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Cntfr
Gene Detail
Symbol

Name
ID
Cntfr
ciliary neurotrophic factor receptor
MGI:99605
Synonyms
Cntfralpha
Feature Type
protein coding gene
Genetic Map
Chromosome 4
21.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr4:41657498-41697089 bp, - strand
From VEGA annotation of GRCm38

  39592 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9619  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CNTFR
Protein SuperFamily: ciliary neurotrophic factor receptor-like protein
Gene Tree: Cntfr

Human
homologs
CNTFR, ciliary neurotrophic factor receptor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1271
neXtProt AC: NX_P26992

Human Chr (Location): 9p13; chr9:34551432-34590140 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(33) Targeted(6)
Incidental mutations (data from Mutagenetix )
 
Homozygous mutant animals exhibit a significant reduction in the number of motor neurons. Neonatal mutants fail to suckle and die within 24 hours after birth.
 
Interactions
Cntfr interacts with 211 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (87)    Tissues (87)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 66
RT-PCR 21
cDNA source data(17)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cntfr ; ZFIN cntfr    NEW 
Molecular
reagents
All nucleic(26) Genomic(3) cDNA(20) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000006676 (Evidence)
Ensembl Gene Model ENSMUSG00000028444 (Evidence)
Entrez Gene 12804 (Evidence)
UniGene 425178
DFCI TC1584718, TC1594688
DoTS DT.101365949, DT.40137927, DT.55171368
NIA Mouse Gene Index U024975
Consensus CDS Project CCDS18067.1, CCDS51142.1
International Mouse Phenotyping Consortium Status Cntfr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006676 VEGA Gene Model | MGI Sequence Detail 39592 C57BL/6J ±  kb
transcript OTTMUST00000015290 VEGA | MGI Sequence Detail 1995 Not Applicable 
polypeptide OTTMUSP00000007063 VEGA | MGI Sequence Detail 372 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(18) UniProt(5)
Polymorphisms
RFLP(3) : SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013151 Immunoglobulin
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR003530 Long hematopoietin receptor, soluble alpha chain, conserved site
Protein Ontology PR:000005664 ciliary neurotrophic factor receptor subunit alpha
References
(Earliest) J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
(Latest) J:202165 Lee N, et al., The contribution of ciliary neurotrophic factor receptors to adult motor neuron survival in vivo is specific to insult type and distinct from that for embryonic motor neurons. J Comp Neurol. 2013 Oct 1;521(14):3217-25
All references(61)
Other
accession IDs
MGD-MRK-16390

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory