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Hoxc13
Gene Detail
Symbol

Name
ID
Member of
Hoxc13
homeobox C13
MGI:99560
Hoxc cluster
Feature Type
protein coding gene
Genetic Map
Chromosome 15
57.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:102921103-102928814 bp, + strand
From VEGA annotation of GRCm38

  7712 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7770  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HOXC13
Gene Tree: Hoxc13

Human
homologs
HOXC13, homeobox C13
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3229
neXtProt AC: NX_P31276

Human Synonyms: ECTD9, HOX3, HOX3G

Human Chr (Location): 12q13.3; chr12:53938792-53946544 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HOXC13

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Radiation induced(1) Targeted(7) Transgenic(1)
Genomic Mutations involving Hoxc13 (1)
Incidental mutations (data from CvDC )
 
Homozygotes for targeted null mutations exhibit alopecia due to brittle hair, poor growth, abnormalities of caudal vertebrae, nails, and tongue filiform papillae, and lethality in the second week. Rare survivors recover, but lack hair.
 
Phenotype Images(2)
Interactions
Hoxc13 interacts with 249 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process anatomical structure morphogenesis, anterior/posterior pattern specification, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (59)    Tissues (36)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 39
RT-PCR 20
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hoxc13 ; ZFIN hoxc13a, hoxc13b    NEW 
Molecular
reagents
All nucleic(18) Genomic(3) cDNA(10) Primer pair(4) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000037392 (Evidence)
Ensembl Gene Model ENSMUSG00000001655 (Evidence)
Entrez Gene 15422 (Evidence)
UniGene 207062
DFCI TC1591398
DoTS DT.527548
Consensus CDS Project CCDS27890.1
International Mouse Phenotyping Consortium Status Hoxc13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037392 VEGA Gene Model | MGI Sequence Detail 7712 C57BL/6J ±  kb
transcript OTTMUST00000096494 VEGA | MGI Sequence Detail 2461 Not Applicable 
polypeptide OTTMUSP00000053922 VEGA | MGI Sequence Detail 328 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(3) UniProt(1)
Polymorphisms
SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeobox domain
InterPro IPR022067 Homeobox protein Hox1A3 N-terminal
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000008710 homeobox protein Hox-C13
References
(Earliest) J:19418 Bradshaw MS, et al., Identification of the murine Hox-c12 and Hox-c13 homeoboxes on yeast artificial chromosomes. Genomics. 1994 Jul 1;22(1):234-6
(Latest) J:204667 Min H, et al., Hoxc gene collinear expression and epigenetic modifications established during embryogenesis are maintained until after birth. Int J Biol Sci. 2013;9(9):960-5
All references(49)
Other
accession IDs
MGD-MRK-16338

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory