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Pde4c Gene Detail
Summary
  • Symbol
    Pde4c
  • Name
    phosphodiesterase 4C, cAMP specific
  • Synonyms
    Dpde1, dunce, E130301F19Rik, MGC:31320
  • Feature Type
    protein coding gene
  • IDs
    MGI:99556
    NCBI Gene: 110385
  • Gene Overview
    MyGene.info: PDE4C
Location & Maps
more
  • Sequence Map
    Chr8:70723720-70751186 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27467 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.15 cM, cytoband B3-C1
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    PDE4C, phosphodiesterase 4C
  • Vertebrate Orthologs
    5
  • Human Ortholog
    PDE4C, phosphodiesterase 4C
    Orthology source: HomoloGene
  • Synonyms
    DPDE1
  • Links
    NCBI Gene ID: 5143
    neXtProt AC: NX_Q08493

  • Chr Location
    19p13.11; chr19:18207961-18248200 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Pde4c
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027334 VEGA Gene Model | MGI Sequence Detail 27467 C57BL/6J ±  kb
transcript OTTMUST00000067570 VEGA | MGI Sequence Detail 3290 Not Applicable  
polypeptide OTTMUSP00000034022 VEGA | MGI Sequence Detail 686 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    282 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012474 cAMP-specific 3',5'-cyclic phosphodiesterase 4C
  • EC
  • InterPro Domains
    IPR023088 3'5'-cyclic nucleotide phosphodiesterase
    IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
    IPR003607 HD/PDEase domain
Molecular
Reagents
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  • All nucleic 17
    Genomic 1
    cDNA 16

    Microarray probesets 1
Other
Accession IDs
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MGD-MRK-16334, MGI:3036271
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:18405 Milatovich A, et al., Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. Somat Cell Mol Genet. 1994 Mar;20(2):75-86
  • Latest
    J:200285 Tian G, et al., Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion. J Cell Sci. 2012 Nov 1;125(Pt 21):5084-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory