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Ephb2
Gene Detail
 Symbol
Name
ID
Ephb2
Eph receptor B2
MGI:99611
Synonyms Cek5, Drt, Erk, eteck, Hek5, Nuk, Prkm5, Qek5, Sek3, Tyro5
Feature Type protein coding gene
Genetic Map
Chromosome 4
69.00 cM, cytoband D-E
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr4:136647539-136835988 bp, - strand
From VEGA annotation of GRCm38

  188450 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37925  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Ephb2

Human
homologs
Human Homolog EPHB2, EPH receptor B2
NCBI Gene ID 2048
neXtProt AC  NX_P29323
Human Synonyms  CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5
Human Chr (Location)  1p36.1-p35; chr1:22710770-22915330 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human EPHB2
Alleles
and
phenotypes
All alleles(48) : Gene trapped(41) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit abnormal axon guidance, circling, head bobbing, and hyperactivity.
 
Gene Ontology
(GO)
classifications
All GO classifications: (70 annotations)
Process angiogenesis, axonal fasciculation, ...
Component axon, cell projection, ...
Function ATP binding, axon guidance receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (93 records)
Data Summary: Results (336)    Tissues (236)    Images (83)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 321
Western blot 3
RT-PCR 8
cDNA source data(79)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(91) Genomic(2) cDNA(82) Primer pair(3) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000009767 (Evidence)
Ensembl Gene ModelENSMUSG00000028664 (Evidence)
Entrez Gene13844 (Evidence)
UniGene250981
DFCITC1583075, TC1631069, TC1652827
DoTSDT.101375254, DT.91326728, DT.94236638, DT.99696502
NIA Mouse Gene IndexU025671, U186913
EC2.7.10.1
PDB1JPA, 1KGY, 1NUK, 1SHW, 2HEN, 3ETP
Consensus CDS ProjectCCDS18809.1, CCDS71498.1
International Mouse Knockout Project StatusEphb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009767 VEGA Gene Model | MGI Sequence Detail 188450 C57BL/6J ±  kb
transcript OTTMUST00000022612 VEGA | MGI Sequence Detail 4804 Not Applicable 
polypeptide OTTMUSP00000010324 VEGA | MGI Sequence Detail 987 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(12) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(2130 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001090 Ephrin receptor ligand binding domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR021129 Sterile alpha motif, type 1
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016257 Tyrosine-protein kinase, ephrin receptor
InterPro IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
InterPro IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology PR:000007130 ephrin type-B receptor 2
References (Earliest) J:31545 Ben-David Y, et al., A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators. EMBO J. 1991 Feb;10(2):317-25
(Latest) J:203654 Srivastava N, et al., EphB2 receptor forward signaling controls cortical growth cone collapse via Nck and Pak. Mol Cell Neurosci. 2013 Jan;52:106-16
All references(182)
Other
accession IDs
MGD-MRK-16396, MGD-MRK-35869, MGD-MRK-36579, MGD-MRK-39556, MGI:109557

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory