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Pde4b Gene Detail
Summary
  • Symbol
    Pde4b
  • Name
    phosphodiesterase 4B, cAMP specific
  • Synonyms
    Dpde4, dunce
  • Feature Type
    protein coding gene
  • IDs
    MGI:99557
    NCBI Gene: 18578
  • Gene Overview
    MyGene.info: PDE4B
Location & Maps
more
  • Sequence Map
    Chr4:102087543-102607259 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      519717 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 46.99 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    PDE4B, phosphodiesterase 4B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDE4B, phosphodiesterase 4B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DPDE4, PDEIVB
  • Links
    NCBI Gene ID: 5142
    neXtProt AC: NX_Q07343

  • Chr Location
    1p31.3; chr1:65792510-66374579 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    4 involving Pde4b
  • Incidental Mutations
Mice homozygous for disruptions in this gene produce significantly less TNF-alpha in response to lipopolysaccharide stimulation. One mutation resulted in brain and spinal cord vacuoles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008053 VEGA Gene Model | MGI Sequence Detail 519717 C57BL/6J ±  kb
transcript OTTMUST00000018212 VEGA | MGI Sequence Detail 3020 Not Applicable  
polypeptide OTTMUSP00000008358 VEGA | MGI Sequence Detail 736 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3872 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    17 Sequences
  • EC
  • InterPro Domains
    IPR023088 3'5'-cyclic nucleotide phosphodiesterase
    IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
    IPR003607 HD/PDEase domain
Molecular
Reagents
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  • All nucleic 42
    Genomic 16
    cDNA 23
    Primer pair 2
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-16335, MGI:2140715
References
more
  • Summaries
    All 53
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 20
  • Earliest
    J:18405 Milatovich A, et al., Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. Somat Cell Mol Genet. 1994 Mar;20(2):75-86
  • Latest
    J:235691 Johanns M, et al., AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B. Nat Commun. 2016;7:10856

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory