Pde4b
Gene Detail

Symbol Name ID

Pde4b phosphodiesterase 4B, cAMP specific MGI:99557

Synonyms

Dpde4, dunce

Feature Type

protein coding gene

Genetic Map

Chromosome 4

46.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr4:102087543-102607259 bp, + strand From VEGA annotation of GRCm38   519717 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1953  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 3',5'-cyclic-nucleotide phosphodiesterase 1B, calmodulin-dependent
Gene Tree: Pde4b

Human homologs

Human Homolog		PDE4B, phosphodiesterase 4B, cAMP-specific
NCBI Gene ID		5142
neXtProt AC		NX_Q07343
Human Synonyms		DPDE4, PDE4B5, PDEIVB
Human Chr (Location)		1p31; chr1:66258193-66840262 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions in this gene produce significantly less TNF-alpha in response to lipopolysaccharide stimulation. One mutation resulted in brain and spinal cord vacuoles.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	cAMP catabolic process, cellular response to drug, ...
Component	cell periphery, cytoplasm, ...
Function	3',5'-cyclic-AMP phosphodiesterase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (118)    Tissues (104)    Images (29)
Theiler Stages: 17, 21, 22, 23

Assay Type	Results
RNA in situ	116
RT-PCR	2

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) Genomic(16) cDNA(23) Primer pair(2) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000008053 (Evidence)
Ensembl Gene Model	ENSMUSG00000028525 (Evidence)
Entrez Gene	18578 (Evidence)
DFCI	TC1578713, TC1588849, TC1590011, TC1596445, TC1596512, TC1601996, TC1611312, TC1617134, TC1629586
DoTS	DT.101399217, DT.101399222, DT.101708337, DT.101717301, DT.103566849, DT.110815308, DT.488566, DT.529111, DT.87040472, DT.99844366, DT.99870976
NIA Mouse Gene Index	U004556
Consensus CDS Project	CCDS18403.1, CCDS51243.1, CCDS51244.1, CCDS51245.1, CCDS57289.1
International Mouse Knockout Project Status	Pde4b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008053	VEGA Gene Model | MGI Sequence Detail	519717	C57BL/6J
transcript	OTTMUST00000018212	VEGA | MGI Sequence Detail	3020	Not Applicable
polypeptide	OTTMUSP00000008358	VEGA | MGI Sequence Detail	736	Not Applicable

All sequences(128) RefSeq(10) UniProt(17)

Polymorphisms

RFLP(1) : SNPs(1964 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023088	3'5'-cyclic nucleotide phosphodiesterase
InterPro	IPR002073	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro	IPR023174	3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro	IPR003607	HD/PDEase domain
Protein Ontology	PR:000012473	cAMP-specific 3',5'-cyclic phosphodiesterase 4B

References

(Earliest) J:18405 Milatovich A, et al., Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. Somat Cell Mol Genet. 1994 Mar;20(2):75-86
(Latest) J:175643 Leroy J, et al., Phosphodiesterase 4B in the cardiac L-type Ca(2) channel complex regulates Ca(2) current and protects against ventricular arrhythmias in mice. J Clin Invest. 2011 Jul 1;121(7):2651-61
All references(51)

Other accession IDs

MGD-MRK-16335, MGI:2140715