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Kcnb2
Gene Detail
Symbol

Name
ID
Kcnb2
potassium voltage gated channel, Shab-related subfamily, member 2
MGI:99632
Synonyms
9630047L19Rik, Kv2.2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
4.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:15287254-15723750 bp, + strand
From VEGA annotation of GRCm38

  436497 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31263  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, subfamily B

Human
homologs
Human Homolog KCNB2, potassium voltage-gated channel, Shab-related subfamily, member 2
NCBI Gene ID 9312
neXtProt AC  NX_Q92953
Human Synonyms  KV2.2
Human Chr (Location)  8q13.2; chr8:72537391-72938581 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation exhibit neurological abnormalities when compared with controls, including an abnormal sleep/wake cycle, decreased exploratory and locomotor activity, and a motor strength deficit.
 
Interactions
Kcnb2 interacts with 466 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component integral component of membrane, membrane, ...
Function delayed rectifier potassium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (53)    Tissues (30)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 45
RT-PCR 8
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(6) Primer pair(1) Other(2)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000042215 (Evidence)
Ensembl Gene ModelENSMUSG00000090498 (Evidence), ENSMUSG00000092083 (Evidence)
Entrez Gene98741 (Evidence)
UniGene156081
DFCITC1613173, TC1615032
DoTSDT.91326863
NIA Mouse Gene IndexU000065
Consensus CDS ProjectCCDS48222.1
International Mouse Knockout Project StatusKcnb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042215 VEGA Gene Model | MGI Sequence Detail 436497 C57BL/6J ±  kb
transcript OTTMUST00000125547 VEGA | MGI Sequence Detail 3963 Not Applicable 
polypeptide OTTMUSP00000068035 VEGA | MGI Sequence Detail 907 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(9) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(3642 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3658)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR005821 Ion transport domain
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
InterPro IPR003968 Potassium channel, voltage dependent, Kv
InterPro IPR003973 Potassium channel, voltage dependent, Kv2
InterPro IPR005826 Potassium channel, voltage dependent, Kv2.2
InterPro IPR003091 Voltage-dependent potassium channel
Protein Ontology PR:000000723 voltage-gated potassium channel KCNB2
References
(Earliest) J:10462 Wei A, et al., K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse. Science. 1990 May 4;248(4955):599-603
(Latest) J:198672 Tong H, et al., Protection from noise-induced hearing loss by Kv2.2 potassium currents in the central medial olivocochlear system. J Neurosci. 2013 May 22;33(21):9113-21
All references(33)
Other
accession IDs
MGD-MRK-16417, MGI:2138636

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory