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Cntfr
Gene Detail
 Symbol
Name
ID
Cntfr
ciliary neurotrophic factor receptor
MGI:99605
Synonyms Cntfralpha
Feature Type protein coding gene
Genetic Map
Chromosome 4
21.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr4:41657498-41697089 bp, - strand
From VEGA annotation of GRCm38

  39592 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9619  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ciliary neurotrophic factor receptor-like protein
Gene Tree: Cntfr

Human
homologs
Human Homolog CNTFR, ciliary neurotrophic factor receptor
NCBI Gene ID 1271
neXtProt AC  NX_P26992
Human Chr (Location)  9p13; chr9:34551427-34590714 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(33) Targeted(6)
Incidental mutations (data from Mutagenetix )
 
Homozygous mutant animals exhibit a significant reduction in the number of motor neurons. Neonatal mutants fail to suckle and die within 24 hours after birth.
 
Interactions
Cntfr interacts with 211 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process brainstem development, ciliary neurotrophic factor-mediated signaling pathway, ...
Component anchored component of membrane, CNTFR-CLCF1 complex, ...
Function ciliary neurotrophic factor receptor activity, cytokine binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (87)    Tissues (87)    Images (16)
Theiler Stages: 10, 18, 19, 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 66
RT-PCR 21
cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(3) cDNA(20) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006676 (Evidence)
Ensembl Gene ModelENSMUSG00000028444 (Evidence)
Entrez Gene12804 (Evidence)
UniGene425178
DFCITC1584718, TC1594688
DoTSDT.101365949, DT.40137927, DT.55171368
NIA Mouse Gene IndexU024975
Consensus CDS ProjectCCDS18067.1, CCDS51142.1
International Mouse Knockout Project StatusCntfr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006676 VEGA Gene Model | MGI Sequence Detail 39592 C57BL/6J ±  kb
transcript OTTMUST00000015290 VEGA | MGI Sequence Detail 1995 Not Applicable 
polypeptide OTTMUSP00000007063 VEGA | MGI Sequence Detail 372 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(15) UniProt(5)
Polymorphisms RFLP(3) : SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013151 Immunoglobulin
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR003530 Long hematopoietin receptor, soluble alpha chain, conserved site
Protein Ontology PR:000005664 ciliary neurotrophic factor receptor subunit alpha
References (Earliest) J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
(Latest) J:202165 Lee N, et al., The contribution of ciliary neurotrophic factor receptors to adult motor neuron survival in vivo is specific to insult type and distinct from that for embryonic motor neurons. J Comp Neurol. 2013 Oct 1;521(14):3217-25
All references(62)
Other
accession IDs
MGD-MRK-16390

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory