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Mark2
Gene Detail
Symbol

Name
ID
Mark2
MAP/microtubule affinity-regulating kinase 2
MGI:99638
Synonyms
Emk, Par-1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
5.32 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr19:7275396-7341860 bp, - strand
From VEGA annotation of GRCm38

  66465 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69013  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Mark2

Human
homologs
Human Homolog MARK2, MAP/microtubule affinity-regulating kinase 2
NCBI Gene ID 2011
neXtProt AC  NX_Q7KZI7
Human Synonyms  EMK1, EMK-1, PAR-1, Par1b, Par-1b
Human Chr (Location)  11q13.1; chr11:63838928-63911020 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(135) : Gene trapped(132) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit proportionate dwarfism with smaller pituitaries and reduced growth hormone and prolactin secretion. Mutants develop autoimmunity and fail to breed when mated to each other.
 
Interactions
Mark2 interacts with 298 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cell differentiation, establishment of cell polarity, ...
Component actin filament, basal cortex, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (1)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 1
cDNA source data(124)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(124) cDNA(124)
Microarray probesets(7)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035747 VEGA Gene Model | MGI Sequence Detail 66465 C57BL/6J ±  kb
transcript OTTMUST00000091403 VEGA | MGI Sequence Detail 2660 Not Applicable 
polypeptide OTTMUSP00000050351 VEGA | MGI Sequence Detail 776 Not Applicable 

For the selected sequences
All sequences(216) RefSeq(40) UniProt(37)
Polymorphisms
RFLP(1) : SNPs within 2kb(199 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001772 Kinase associated domain 1 (KA1)
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
Protein Ontology PR:000010187 serine/threonine-protein kinase MARK2
References
(Earliest) J:12907 Inglis JD, et al., Emk, a protein kinase with homologs in yeast maps to mouse chromosome 19. Mamm Genome. 1993;4(7):401-3
(Latest) J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39
All references(59)
Other
accession IDs
MGD-MRK-16423, MGI:2147655

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory