Pde4c
Gene Detail

Symbol Name ID

Pde4c phosphodiesterase 4C, cAMP specific MGI:99556

Synonyms

Dpde1, dunce, E130301F19Rik, MGC:31320

Feature Type

protein coding gene

Genetic Map

Chromosome 8

34.15 cM, cytoband B3-C1
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr8:70723720-70751186 bp, + strand From VEGA annotation of GRCm38   27467 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

Protein SuperFamily: 3',5'-cyclic-nucleotide phosphodiesterase 1B, calmodulin-dependent
Gene Tree: Pde4c

Human homologs

Human Homolog		PDE4C, phosphodiesterase 4C, cAMP-specific
NCBI Gene ID		5143
neXtProt AC		NX_Q08493
Human Synonyms		DPDE1
Human Chr (Location)		19p13.11; chr19:18318771-18359010 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cAMP catabolic process, negative regulation of insulin secretion, ...
Component	cell projection, cilium, ...
Function	3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(1) cDNA(16)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000027334 (Evidence)
Ensembl Gene Model	ENSMUSG00000031842 (Evidence)
Entrez Gene	110385 (Evidence)
UniGene	255180
DoTS	DT.40165368, DT.40166043
NIA Mouse Gene Index	U009441
EC	3.1.4.17
Consensus CDS Project	CCDS22378.1
International Mouse Knockout Project Status	Pde4c

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027334	VEGA Gene Model | MGI Sequence Detail	27467	C57BL/6J
transcript	OTTMUST00000067570	VEGA | MGI Sequence Detail	3290	Not Applicable
polypeptide	OTTMUSP00000034022	VEGA | MGI Sequence Detail	686	Not Applicable

All sequences(30) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(134 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023088	3'5'-cyclic nucleotide phosphodiesterase
InterPro	IPR002073	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro	IPR023174	3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro	IPR003607	HD/PDEase domain
Protein Ontology	PR:000012474	cAMP-specific 3',5'-cyclic phosphodiesterase 4C

References

(Earliest) J:18405 Milatovich A, et al., Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. Somat Cell Mol Genet. 1994 Mar;20(2):75-86
(Latest) J:173554 Choi YH, et al., Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10679-84
All references(36)

Other accession IDs

MGD-MRK-16334, MGI:3036271