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Ephb2 Gene Detail
Summary
  • Symbol
    Ephb2
  • Name
    Eph receptor B2
  • Synonyms
    Cek5, Drt, Erk, eteck, Hek5, Nuk, Prkm5, Qek5, Sek3, Tyro5
  • Feature Type
    protein coding gene
  • IDs
    MGI:99611
    NCBI Gene: 13844
  • Gene Overview
    MyGene.info: EPHB2
Location & Maps
more
  • Sequence Map
    Chr4:136647539-136835988 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      188450 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 69.00 cM, cytoband D-E
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    EPHB2, EPH receptor B2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    EPHB2, EPH receptor B2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5
  • Links
    NCBI Gene ID: 2048
    neXtProt AC: NX_P29323

  • Chr Location
    1p36.12; chr1:22710770-22915330 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human EPHB2 associations

Human Disease Mouse Models
       Prostate Cancer/Brain Cancer Susceptibility   OMIM: 603688
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 4 alleles in 5 genetic backgrounds
    30 phenotypes from multigenic genotypes
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    51
  • Chemically induced (other)
    2
  • Gene trapped
    41
  • Targeted
    8
  • Genomic Mutations
    3 involving Ephb2
  • Incidental Mutations
Mice homozygous for a null allele exhibit abnormal axon guidance, circling, head bobbing, and hyperactivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009767 VEGA Gene Model | MGI Sequence Detail 188450 C57BL/6J ±  kb
transcript OTTMUST00000022612 VEGA | MGI Sequence Detail 4804 Not Applicable  
polypeptide OTTMUSP00000010324 VEGA | MGI Sequence Detail 987 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2113 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 92
    Genomic 2
    cDNA 83
    Primer pair 3
    Other 4

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-16396, MGD-MRK-35869, MGD-MRK-36579, MGD-MRK-39556, MGI:109557
References
more
  • Summaries
    All 209
    Developmental Gene Expression 114
    Gene Ontology 21
    Phenotypes 63
  • Earliest
    J:31545 Ben-David Y, et al., A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators. EMBO J. 1991 Feb;10(2):317-25
  • Latest
    J:235677 Noraz N, et al., Syk kinases are required for spinal commissural axon repulsion at the midline via the ephrin/Eph pathway. Development. 2016 Jun 15;143(12):2183-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory