Pola1
Gene Detail

Symbol Name ID

Pola1 polymerase (DNA directed), alpha 1 MGI:99660

Synonyms

Pola

Feature Type

protein coding gene

Genetic Map

Chromosome X

41.06 cM, cytoband C-D
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

ChrX:93304767-93632155 bp, - strand From VEGA annotation of GRCm38   327389 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:6802  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA polymerase
Gene Tree: Pola1

Human homologs

Human Homolog		POLA1, polymerase (DNA directed), alpha 1, catalytic subunit
NCBI Gene ID		5422
neXtProt AC		NX_P09884
Human Synonyms		p180, POLA
Human Chr (Location)		Xp22.1-p21.3; chrX:24712064-25015103 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human POLA1

Alleles and phenotypes

All alleles(23) : Targeted(1) Gene trapped(22)
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (47 annotations)

Process	cell proliferation, DNA replication, ...
Component	alpha DNA polymerase:primase complex, chromatin, ...
Function	3'-5' exonuclease activity, 4 iron, 4 sulfur cluster binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(62)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(64) Genomic(1) cDNA(62) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000017971 (Evidence)
Ensembl Gene Model	ENSMUSG00000006678 (Evidence)
Entrez Gene	18968 (Evidence)
UniGene	1923
DFCI	TC1580826, TC1774959
DoTS	DT.530465, DT.91381138, DT.94173094
NIA Mouse Gene Index	U039530
EC	2.7.7.7
Consensus CDS Project	CCDS30272.1
International Mouse Knockout Project Status	Pola1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017971	VEGA Gene Model | MGI Sequence Detail	327389	C57BL/6J
transcript	OTTMUST00000043405	VEGA | MGI Sequence Detail	5346	Not Applicable
polypeptide	OTTMUSP00000019499	VEGA | MGI Sequence Detail	1465	Not Applicable

All sequences(34) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(1026 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006172	DNA-directed DNA polymerase, family B
InterPro	IPR017964	DNA-directed DNA polymerase, family B, conserved site
InterPro	IPR006133	DNA-directed DNA polymerase, family B, exonuclease domain
InterPro	IPR006134	DNA-directed DNA polymerase, family B, multifunctional domain
InterPro	IPR004578	DNA-directed DNA polymerase, family B, pol2
InterPro	IPR024647	DNA polymerase alpha catalytic subunit, N-terminal domain
InterPro	IPR023211	DNA polymerase, palm domain
InterPro	IPR012337	Ribonuclease H-like domain
InterPro	IPR015088	Zinc finger, DNA-directed DNA polymerase, family B, alpha
Protein Ontology	PR:000012960	DNA polymerase alpha catalytic subunit

References

(Earliest) J:11191 Adler DA, et al., Physical mapping of the genes for three components of the mouse DNA replication complex: polymerase alpha to the X chromosome, primase p49 subunit to chromosome 10, and primase p58 subunit to chromosome 1. Genomics. 1991 Apr;9(4):642-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(46)

Other accession IDs

MGD-MRK-13577, MGD-MRK-16445, MGI:2148008