Ephb2
Gene Detail

Symbol Name ID

Ephb2 Eph receptor B2 MGI:99611

Synonyms

Cek5, Drt, Erk, eteck, Hek5, Nuk, Prkm5, Qek5, Sek3, Tyro5

Feature Type

protein coding gene

Genetic Map

Chromosome 4

69.00 cM, cytoband D-E
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr4:136647539-136835988 bp, - strand From VEGA annotation of GRCm38   188450 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37925  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Ephb2

Human homologs

Human Homolog		EPHB2, EPH receptor B2
NCBI Gene ID		2048
neXtProt AC		NX_P29323
Human Synonyms		CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5
Human Chr (Location)		1p36.1-p35; chr1:23037331-23241823 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human EPHB2

Alleles and phenotypes

All alleles(47) : Targeted(6) Gene trapped(41)
 

Mice homozygous for a null allele exhibit abnormal axon guidance, circling, head bobbing, and hyperactivity.

 

Gene Ontology (GO) classifications

All GO classifications: (68 annotations)

Process	angiogenesis, axonal fasciculation, ...
Component	axon, cell projection, ...
Function	ATP binding, axon guidance receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (89 records)
Data Summary: Results (325)    Tissues (230)    Images (78)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	314
Western blot	3
RT-PCR	8

cDNA source data(83)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(93) Genomic(2) cDNA(86) Primer pair(3) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000009767 (Evidence)
Ensembl Gene Model	ENSMUSG00000028664 (Evidence)
Entrez Gene	13844 (Evidence)
UniGene	250981
DFCI	TC1583075, TC1631069, TC1652827
DoTS	DT.101375254, DT.91326728, DT.94236638, DT.99696502
NIA Mouse Gene Index	U025671, U186913
EC	2.7.10.1
PDB	1JPA, 1KGY, 1NUK, 1SHW, 2HEN, 3ETP
Consensus CDS Project	CCDS18809.1
International Mouse Knockout Project Status	Ephb2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009767	VEGA Gene Model | MGI Sequence Detail	188450	C57BL/6J
transcript	OTTMUST00000022612	VEGA | MGI Sequence Detail	4804	Not Applicable
polypeptide	OTTMUSP00000010324	VEGA | MGI Sequence Detail	987	Not Applicable

All sequences(49) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(1096 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001090	Ephrin receptor ligand binding domain
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR008979	Galactose-binding domain-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR009030	Insulin-like growth factor binding protein, N-terminal
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR001660	Sterile alpha motif domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR021129	Sterile alpha motif, type 1
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016257	Tyrosine-protein kinase, ephrin receptor
InterPro	IPR011641	Tyrosine-protein kinase ephrin type A/B receptor-like
InterPro	IPR001426	Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology	PR:000007130	ephrin type-B receptor 2

References

(Earliest) J:31545 Ben-David Y, et al., A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators. EMBO J. 1991 Feb;10(2):317-25
(Latest) J:195711 Shi F, et al., The expression of Pax6 variants is subject to posttranscriptional regulation in the developing mouse eyelid. PLoS One. 2013;8(1):e53919
All references(173)

Other accession IDs

MGD-MRK-16396, MGD-MRK-35869, MGD-MRK-36579, MGD-MRK-39556, MGI:109557