Glp1r
Gene Detail

Symbol Name ID

Glp1r glucagon-like peptide 1 receptor MGI:99571

Synonyms

GLP-1R, GLP1Rc

Feature Type

protein coding gene

Genetic Map

Chromosome 17

15.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr17:30901867-30936510 bp, + strand From NCBI annotation of GRCm38   34644 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1558  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Glp1r

Human homologs

Human Homolog		GLP1R, glucagon-like peptide 1 receptor
NCBI Gene ID		2740
neXtProt AC		NX_P43220
Human Chr (Location)		6p21; chr6:39016557-39055520 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Glucose tolerance and pancreatic secretion is impaired in homozygous null mice.

 

Gene Ontology (GO) classifications

All GO classifications: (44 annotations)

Process	adenylate cyclase-activating G-protein coupled receptor signaling pathway, associative learning, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	glucagon receptor activity, G-protein coupled peptide receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (58)    Tissues (27)    Images (6)
Theiler Stages: 23, 25, 26, 28

Assay Type	Results
RNA in situ	5
RT-PCR	53

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(8) Primer pair(3)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000024027 (Evidence)
Entrez Gene	14652 (Evidence)
UniGene	390969
DFCI	TC1598708
DoTS	DT.91443883
NIA Mouse Gene Index	U017789
Consensus CDS Project	CCDS37542.1
International Mouse Knockout Project Status	Glp1r

Sequences

Length	Strain/Species
genomic	14652	NCBI Gene Model | MGI Sequence Detail	34644	C57BL/6J
transcript	NM_021332	RefSeq | MGI Sequence Detail	1480	C57BL/6
polypeptide	O35659	UniProt | EBI | MGI Sequence Detail	489	Not Applicable

All sequences(24) RefSeq(2) UniProt(5)

Polymorphisms

PCR(1) : SNPs(178 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001879	GPCR, family 2, extracellular hormone receptor domain
InterPro	IPR003290	GPCR, family 2, glucagon-like peptide-1/glucagon receptor
InterPro	IPR003292	GPCR, family 2, glucagon-like peptide-1 receptor
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR017983	GPCR, family 2, secretin-like, conserved site
Protein Ontology	PR:000008040	glucagon-like peptide 1 receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:18259 Campos RV, et al., Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Endocrinology. 1994 May;134(5):2156-64
(Latest) J:194207 Panjwani N, et al., GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice. Endocrinology. 2013 Jan;154(1):127-39
All references(86)

Other accession IDs

MGD-MRK-16352