About   Help   FAQ
Pola1
Gene Detail
 Symbol
Name
ID
Pola1
polymerase (DNA directed), alpha 1
MGI:99660
Synonyms Pola
Feature Type protein coding gene
Genetic Map
Chromosome X
41.06 cM, cytoband C-D
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
ChrX:93304767-93632155 bp, - strand
From VEGA annotation of GRCm38

  327389 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6802  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA polymerase
Gene Tree: Pola1

Human
homologs
Human Homolog POLA1, polymerase (DNA directed), alpha 1, catalytic subunit
NCBI Gene ID 5422
neXtProt AC  NX_P09884
Human Synonyms  NSX, p180, POLA
Human Chr (Location)  Xp22.1-p21.3; chrX:24693921-24996986 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human POLA1
Alleles
and
phenotypes
All alleles(23) : Gene trapped(22) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Male chimeras hemizygous for a gene trapped allele appear normal at E10.5.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process cell proliferation, DNA biosynthetic process, ...
Component alpha DNA polymerase:primase complex, chromatin, ...
Function 3'-5' exonuclease activity, 4 iron, 4 sulfur cluster binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(60)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(62) Genomic(1) cDNA(60) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017971 (Evidence)
Ensembl Gene ModelENSMUSG00000006678 (Evidence)
Entrez Gene18968 (Evidence)
UniGene1923
DFCITC1580826, TC1774959
DoTSDT.530465, DT.91381138, DT.94173094
NIA Mouse Gene IndexU039530
EC2.7.7.7
Consensus CDS ProjectCCDS30272.1
International Mouse Knockout Project StatusPola1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017971 VEGA Gene Model | MGI Sequence Detail 327389 C57BL/6J ±  kb
transcript OTTMUST00000043405 VEGA | MGI Sequence Detail 5346 Not Applicable 
polypeptide OTTMUSP00000019499 VEGA | MGI Sequence Detail 1465 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(12) UniProt(3)
Polymorphisms SNPs within 2kb(1024 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006172 DNA-directed DNA polymerase, family B
InterPro IPR017964 DNA-directed DNA polymerase, family B, conserved site
InterPro IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
InterPro IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
InterPro IPR004578 DNA-directed DNA polymerase, family B, pol2
InterPro IPR024647 DNA polymerase alpha catalytic subunit, N-terminal domain
InterPro IPR023211 DNA polymerase, palm domain
InterPro IPR012337 Ribonuclease H-like domain
InterPro IPR015088 Zinc finger, DNA-directed DNA polymerase, family B, alpha
Protein Ontology PR:000012960 DNA polymerase alpha catalytic subunit
References (Earliest) J:11191 Adler DA, et al., Physical mapping of the genes for three components of the mouse DNA replication complex: polymerase alpha to the X chromosome, primase p49 subunit to chromosome 10, and primase p58 subunit to chromosome 1. Genomics. 1991 Apr;9(4):642-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(46)
Other
accession IDs
MGD-MRK-13577, MGD-MRK-16445, MGI:2148008

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory