Hoxc13
Gene Detail

Symbol Name ID

Hoxc13 homeobox C13 MGI:99560

Feature Type

protein coding gene

Genetic Map

Chromosome 15

57.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:102921103-102928814 bp, + strand From VEGA annotation of GRCm38   7712 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7770  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Hoxc13

Human homologs

Human Homolog		HOXC13, homeobox C13
NCBI Gene ID		3229
neXtProt AC		NX_P31276
Human Synonyms		ECTD9, HOX3, HOX3G
Human Chr (Location)		12q13.3; chr12:54332576-54340328 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HOXC13

Alleles and phenotypes

All alleles(8) : Targeted(7) Gene trapped(1)
 

Homozygotes for targeted null mutations exhibit alopecia due to brittle hair, poor growth, abnormalities of caudal vertebrae, nails, and tongue filiform papillae, and lethality in the second week. Rare survivors recover, but lack hair.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	anatomical structure morphogenesis, anterior/posterior pattern specification, ...
Component	nucleus
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (22 records)
Data Summary: Results (59)    Tissues (35)    Images (20)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	39
RT-PCR	20

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) Genomic(3) cDNA(10) Primer pair(4) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000037392 (Evidence)
Ensembl Gene Model	ENSMUSG00000001655 (Evidence)
Entrez Gene	15422 (Evidence)
UniGene	207062
DFCI	TC1591398
DoTS	DT.527548
Consensus CDS Project	CCDS27890.1
International Mouse Knockout Project Status	Hoxc13

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037392	VEGA Gene Model | MGI Sequence Detail	7712	C57BL/6J
transcript	OTTMUST00000096494	VEGA | MGI Sequence Detail	2461	Not Applicable
polypeptide	OTTMUSP00000053922	VEGA | MGI Sequence Detail	328	Not Applicable

All sequences(16) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(7 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR022067	Homeobox protein Hox1A3 N-terminal
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
Protein Ontology	PR:000008710	homeobox protein Hox-C13

References

(Earliest) J:19418 Bradshaw MS, et al., Identification of the murine Hox-c12 and Hox-c13 homeoboxes on yeast artificial chromosomes. Genomics. 1994 Jul 1;22(1):234-6
(Latest) J:182085 Potter CS, et al., The nude mutant gene Foxn1 is a HOXC13 regulatory target during hair follicle and nail differentiation. J Invest Dermatol. 2011 Apr;131(4):828-37
All references(49)

Other accession IDs

MGD-MRK-16338