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Mfap2 Gene Detail
Summary
  • Symbol
    Mfap2
  • Name
    microfibrillar-associated protein 2
  • Synonyms
    Magp
  • Feature Type
    protein coding gene
  • IDs
    MGI:99559
    NCBI Gene: 17150
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:140737735-140743286 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 73.31 cM, cytoband D3-E1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99559
protein coding gene Chr4:140737729-140743295 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029035
protein coding gene Chr4:144001611-144007194 (+)
A/J MGP_AJ_G0028994
protein coding gene Chr4:137771162-137776728 (+)
AKR/J MGP_AKRJ_G0028946
protein coding gene Chr4:141741568-141747134 (+)
BALB/cJ MGP_BALBcJ_G0029018
protein coding gene Chr4:138459742-138465308 (+)
C3H/HeJ MGP_C3HHeJ_G0028732
protein coding gene Chr4:142125588-142131154 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029459
protein coding gene Chr4:149059921-149065487 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026730
protein coding gene Chr4:130684490-130690354 (+)
CAST/EiJ MGP_CASTEiJ_G0028164
protein coding gene Chr4:140376605-140382208 (+)
CBA/J MGP_CBAJ_G0028696
protein coding gene Chr4:153350180-153355746 (+)
DBA/2J MGP_DBA2J_G0028846
protein coding gene Chr4:138164099-138169683 (+)
FVB/NJ MGP_FVBNJ_G0028813
protein coding gene Chr4:137267218-137273139 (+)
LP/J MGP_LPJ_G0028945
protein coding gene Chr4:144034858-144040441 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028839
protein coding gene Chr4:157211883-157218548 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029497
protein coding gene Chr4:142265504-142272172 (+)
PWK/PhJ MGP_PWKPhJ_G0027885
protein coding gene Chr4:135047782-135053358 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027710
protein coding gene Chr4:138095954-138101534 (+)
WSB/EiJ MGP_WSBEiJ_G0028242
protein coding gene Chr4:142548679-142554262 (+)



Homology
more
  • Human Ortholog
    MFAP2, microfibril associated protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MFAP2, microfibril associated protein 2
  • Synonyms
    MAGP, MAGP1, MAGP-1
  • Links
    NCBI Gene ID: 4237
    neXtProt AC: NX_P55001
    UniProt: P55001

  • Chr Location
    1p36.13; chr1:16974502-16981583 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a knock-out allele show thrombocytopenia, delayed thrombotic occlusion following vessel injury, and prolonged bleeding from a tail vein incision. Homozygotes for a different knock-out allele exhibit marrow adipose tissue expansion, insulin resistance, and altered basal hematopoiesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17150 NCBI Gene Model | MGI Sequence Detail 5552 C57BL/6J ±  kb
    transcript NM_001421243 RefSeq | MGI Sequence Detail 1269 C57BL/6  
    polypeptide P55002 UniProt | EBI | MGI Sequence Detail 183 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      Genomic 1
      cDNA 86
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16337, MGI:2140404
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 19
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:16038 Chen Y, et al., Structure, chromosomal localization, and expression pattern of the murine Magp gene. J Biol Chem. 1993 Dec 25;268(36):27381-9
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory