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Pde4b
Gene Detail
Symbol

Name
ID
Pde4b
phosphodiesterase 4B, cAMP specific
MGI:99557
Synonyms
Dpde4, dunce
Feature Type
protein coding gene
Genetic Map
Chromosome 4
46.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:102087543-102607259 bp, + strand
From VEGA annotation of GRCm38

  519717 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1953  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 3',5'-cyclic-nucleotide phosphodiesterase 1B, calmodulin-dependent
Gene Tree: Pde4b

Human
homologs
Human Homolog PDE4B, phosphodiesterase 4B, cAMP-specific
NCBI Gene ID 5142
neXtProt AC  NX_Q07343
Human Synonyms  DPDE4, PDEIVB
Human Chr (Location)  1p31; chr1:65792510-66374579 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene produce significantly less TNF-alpha in response to lipopolysaccharide stimulation. One mutation resulted in brain and spinal cord vacuoles.
 
Interactions
Pde4b interacts with 336 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (118)    Tissues (104)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 116
RT-PCR 2
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) Genomic(16) cDNA(23) Primer pair(2) Other(1)
Microarray probesets(7)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008053 VEGA Gene Model | MGI Sequence Detail 519717 C57BL/6J ±  kb
transcript OTTMUST00000018212 VEGA | MGI Sequence Detail 3020 Not Applicable 
polypeptide OTTMUSP00000008358 VEGA | MGI Sequence Detail 736 Not Applicable 

For the selected sequences
All sequences(136) RefSeq(18) UniProt(17)
Polymorphisms
RFLP(1) : SNPs within 2kb(3886 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3894)
Protein-related
information
ResourceIDDescription
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR003607 HD/PDEase domain
Protein Ontology PR:000012473 cAMP-specific 3',5'-cyclic phosphodiesterase 4B
References
(Earliest) J:18405 Milatovich A, et al., Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. Somat Cell Mol Genet. 1994 Mar;20(2):75-86
(Latest) J:203118 Iwata J, et al., Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice. Hum Mol Genet. 2014 Jan 1;23(1):182-93
All references(54)
Other
accession IDs
MGD-MRK-16335, MGI:2140715

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory