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Mst1r Gene Detail
Summary
  • Symbol
    Mst1r
  • Name
    macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
  • Synonyms
    CDw136, friend virus susceptibility 2, Fv2, Fv-2, PTK8, Ron, STK
  • Feature Type
    protein coding gene
  • IDs
    MGI:99614
    NCBI Gene: 19882
  • Gene Overview
    MyGene.info: MST1R
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107906873-107920383 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.07 cM, cytoband F1
  • Mapping Data
    31 experiments
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99614
protein coding gene Chr9:107906858-107920383 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035272
protein coding gene Chr9:109820518-109834033 (+)
A/J MGP_AJ_G0035251
protein coding gene Chr9:105811006-105824523 (+)
AKR/J MGP_AKRJ_G0035183
protein coding gene Chr9:108451807-108465320 (+)
BALB/cJ MGP_BALBcJ_G0035245
protein coding gene Chr9:105480934-105494452 (+)
C3H/HeJ MGP_C3HHeJ_G0034955
protein coding gene Chr9:108849677-108863192 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035765
protein coding gene Chr9:112790556-112804062 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032663
protein coding gene Chr9:103243553-103257031 (+)
CAST/EiJ MGP_CASTEiJ_G0034266
protein coding gene Chr9:108804930-108818442 (+)
CBA/J MGP_CBAJ_G0034923
protein coding gene Chr9:116779482-116796242 (+)
DBA/2J MGP_DBA2J_G0035084
protein coding gene Chr9:105265220-105278799 (+)
FVB/NJ MGP_FVBNJ_G0035032
protein coding gene Chr9:104031085-104044603 (+)
LP/J MGP_LPJ_G0035160
protein coding gene Chr9:110017214-110030721 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035071
protein coding gene Chr9:118384116-118397631 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035786
protein coding gene Chr9:108727462-108740981 (+)
PWK/PhJ MGP_PWKPhJ_G0033973
protein coding gene Chr9:105586756-105600369 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033808
protein coding gene Chr9:108791761-108805279 (+)
WSB/EiJ MGP_WSBEiJ_G0034387
protein coding gene Chr9:108608368-108621885 (+)



Homology
more
  • Human Ortholog
    MST1R, macrophage stimulating 1 receptor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MST1R, macrophage stimulating 1 receptor
    Orthology source: HomoloGene
  • Synonyms
    CD136, CDw136, NPCA3, PTK8, RON
  • Links
    NCBI Gene ID: 4486
    neXtProt AC: NX_Q04912
    UniProt: Q04912

  • Chr Location
    3p21.31; chr3:49886471-49903637 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MST1R associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 6 alleles in 10 genetic backgrounds
    3 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
This locus controls susceptibility to splenomegaly or spleen focus formation induced by inoculation with Friend leukemia virus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032584 Ensembl Gene Model | MGI Sequence Detail 13511 C57BL/6J ±  kb
    transcript ENSMUST00000035203 Ensembl | MGI Sequence Detail 4722 Not Applicable  
    polypeptide ENSMUSP00000035203 Ensembl | MGI Sequence Detail 1378 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 3
      cDNA 18
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16399, MGD-MRK-9896, MGD-MRK-9902, MGI:95596
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 32
    • Earliest
      J:172785 Friend C, Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia. J Exp Med. 1957 Apr 1;105(4):307-18
    • Latest
      J:221258 Privette Vinnedge LM, et al., The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers. Oncogene. 2015 Apr 30;34(18):2325-36

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory