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Abca2
Gene Detail
Symbol

Name
ID
Abca2
ATP-binding cassette, sub-family A (ABC1), member 2
MGI:99606
Synonyms
Abc2, D2H0S1474E, mKIAA1062
Feature Type
protein coding gene
Genetic Map
Chromosome 2
17.25 cM, cytoband A2-B
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr2:25428703-25448540 bp, + strand
From VEGA annotation of GRCm38

  19838 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55590  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ABCA2
Gene Tree: Abca2

Human
homologs
ABCA2, ATP-binding cassette, sub-family A (ABC1), member 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 20
neXtProt AC: NX_Q9BZC7

Human Synonyms: ABC2

Human Chr (Location): 9q34; chr9:137007234-137028974 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Null mice show tremors, hyperactivity, abnormal coordination, and alterations in CNS myelin sheath ultrastructure,
 
Interactions
Abca2 interacts with 204 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (109)    Tissues (102)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 109
cDNA source data(112)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase abca2    NEW 
Molecular
reagents
All nucleic(115) cDNA(114) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000012108 (Evidence)
Ensembl Gene Model ENSMUSG00000026944 (Evidence)
Entrez Gene 11305 (Evidence)
UniGene 2210
DFCI TC1708381
DoTS DT.488925
NIA Mouse Gene Index U001493
Consensus CDS Project CCDS15773.1
International Mouse Phenotyping Consortium Status Abca2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012108 VEGA Gene Model | MGI Sequence Detail 19838 C57BL/6J ±  kb
transcript OTTMUST00000028850 VEGA | MGI Sequence Detail 8033 Not Applicable 
polypeptide OTTMUSP00000013051 VEGA | MGI Sequence Detail 2433 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(18) UniProt(5)
Polymorphisms
RFLP(3) : SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR026082 ABC transporter A, ABCA
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000003540 ATP-binding cassette sub-family A member 2
References
(Earliest) J:24443 Higgins CF, ABC transporters: from microorganisms to man. Annu Rev Cell Biol. 1992;8:67-113
(Latest) J:210038 Davis W Jr, The ATP-binding cassette transporter-2 (ABCA2) regulates esterification of plasma membrane cholesterol by modulation of sphingolipid metabolism. Biochim Biophys Acta. 2014 Jan;1841(1):168-79
All references(46)
Other
accession IDs
MGD-MRK-16391, MGD-MRK-5803, MGI:2138926

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory