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Pola1 Gene Detail
Summary
  • Symbol
    Pola1
  • Name
    polymerase (DNA directed), alpha 1
  • Synonyms
    Pola
  • Feature Type
    protein coding gene
  • IDs
    MGI:99660
    NCBI Gene: 18968
Location & Maps
more
  • Sequence Map
    ChrX:93304767-93632155 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      327389 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 41.06 cM, cytoband C-D
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    POLA1, polymerase (DNA) alpha 1, catalytic subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    POLA1, polymerase (DNA) alpha 1, catalytic subunit
    Orthology source: HomoloGene
  • Synonyms
    NSX, p180, POLA
  • Links
    NCBI Gene ID: 5422
    neXtProt AC: NX_P09884

  • Chr Location
    Xp22.1-p21.3; chrX:24693874-24996986 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human POLA1 associations

Human Disease Mouse Models
       N Syndrome; NSX   OMIM: 310465
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 images
    7 phenotype references
Male chimeras hemizygous for a gene trapped allele appear normal at E10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017971 VEGA Gene Model | MGI Sequence Detail 327389 C57BL/6J ±  kb
transcript OTTMUST00000043405 VEGA | MGI Sequence Detail 5346 Not Applicable  
polypeptide OTTMUSP00000019499 VEGA | MGI Sequence Detail 1465 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    983 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012960 DNA polymerase alpha catalytic subunit
  • EC
  • InterPro Domains
    IPR006172 DNA-directed DNA polymerase, family B
    IPR017964 DNA-directed DNA polymerase, family B, conserved site
    IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
    IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
    IPR029702 DNA polymerase alpha catalytic subunit
    IPR024647 DNA polymerase alpha catalytic subunit, N-terminal domain
    IPR023211 DNA polymerase, palm domain
    IPR012337 Ribonuclease H-like domain
    IPR015088 Zinc finger, DNA-directed DNA polymerase, family B, alpha
Molecular
Reagents
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  • All nucleic 62
    Genomic 1
    cDNA 60
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-13577, MGD-MRK-16445, MGI:2148008
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 7
  • Earliest
    J:11191 Adler DA, et al., Physical mapping of the genes for three components of the mouse DNA replication complex: polymerase alpha to the X chromosome, primase p49 subunit to chromosome 10, and primase p58 subunit to chromosome 1. Genomics. 1991 Apr;9(4):642-6
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory