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Ephb2
Gene Detail
Symbol

Name
ID
Ephb2
Eph receptor B2
MGI:99611
Synonyms
Cek5, Drt, Erk, eteck, Hek5, Nuk, Prkm5, Qek5, Sek3, Tyro5
Feature Type
protein coding gene
Genetic Map
Chromosome 4
69.00 cM, cytoband D-E
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr4:136647539-136835988 bp, - strand
From VEGA annotation of GRCm38

  188450 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37925  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: EPHB2
Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Ephb2

Human
homologs
EPHB2, EPH receptor B2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2048
neXtProt AC: NX_P29323

Human Synonyms: CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5

Human Chr (Location): 1p36.1-p35; chr1:22710770-22915330 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human EPHB2

Mutations,
alleles, and
phenotypes
All mutations/alleles(49) : Gene trapped(41) Targeted(8)
Genomic Mutations involving Ephb2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit abnormal axon guidance, circling, head bobbing, and hyperactivity.
 
Interactions
Ephb2 interacts with 480 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (70 annotations)
Process angiogenesis, axonal fasciculation, ...
Component axon, cell projection, ...
Function ATP binding, axon guidance receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (104 records)
Data Summary: Results (353)    Tissues (246)    Images (90)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 327
In situ reporter (knock in) 11
Western blot 3
RT-PCR 8
cDNA source data(80)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA EPHB2 ZFIN ephb2a    NEW 
Molecular
reagents
All nucleic(92) Genomic(2) cDNA(83) Primer pair(3) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000009767 (Evidence)
Ensembl Gene Model ENSMUSG00000028664 (Evidence)
Entrez Gene 13844 (Evidence)
UniGene 250981
DFCI TC1631069, TC1583075, TC1652827
DoTS DT.99696502, DT.94236638, DT.91326728, DT.101375254
NIA Mouse Gene Index U186913, U025671
EC 2.7.10.1
PDB 2HEN, 1SHW, 1NUK, 1KGY, 1JPA, 3ETP
Consensus CDS Project CCDS18809.1, CCDS71498.1
International Mouse Phenotyping Consortium Status Ephb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009767 VEGA Gene Model | MGI Sequence Detail 188450 C57BL/6J ±  kb
transcript OTTMUST00000022613 VEGA | MGI Sequence Detail 3653 Not Applicable 
polypeptide OTTMUSP00000010325 VEGA | MGI Sequence Detail 987 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(12) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(2130 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001090 Ephrin receptor ligand binding domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR021129 Sterile alpha motif, type 1
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016257 Tyrosine-protein kinase, ephrin receptor
InterPro IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
InterPro IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology PR:000007130 ephrin type-B receptor 2
References
(Earliest) J:31545 Ben-David Y, et al., A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators. EMBO J. 1991 Feb;10(2):317-25
(Latest) J:221209 Vaiyapuri S, et al., EphB2 regulates contact-dependent and contact-independent signaling to control platelet function. Blood. 2015 Jan 22;125(4):720-30
All references(196)
Other
accession IDs
MGD-MRK-16396, MGD-MRK-35869, MGD-MRK-36579, MGD-MRK-39556, MGI:109557

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory