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Mfap2 Gene Detail
Summary
  • Symbol
    Mfap2
  • Name
    microfibrillar-associated protein 2
  • Synonyms
    Magp
  • Feature Type
    protein coding gene
  • IDs
    MGI:99559
    NCBI Gene: 17150
  • Gene Overview
    MyGene.info: MFAP2
Location & Maps
more
  • Sequence Map
    Chr4:141010418-141015984 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5567 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 73.31 cM, cytoband D3-E1
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MFAP2, microfibrillar associated protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MFAP2, microfibrillar associated protein 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MAGP, MAGP1, MAGP-1
  • Links
    NCBI Gene ID: 4237
    neXtProt AC: NX_P55001

  • Chr Location
    1p36.1-p35; chr1:16974500-16981643 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Targeted
    4
  • Genomic Mutations
    3 involving Mfap2
  • Incidental Mutations
Mice homozygous for a knock-out allele display a decreased platelet number, delayed thrombotic occlusion following carotid artery injury, and prolonged bleeding from a tail vein incision.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010084 VEGA Gene Model | MGI Sequence Detail 5567 C57BL/6J ±  kb
transcript OTTMUST00000097557 VEGA | MGI Sequence Detail 890 Not Applicable  
polypeptide OTTMUSP00000054726 VEGA | MGI Sequence Detail 185 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    60 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010361 microfibrillar-associated protein 2
  • InterPro Domains
    IPR008673 Microfibril-associated glycoprotein
    IPR003582 ShKT domain
Molecular
Reagents
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  • All nucleic 88
    Genomic 1
    cDNA 85
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-16337, MGI:2140404
References
more
  • Summaries
    All 45
    Developmental Gene Expression 14
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:16038 Chen Y, et al., Structure, chromosomal localization, and expression pattern of the murine Magp gene. J Biol Chem. 1993 Dec 25;268(36):27381-9
  • Latest
    J:229439 Mecham RP, et al., The microfibril-associated glycoproteins (MAGPs) and the microfibrillar niche. Matrix Biol. 2015 Sep;47:13-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory