About   Help   FAQ
Mfap2
Gene Detail
 Symbol
Name
ID
Mfap2
microfibrillar-associated protein 2
MGI:99559
Synonyms Magp
Feature Type protein coding gene
Genetic Map
Chromosome 4
73.31 cM, cytoband D3-E1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:141010418-141015984 bp, + strand
From VEGA annotation of GRCm38

  5567 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1801  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: microfibrillar-associated protein , MFAP2 type
Gene Tree: Mfap2

Human
homologs
Human Homolog MFAP2, microfibrillar-associated protein 2
NCBI Gene ID 4237
neXtProt AC  NX_P55001
Human Synonyms  MAGP, MAGP1, MAGP-1
Human Chr (Location)  1p36.1-p35; chr1:16974502-16981586 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display a decreased platelet number, delayed thrombotic occlusion following carotid artery injury, and prolonged bleeding from a tail vein incision.
 
Interactions
Mfap2 interacts with 72 markers (Mir29a, Mir29b-1, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process platelet formation
Component extracellular region, microfibril, ...
Function fibrinogen binding, fibronectin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (135)    Tissues (93)    Images (44)
Theiler Stages: 11, 13, 17, 19, 20, 22, 23, 24, 28
Assay TypeResults
RNA in situ 135
cDNA source data(85)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(88) Genomic(1) cDNA(85) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000010084 (Evidence)
Ensembl Gene ModelENSMUSG00000060572 (Evidence)
Entrez Gene17150 (Evidence)
UniGene7386
DFCITC1577584
DoTSDT.102519911, DT.103585072, DT.535197
NIA Mouse Gene IndexU005031
Consensus CDS ProjectCCDS18860.2
International Mouse Knockout Project StatusMfap2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010084 VEGA Gene Model | MGI Sequence Detail 5567 C57BL/6J ±  kb
transcript OTTMUST00000097557 VEGA | MGI Sequence Detail 890 Not Applicable 
polypeptide OTTMUSP00000054726 VEGA | MGI Sequence Detail 185 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(12) UniProt(2)
Polymorphisms SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003582 Metridin-like ShK toxin
InterPro IPR008673 Microfibril-associated glycoprotein
Protein Ontology PR:000010361 microfibrillar-associated protein 2
References (Earliest) J:16038 Chen Y, et al., Structure, chromosomal localization, and expression pattern of the murine Magp gene. J Biol Chem. 1993 Dec 25;268(36):27381-9
(Latest) J:203960 Combs MD, et al., Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo. J Biol Chem. 2013 Oct 4;288(40):28869-80
All references(44)
Other
accession IDs
MGD-MRK-16337, MGI:2140404

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory