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Glp1r Gene Detail
Summary
  • Symbol
    Glp1r
  • Name
    glucagon-like peptide 1 receptor
  • Synonyms
    GLP-1R, GLP1Rc
  • Feature Type
    protein coding gene
  • IDs
    MGI:99571
    NCBI Gene: 14652
Location & Maps
more
  • Sequence Map
    Chr17:30901867-30936510 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34644 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 15.80 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GLP1R, glucagon like peptide 1 receptor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GLP1R, glucagon like peptide 1 receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GLP-1, GLP-1R, GLP-1-R
  • Links
    NCBI Gene ID: 2740
    neXtProt AC: NX_P43220

  • Chr Location
    6p21; chr6:39048781-39091303 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Glucose tolerance and pancreatic secretion is impaired in homozygous null mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14652 NCBI Gene Model | MGI Sequence Detail 34644 C57BL/6J ±  kb
transcript NM_021332 RefSeq | MGI Sequence Detail 1480 C57BL/6  
polypeptide O35659 UniProt | EBI | MGI Sequence Detail 463 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    277 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008040 glucagon-like peptide 1 receptor
  • InterPro Domains
    IPR001879 GPCR, family 2, extracellular hormone receptor domain
    IPR003290 GPCR, family 2, glucagon-like peptide-1/glucagon receptor
    IPR003292 GPCR, family 2, glucagon-like peptide-1 receptor
    IPR017981 GPCR, family 2-like
    IPR000832 GPCR, family 2, secretin-like
    IPR017983 GPCR, family 2, secretin-like, conserved site
Molecular
Reagents
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  • All nucleic 11
    cDNA 8
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-16352
References
more
  • Summaries
    All 113
    Developmental Gene Expression 7
    Gene Ontology 9
    Phenotypes 76
  • Earliest
    J:18259 Campos RV, et al., Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Endocrinology. 1994 May;134(5):2156-64
  • Latest
    J:232319 Williams EK, et al., Sensory Neurons that Detect Stretch and Nutrients in the Digestive System. Cell. 2016 May 25;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory