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Hoxc13 Gene Detail
Summary
  • Symbol
    Hoxc13
  • Name
    homeobox C13
  • Feature Type
    protein coding gene
  • IDs
    MGI:99560
    NCBI Gene: 15422
  • Member of
    Hoxc cluster
  • Gene Overview
    MyGene.info: HOXC13
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:102921131-102928814 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 57.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99560
protein coding gene Chr15:102921103-102928814 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022424
protein coding gene Chr15:105155371-105163078 (+)
A/J MGP_AJ_G0022386
protein coding gene Chr15:100999798-101007603 (+)
AKR/J MGP_AKRJ_G0022361
protein coding gene Chr15:104069070-104076767 (+)
BALB/cJ MGP_BALBcJ_G0022390
protein coding gene Chr15:101047145-101054856 (+)
C3H/HeJ MGP_C3HHeJ_G0022157
protein coding gene Chr15:104144523-104152928 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022839
protein coding gene Chr15:109047774-109057225 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020362
protein coding gene Chr15:96769350-96777179 (+)
CAST/EiJ MGP_CASTEiJ_G0021683
protein coding gene Chr15:105015504-105025127 (+)
CBA/J MGP_CBAJ_G0022126
protein coding gene Chr15:112882663-112890374 (+)
DBA/2J MGP_DBA2J_G0022257
protein coding gene Chr15:100269937-100277676 (+)
FVB/NJ MGP_FVBNJ_G0022233
protein coding gene Chr15:99339465-99347150 (+)
LP/J MGP_LPJ_G0022326
protein coding gene Chr15:105290987-105298694 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022255
protein coding gene Chr15:116399253-116406950 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022851
protein coding gene Chr15:104107798-104115510 (+)
PWK/PhJ MGP_PWKPhJ_G0021423
protein coding gene Chr15:100448202-100456335 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021255
protein coding gene Chr15:103936809-103945457 (+)
WSB/EiJ MGP_WSBEiJ_G0021733
protein coding gene Chr15:104722292-104729853 (+)



Homology
more
  • Human Ortholog
    HOXC13, homeobox C13
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HOXC13, homeobox C13
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ECTD9, HOX3, HOX3G
  • Links
    NCBI Gene ID: 3229
    neXtProt AC: NX_P31276
    UniProt: P31276

  • Chr Location
    12q13.13; chr12:53938792-53946544 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 6 alleles in 5 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit alopecia due to brittle hair, poor growth, abnormalities of caudal vertebrae, nails, and tongue filiform papillae, and lethality in the second week. Rare survivors recover, but lack hair.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15422 NCBI Gene Model | MGI Sequence Detail 7684 C57BL/6J ±  kb
    transcript NM_010464 RefSeq | MGI Sequence Detail 2433 C57BL/6  
    polypeptide P50207 UniProt | EBI | MGI Sequence Detail 328 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 3
      cDNA 12
      Primer pair 5
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-16338
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 34
      Diseases 1
      Gene Ontology 4
      Phenotypes 30
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:247259 Naruse C, et al., New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. FASEB J. 2017 Jun;31(6):2252-2266

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory