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Lgals3bp
Gene Detail
 Symbol
Name
ID
Lgals3bp
lectin, galactoside-binding, soluble, 3 binding protein
MGI:99554
Synonyms 90K, CyCAP, MAC-2BP, Ppicap, Tango10b
Feature Type protein coding gene
Genetic Map
Chromosome 11
83.14 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:118392751-118402092 bp, - strand
From VEGA annotation of GRCm38

  9342 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4067  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 3 zebrafish

Gene Tree: Lgals3bp

Human
homologs
Human Homolog LGALS3BP, lectin, galactoside-binding, soluble, 3 binding protein
NCBI Gene ID 3959
neXtProt AC  NX_Q08380
Human Synonyms  90K, BTBD17B, CyCAP, gp90, M2BP, MAC-2-BP, TANGO10B
Human Chr (Location)  17q25; chr17:78971253-78979979 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants are more susceptible to bacterial infection and overproduce IL-12, interferon-gamma and TNF-alpha.
 
Interactions
Lgals3bp interacts with 42 markers (Mir17, Mir20b, Mir106a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell adhesion, receptor-mediated endocytosis
Component blood microparticle, extracellular matrix, ...
Function protein binding, scavenger receptor activity
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (193)    Tissues (58)    Images (48)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 147
RT-PCR 46
cDNA source data(209)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(211) Genomic(1) cDNA(209) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000003881 (Evidence)
Ensembl Gene ModelENSMUSG00000033880 (Evidence)
Entrez Gene19039 (Evidence)
UniGene3152
DFCITC1572065, TC1727017
DoTSDT.494404
NIA Mouse Gene IndexU033683
Consensus CDS ProjectCCDS25701.1
International Mouse Knockout Project StatusLgals3bp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003881 VEGA Gene Model | MGI Sequence Detail 9342 C57BL/6J ±  kb
transcript OTTMUST00000008559 VEGA | MGI Sequence Detail 2330 Not Applicable 
polypeptide OTTMUSP00000004164 VEGA | MGI Sequence Detail 577 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011705 BTB/Kelch-associated
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR001190 Speract/scavenger receptor
InterPro IPR017448 Speract/scavenger receptor-related
Protein Ontology PR:000009772 galectin-3-binding protein
References (Earliest) J:17545 Friedman J, et al., Cloning and characterization of cyclophilin C-associated protein: a candidate natural cellular ligand for cyclophilin C. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6815-9
(Latest) J:199909 Im SK, et al., Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice. PLoS One. 2013;8(3):e58511
All references(41)
Other
accession IDs
MGD-MRK-16332

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory