Gzmm
Gene Detail

Symbol Name ID

Gzmm granzyme M (lymphocyte met-ase 1) MGI:99549

Synonyms

Lmet1

Feature Type

protein coding gene

Genetic Map

Chromosome 10

39.72 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr10:79689020-79695261 bp, + strand From VEGA annotation of GRCm38   6242 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21099  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken

Protein SuperFamily: trypsin
Gene Tree: Gzmm

Human homologs

Human Homolog		GZMM, granzyme M (lymphocyte met-ase 1)
NCBI Gene ID		3004
neXtProt AC		NX_P51124
Human Synonyms		LMET1, MET1
Human Chr (Location)		19p13.3; chr19:544034-549920 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a knock-in allele display normal immune homeostasis, normal NK cell cytotoxicity and a normal response to ectromelia virus infection, but show a transient but significant increase in susceptibility to infection with the murine cytomegalovirus.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	cytolysis, metabolic process, ...
Function	endopeptidase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(6)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(8) cDNA(6)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000027871 (Evidence)
Ensembl Gene Model	ENSMUSG00000054206 (Evidence)
Entrez Gene	16904 (Evidence)
UniGene	378960
DFCI	TC1589074, TC1595896
DoTS	DT.527626, DT.87040789
NIA Mouse Gene Index	U322492
Consensus CDS Project	CCDS23984.1
International Mouse Knockout Project Status	Gzmm

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027871	VEGA Gene Model | MGI Sequence Detail	6242	C57BL/6J
transcript	OTTMUST00000069005	VEGA | MGI Sequence Detail	1287	Not Applicable
polypeptide	OTTMUSP00000035000	VEGA | MGI Sequence Detail	264	Not Applicable

All sequences(28) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(77 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001254	Peptidase S1
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR018114	Peptidase S1, trypsin family, active site
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000003481	granzyme M

References

(Earliest) J:22325 Pilat D, et al., The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3. Genomics. 1994 Dec;24(3):445-50
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(32)

Other accession IDs

MGD-MRK-16327