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Hoxc13
Gene Detail
 Symbol
Name
ID
Member of
Hoxc13
homeobox C13
MGI:99560
Hoxc cluster
Feature Type protein coding gene
Genetic Map
Chromosome 15
57.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:102921103-102928814 bp, + strand
From VEGA annotation of GRCm38

  7712 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7770  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Hoxc13

Human
homologs
Human Homolog HOXC13, homeobox C13
NCBI Gene ID 3229
neXtProt AC  NX_P31276
Human Synonyms  ECTD9, HOX3, HOX3G
Human Chr (Location)  12q13.3; chr12:53938792-53946544 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HOXC13
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Radiation induced(1) Targeted(7)
Genomic Mutations involving Hoxc13 (1)
 
Homozygotes for targeted null mutations exhibit alopecia due to brittle hair, poor growth, abnormalities of caudal vertebrae, nails, and tongue filiform papillae, and lethality in the second week. Rare survivors recover, but lack hair.
 
Interactions
Hoxc13 interacts with 249 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process anatomical structure morphogenesis, anterior/posterior pattern specification, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (59)    Tissues (35)    Images (20)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 39
RT-PCR 20
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(3) cDNA(10) Primer pair(4) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000037392 (Evidence)
Ensembl Gene ModelENSMUSG00000001655 (Evidence)
Entrez Gene15422 (Evidence)
UniGene207062
DFCITC1591398
DoTSDT.527548
Consensus CDS ProjectCCDS27890.1
International Mouse Knockout Project StatusHoxc13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037392 VEGA Gene Model | MGI Sequence Detail 7712 C57BL/6J ±  kb
transcript OTTMUST00000096494 VEGA | MGI Sequence Detail 2461 Not Applicable 
polypeptide OTTMUSP00000053922 VEGA | MGI Sequence Detail 328 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(3) UniProt(1)
Polymorphisms SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR022067 Homeobox protein Hox1A3 N-terminal
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000008710 homeobox protein Hox-C13
References (Earliest) J:19418 Bradshaw MS, et al., Identification of the murine Hox-c12 and Hox-c13 homeoboxes on yeast artificial chromosomes. Genomics. 1994 Jul 1;22(1):234-6
(Latest) J:182085 Potter CS, et al., The nude mutant gene Foxn1 is a HOXC13 regulatory target during hair follicle and nail differentiation. J Invest Dermatol. 2011 Apr;131(4):828-37
All references(49)
Other
accession IDs
MGD-MRK-16338

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory