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Pde4c
Gene Detail
Symbol

Name
ID
Pde4c
phosphodiesterase 4C, cAMP specific
MGI:99556
Synonyms
Dpde1, dunce, E130301F19Rik, MGC:31320
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.15 cM, cytoband B3-C1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:70723720-70751186 bp, + strand
From VEGA annotation of GRCm38

  27467 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

Protein SuperFamily: 3',5'-cyclic-nucleotide phosphodiesterase 1B, calmodulin-dependent
Gene Tree: Pde4c

Human
homologs
Human Homolog PDE4C, phosphodiesterase 4C, cAMP-specific
NCBI Gene ID 5143
neXtProt AC  NX_Q08493
Human Synonyms  DPDE1
Human Chr (Location)  19p13.11; chr19:18207961-18248200 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix )
Interactions
Pde4c interacts with 118 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(16)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000027334 (Evidence)
Ensembl Gene ModelENSMUSG00000031842 (Evidence)
Entrez Gene110385 (Evidence)
UniGene255180
DoTSDT.40165368, DT.40166043
NIA Mouse Gene IndexU009441
EC3.1.4.53
Consensus CDS ProjectCCDS22378.1
International Mouse Knockout Project StatusPde4c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027334 VEGA Gene Model | MGI Sequence Detail 27467 C57BL/6J ±  kb
transcript OTTMUST00000067570 VEGA | MGI Sequence Detail 3290 Not Applicable 
polypeptide OTTMUSP00000034022 VEGA | MGI Sequence Detail 686 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(284 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR003607 HD/PDEase domain
Protein Ontology PR:000012474 cAMP-specific 3',5'-cyclic phosphodiesterase 4C
References
(Earliest) J:18405 Milatovich A, et al., Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. Somat Cell Mol Genet. 1994 Mar;20(2):75-86
(Latest) J:200285 Tian G, et al., Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion. J Cell Sci. 2012 Nov 1;125(Pt 21):5084-95
All references(39)
Other
accession IDs
MGD-MRK-16334, MGI:3036271

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory