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Pde4c
Gene Detail
Symbol

Name
ID
Pde4c
phosphodiesterase 4C, cAMP specific
MGI:99556
Synonyms
Dpde1, dunce, E130301F19Rik, MGC:31320
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.15 cM, cytoband B3-C1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:70723720-70751186 bp, + strand
From VEGA annotation of GRCm38

  27467 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20256  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

HCOP human homology predictions: PDE4C
Protein SuperFamily: 3',5'-cyclic-nucleotide phosphodiesterase 1B, calmodulin-dependent
Gene Tree: Pde4c

Human
homologs
PDE4C, phosphodiesterase 4C, cAMP-specific
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5143
neXtProt AC: NX_Q08493

Human Synonyms: DPDE1

Human Chr (Location): 19p13.11; chr19:18207961-18248200 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix )
Interactions
Pde4c interacts with 118 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pde4c ; ZFIN crtc1b, pde4ca    NEW 
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(16)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000027334 (Evidence)
Ensembl Gene Model ENSMUSG00000031842 (Evidence)
Entrez Gene 110385 (Evidence)
UniGene 255180
DoTS DT.40165368, DT.40166043
NIA Mouse Gene Index U009441
EC 3.1.4.53
Consensus CDS Project CCDS22378.1
International Mouse Phenotyping Consortium Status Pde4c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027334 VEGA Gene Model | MGI Sequence Detail 27467 C57BL/6J ±  kb
transcript OTTMUST00000067570 VEGA | MGI Sequence Detail 3290 Not Applicable 
polypeptide OTTMUSP00000034022 VEGA | MGI Sequence Detail 686 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(30) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(284 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR003607 HD/PDEase domain
Protein Ontology PR:000012474 cAMP-specific 3',5'-cyclic phosphodiesterase 4C
References
(Earliest) J:18405 Milatovich A, et al., Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. Somat Cell Mol Genet. 1994 Mar;20(2):75-86
(Latest) J:200285 Tian G, et al., Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion. J Cell Sci. 2012 Nov 1;125(Pt 21):5084-95
All references(36)
Other
accession IDs
MGD-MRK-16334, MGI:3036271

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory