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Siglec1
Gene Detail
Symbol

Name
ID
Siglec1
sialic acid binding Ig-like lectin 1, sialoadhesin
MGI:99668
Synonyms
CD169, Siglec-1, Sn
Feature Type
protein coding gene
Genetic Map
Chromosome 2
63.26 cM, cytoband F-H1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:131069220-131086765 bp, - strand
From VEGA annotation of GRCm38

  17546 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:124458  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: SIGLEC1
Protein SuperFamily: sialoadhesin
Gene Tree: Siglec1

Human
homologs
SIGLEC1, sialic acid binding Ig-like lectin 1, sialoadhesin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6614
neXtProt AC: NX_Q9BZZ2

Human Synonyms: CD169, dJ1009E24.1, SIGLEC-1, SN

Human Chr (Location): 20p13; chr20:3686970-3712617 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a disruption in this gene display subtle changes in B- and T-cell populations and decreased IgM levels. Mice homozygous for a knock-out or knock-in allele exhibit impaired phagocytosis of sialylated C. jejuni.
 
Interactions
Siglec1 interacts with 148 markers (Mir7-1, Mir7-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell adhesion, endocytosis, ...
Component extracellular region, integral component of membrane, ...
Function carbohydrate binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase siglec1    NEW 
Molecular
reagents
All nucleic(39) Genomic(10) cDNA(28) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000015684 (Evidence)
Ensembl Gene Model ENSMUSG00000027322 (Evidence)
Entrez Gene 20612 (Evidence)
UniGene 1374
DFCI TC1590530, TC1616785, TC1695767
DoTS DT.40184685, DT.94269669, DT.94269671
NIA Mouse Gene Index U023375
PDB 1OD7, 1OD9, 1ODA, 1QFO, 1QFP, 1URL, 2BVE
Consensus CDS Project CCDS16754.2
International Mouse Phenotyping Consortium Status Siglec1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015684 VEGA Gene Model | MGI Sequence Detail 17546 C57BL/6J ±  kb
transcript OTTMUST00000037285 VEGA | MGI Sequence Detail 6387 Not Applicable 
polypeptide OTTMUSP00000016700 VEGA | MGI Sequence Detail 1701 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(8) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR013106 Immunoglobulin V-set domain
Protein Ontology PR:000001931 sialoadhesin
References
(Earliest) J:20831 Crocker PR, et al., Sialoadhesin, a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin-like domains. EMBO J. 1994 Oct 3;13(19):4490-503
(Latest) J:218229 Gaya M, et al., Host response. Inflammation-induced disruption of SCS macrophages impairs B cell responses to secondary infection. Science. 2015 Feb 6;347(6222):667-72
All references(53)
Other
accession IDs
MGD-MRK-16453

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory