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Glp1r
Gene Detail
Symbol

Name
ID
Glp1r
glucagon-like peptide 1 receptor
MGI:99571
Synonyms
GLP-1R, GLP1Rc
Feature Type
protein coding gene
Genetic Map
Chromosome 17
15.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:30901867-30936510 bp, + strand
From NCBI annotation of GRCm38

  34644 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1558  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Glp1r

Human
homologs
Human Homolog GLP1R, glucagon-like peptide 1 receptor
NCBI Gene ID 2740
neXtProt AC  NX_P43220
Human Chr (Location)  6p21; chr6:39048781-39088881 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Glucose tolerance and pancreatic secretion is impaired in homozygous null mice.
 
Interactions
Glp1r interacts with 20 markers (Mir25, Mir150, Mir188, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (58)    Tissues (28)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
RT-PCR 53
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(8) Primer pair(3)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000024027 (Evidence)
Entrez Gene14652 (Evidence)
UniGene390969
DFCITC1598708
DoTSDT.91443883
NIA Mouse Gene IndexU017789
Consensus CDS ProjectCCDS37542.1
International Mouse Knockout Project StatusGlp1r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14652 NCBI Gene Model | MGI Sequence Detail 34644 C57BL/6J ±  kb
transcript NM_021332 RefSeq | MGI Sequence Detail 1480 C57BL/6 
polypeptide O35659 UniProt | EBI | MGI Sequence Detail 463 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(282 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR003290 GPCR, family 2, glucagon-like peptide-1/glucagon receptor
InterPro IPR003292 GPCR, family 2, glucagon-like peptide-1 receptor
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000008040 glucagon-like peptide 1 receptor
Graphical View of Protein Domain Structure
References
(Earliest) J:18259 Campos RV, et al., Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Endocrinology. 1994 May;134(5):2156-64
(Latest) J:209002 Nguyen AT, et al., Lipopolysaccharides-mediated increase in glucose-stimulated insulin secretion: involvement of the GLP-1 pathway. Diabetes. 2014 Feb;63(2):471-82
All references(96)
Other
accession IDs
MGD-MRK-16352

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory