate cyclase activity, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (328)    Tissues (232)    Images (31)
Theiler Stages: 22, 23, 26, 28
Assay TypeResults
RNA in situ 204
In situ reporter (knock in) 40
RT-PCR 84
cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(22) cDNA(18) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000022220 (Evidence)
Entrez Gene104110 (Evidence)
UniGene287010
DFCITC1585404, TC1722101
DoTSDT.101273065, DT.522114, DT.99856045
NIA Mouse Gene IndexU035590
EC4.6.1.1
Consensus CDS ProjectCCDS27130.1
International Mouse Knockout Project StatusAdcy4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 104110 NCBI Gene Model | MGI Sequence Detail 14928 C57BL/6J ±  kb
transcript NM_080435 RefSeq | MGI Sequence Detail 3414 FVB/N 
polypeptide Q91WF3 UniProt | EBI | MGI Sequence Detail 1077 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(10) UniProt(4)
Polymorphisms SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009398 Adenylate cyclase-like
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
Protein Ontology PR:000003755 adenylate cyclase type 4
Graphical View of Protein Domain Structure
References (Earliest) J:46601 Gao BN, et al., Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10178-82
(Latest) J:201159 Zhou P, et al., Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15395-400
All references(37)
Other
accession IDs
MGD-MRK-16459

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory