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Kcnb2
Gene Detail
Symbol

Name
ID
Kcnb2
potassium voltage gated channel, Shab-related subfamily, member 2
MGI:99632
Synonyms
9630047L19Rik, Kv2.2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
4.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:15287254-15723750 bp, + strand
From VEGA annotation of GRCm38

  436497 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31263  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KCNB2
Protein SuperFamily: potassium voltage-gated channel, subfamily B
Gene Tree: Kcnb2

Human
homologs
KCNB2, potassium channel, voltage gated Shab related subfamily B, member 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9312
neXtProt AC: NX_Q92953

Human Synonyms: KV2.2

Human Chr (Location): 8q13.2; chr8:72537391-72938349 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation exhibit neurological abnormalities when compared with controls, including an abnormal sleep/wake cycle, decreased exploratory and locomotor activity, and a motor strength deficit.
 
Interactions
Kcnb2 interacts with 465 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component dendrite, integral component of membrane, ...
Function delayed rectifier potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (53)    Tissues (30)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 45
RT-PCR 8
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase kcnb2    NEW 
Molecular
reagents
All nucleic(9) cDNA(6) Primer pair(1) Other(2)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000042215 (Evidence)
Ensembl Gene Model ENSMUSG00000092083 (Evidence)
Entrez Gene 98741 (Evidence)
UniGene 156081
DFCI TC1613173, TC1615032
DoTS DT.91326863
NIA Mouse Gene Index U000065
Consensus CDS Project CCDS48222.1
International Mouse Phenotyping Consortium Status Kcnb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042215 VEGA Gene Model | MGI Sequence Detail 436497 C57BL/6J ±  kb
transcript OTTMUST00000125547 VEGA | MGI Sequence Detail 3963 Not Applicable 
polypeptide OTTMUSP00000068035 VEGA | MGI Sequence Detail 907 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(9) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(3642 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3658)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR005821 Ion transport domain
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003973 Potassium channel, voltage dependent, Kv2
InterPro IPR005826 Potassium channel, voltage dependent, Kv2.2
InterPro IPR003091 Voltage-dependent potassium channel
Protein Ontology PR:000000723 voltage-gated potassium channel KCNB2
References
(Earliest) J:10462 Wei A, et al., K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse. Science. 1990 May 4;248(4955):599-603
(Latest) J:198672 Tong H, et al., Protection from noise-induced hearing loss by Kv2.2 potassium currents in the central medial olivocochlear system. J Neurosci. 2013 May 22;33(21):9113-21
All references(32)
Other
accession IDs
MGD-MRK-16417, MGI:2138636

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory