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Mst1r Gene Detail
Summary
  • Symbol
    Mst1r
  • Name
    macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
  • Synonyms
    CDw136, friend virus susceptibility 2, Fv2, Fv-2, PTK8, Ron, STK
  • Feature Type
    protein coding gene
  • IDs
    MGI:99614
    NCBI Gene: 19882
  • Gene Overview
    MyGene.info: MST1R
Location & Maps
more
  • Sequence Map
    Chr9:107906873-107920383 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13511 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MST1R, macrophage stimulating 1 receptor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MST1R, macrophage stimulating 1 receptor
    Orthology source: HomoloGene
  • Synonyms
    CD136, CDw136, PTK8, RON
  • Links
    NCBI Gene ID: 4486
    neXtProt AC: NX_Q04912

  • Chr Location
    3p21.3; chr3:49886981-49903873 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 6 alleles in 10 genetic backgrounds
    3 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Spontaneous
    1
  • Targeted
    8
  • Transgenic
    2
  • Incidental Mutations
This locus controls susceptibility to splenomegaly or spleen focus formation induced by inoculation with Friend leukemia virus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050789 VEGA Gene Model | MGI Sequence Detail 13511 C57BL/6J ±  kb
transcript OTTMUST00000128721 VEGA | MGI Sequence Detail 4722 Not Applicable  
polypeptide OTTMUSP00000069228 VEGA | MGI Sequence Detail 1378 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    68 from dbSNP Build 142
  • PCR
Protein
Information
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Molecular
Reagents
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  • All nucleic 20
    Genomic 3
    cDNA 16
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-16399, MGD-MRK-9896, MGD-MRK-9902, MGI:95596
References
more
  • Summaries
    All 99
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 32
  • Earliest
    J:172785 Friend C, Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia. J Exp Med. 1957 Apr 1;105(4):307-18
  • Latest
    J:221747 Kulkarni RM, et al., Ron receptor signaling is protective against DSS-induced colitis in mice. Am J Physiol Gastrointest Liver Physiol. 2014 Jun 15;306(12):G1065-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory