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Pde4b
Gene Detail
 Symbol
Name
ID
Pde4b
phosphodiesterase 4B, cAMP specific
MGI:99557
Synonyms Dpde4, dunce
Feature Type protein coding gene
Genetic Map
Chromosome 4
46.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:102087543-102607259 bp, + strand
From VEGA annotation of GRCm38

  519717 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1953  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 3',5'-cyclic-nucleotide phosphodiesterase 1B, calmodulin-dependent
Gene Tree: Pde4b

Human
homologs
Human Homolog PDE4B, phosphodiesterase 4B, cAMP-specific
NCBI Gene ID 5142
neXtProt AC  NX_Q07343
Human Synonyms  DPDE4, PDEIVB
Human Chr (Location)  1p31; chr1:65792510-66374579 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene produce significantly less TNF-alpha in response to lipopolysaccharide stimulation. One mutation resulted in brain and spinal cord vacuoles.
 
Interactions
Pde4b interacts with 336 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cAMP catabolic process, cellular response to drug, ...
Component cell periphery, cytoplasm, ...
Function 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (118)    Tissues (104)    Images (29)
Theiler Stages: 17, 21, 22, 23
Assay TypeResults
RNA in situ 116
RT-PCR 2
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) Genomic(16) cDNA(23) Primer pair(2) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000008053 (Evidence)
Ensembl Gene ModelENSMUSG00000028525 (Evidence)
Entrez Gene18578 (Evidence)
DFCITC1578713, TC1588849, TC1590011, TC1596445, TC1596512, TC1601996, TC1611312, TC1617134, TC1629586
DoTSDT.101399217, DT.101399222, DT.101708337, DT.101717301, DT.103566849, DT.110815308, DT.488566, DT.529111, DT.87040472, DT.99844366, DT.99870976
NIA Mouse Gene IndexU004556
Consensus CDS ProjectCCDS18403.1, CCDS51243.1, CCDS51244.1, CCDS51245.1, CCDS57289.1
International Mouse Knockout Project StatusPde4b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008053 VEGA Gene Model | MGI Sequence Detail 519717 C57BL/6J ±  kb
transcript OTTMUST00000018212 VEGA | MGI Sequence Detail 3020 Not Applicable 
polypeptide OTTMUSP00000008358 VEGA | MGI Sequence Detail 736 Not Applicable 

For the selected sequences
All sequences(136) RefSeq(18) UniProt(17)
Polymorphisms RFLP(1) : SNPs within 2kb(3886 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3894)
Protein-related
information
ResourceIDDescription
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR003607 HD/PDEase domain
Protein Ontology PR:000012473 cAMP-specific 3',5'-cyclic phosphodiesterase 4B
References (Earliest) J:18405 Milatovich A, et al., Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. Somat Cell Mol Genet. 1994 Mar;20(2):75-86
(Latest) J:203118 Iwata J, et al., Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice. Hum Mol Genet. 2014 Jan 1;23(1):182-93
All references(54)
Other
accession IDs
MGD-MRK-16335, MGI:2140715

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory