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Pde4b Gene Detail
Summary
  • Symbol
    Pde4b
  • Name
    phosphodiesterase 4B, cAMP specific
  • Synonyms
    Dpde4, dunce
  • Feature Type
    protein coding gene
  • IDs
    MGI:99557
    NCBI Gene: 18578
  • Gene Overview
    MyGene.info: PDE4B
  • Alliance
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:102087543-102607259 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 46.99 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3872 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99557
protein coding gene Chr4:102087528-102607262 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028500
protein coding gene Chr4:102436844-102995196 (+)
A/J MGP_AJ_G0028463
protein coding gene Chr4:98867360-99406528 (+)
AKR/J MGP_AKRJ_G0028410
protein coding gene Chr4:101243125-101813322 (+)
BALB/cJ MGP_BALBcJ_G0028482
protein coding gene Chr4:99056373-99603938 (+)
C3H/HeJ MGP_C3HHeJ_G0028196
protein coding gene Chr4:102040773-102596594 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028922
protein coding gene Chr4:106295566-106880648 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026213
protein coding gene Chr4:94258266-94777042 (+)
CAST/EiJ MGP_CASTEiJ_G0027632
protein coding gene Chr4:99795133-100356929 (+)
CBA/J MGP_CBAJ_G0028165
protein coding gene Chr4:109650984-110263186 (+)
DBA/2J MGP_DBA2J_G0028313
protein coding gene Chr4:98541647-99068829 (+)
FVB/NJ MGP_FVBNJ_G0028280
protein coding gene Chr4:97395748-97924065 (+)
LP/J MGP_LPJ_G0028414
protein coding gene Chr4:102751487-103314140 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028307
protein coding gene Chr4:115162664-115751506 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028957
protein coding gene Chr4:101477887-102022115 (+)
PWK/PhJ MGP_PWKPhJ_G0027358
protein coding gene Chr4:96740803-97275822 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027182
protein coding gene Chr4:98898348-99454070 (+)
WSB/EiJ MGP_WSBEiJ_G0027712
protein coding gene Chr4:101658025-102204559 (+)



Homology
more
  • Human Ortholog
    PDE4B, phosphodiesterase 4B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDE4B, phosphodiesterase 4B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DPDE4, PDEIVB
  • Links
    NCBI Gene ID: 5142
    neXtProt AC: NX_Q07343
    UniProt: Q07343

  • Chr Location
    1p31.3; chr1:65792510-66374579 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene produce significantly less TNF-alpha in response to lipopolysaccharide stimulation. One mutation resulted in brain and spinal cord vacuoles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028525 Ensembl Gene Model | MGI Sequence Detail 519717 C57BL/6J ±  kb
    transcript ENSMUST00000106911 Ensembl | MGI Sequence Detail 3020 Not Applicable  
    polypeptide ENSMUSP00000102524 Ensembl | MGI Sequence Detail 736 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      17 Sequences
    • EC
    • InterPro Domains
      IPR023088 3'5'-cyclic nucleotide phosphodiesterase
      IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
      IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
      IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
      IPR003607 HD/PDEase domain
      IPR040844 Phosphodiesterase 4 upstream conserved regions (UCR)
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 16
      cDNA 24
      Primer pair 2
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-16335, MGI:2140715
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 7
      Gene Ontology 11
      Phenotypes 25
    • Earliest
      J:18405 Milatovich A, et al., Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. Somat Cell Mol Genet. 1994 Mar;20(2):75-86
    • Latest
      J:266193 Pleiman JK, et al., The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer. PLoS Genet. 2018 Sep;14(9):e1007611

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory