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Siglec1 Gene Detail
Summary
  • Symbol
    Siglec1
  • Name
    sialic acid binding Ig-like lectin 1, sialoadhesin
  • Synonyms
    CD169, Siglec-1, Sn
  • Feature Type
    protein coding gene
  • IDs
    MGI:99668
    NCBI Gene: 20612
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:131069220-131086765 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17546 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 63.26 cM, cytoband F-H1
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    SIGLEC1, sialic acid binding Ig like lectin 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SIGLEC1, sialic acid binding Ig like lectin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD169, dJ1009E24.1, SIGLEC-1, SN
  • Links
    NCBI Gene ID: 6614
    neXtProt AC: NX_Q9BZZ2
    UniProt: Q9BZZ2

  • Chr Location
    20p13; chr20:3686970-3712558 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display subtle changes in B- and T-cell populations and decreased IgM levels. Mice homozygous for a knock-out or knock-in allele exhibit impaired phagocytosis of sialylated C. jejuni.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000015684 VEGA Gene Model | MGI Sequence Detail 17546 C57BL/6J ±  kb
    transcript OTTMUST00000037285 VEGA | MGI Sequence Detail 6387 Not Applicable  
    polypeptide OTTMUSP00000016700 VEGA | MGI Sequence Detail 1701 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      127 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 10
      cDNA 28
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16453
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 40
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:260090 Gaya M, et al., Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells. Cell. 2018 Jan 25;172(3):517-533.e20

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory