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Gzmm Gene Detail
Summary
  • Symbol
    Gzmm
  • Name
    granzyme M (lymphocyte met-ase 1)
  • Synonyms
    Lmet1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99549
    NCBI Gene: 16904
  • Gene Overview
    MyGene.info: GZMM
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79689020-79695261 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99549
protein coding gene Chr10:79689020-79695261 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017453
protein coding gene Chr10:80227712-80236060 (+)
A/J MGP_AJ_G0017431
protein coding gene Chr10:77439774-77445838 (+)
AKR/J MGP_AKRJ_G0017392
protein coding gene Chr10:79544431-79552412 (+)
BALB/cJ MGP_BALBcJ_G0017393
protein coding gene Chr10:77667830-77674059 (+)
C3H/HeJ MGP_C3HHeJ_G0017216
protein coding gene Chr10:79652312-79660464 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017847
protein coding gene Chr10:83000046-83008884 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015535
protein coding gene Chr10:73668185-73674235 (+)
CAST/EiJ MGP_CASTEiJ_G0016783
protein coding gene Chr10:79829425-79835879 (+)
CBA/J MGP_CBAJ_G0017188
protein coding gene Chr10:86224973-86231213 (+)
DBA/2J MGP_DBA2J_G0017294
protein coding gene Chr10:76657419-76663891 (+)
FVB/NJ MGP_FVBNJ_G0017288
protein coding gene Chr10:75818218-75825055 (+)
LP/J MGP_LPJ_G0017365
protein coding gene Chr10:80709938-80717058 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017314
protein coding gene Chr10:88204684-88210925 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017888
protein coding gene Chr10:79525201-79531277 (+)
PWK/PhJ MGP_PWKPhJ_G0016564
protein coding gene Chr10:76514939-76521357 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016353
protein coding gene Chr10:78498911-78505177 (+)
WSB/EiJ MGP_WSBEiJ_G0016843
protein coding gene Chr10:79554935-79562635 (+)



Homology
more
  • Human Ortholog
    GZMM, granzyme M
  • Vertebrate Orthologs
    6
  • Human Ortholog
    GZMM, granzyme M
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LMET1, MET1
  • Links
    NCBI Gene ID: 3004
    neXtProt AC: NX_P51124
    UniProt: P51124

  • Chr Location
    19p13.3; chr19:544034-549920 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele display normal immune homeostasis, normal NK cell cytotoxicity and a normal response to ectromelia virus infection, but show a transient but significant increase in susceptibility to infection with the murine cytomegalovirus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16904 NCBI Gene Model | MGI Sequence Detail 6242 C57BL/6J ±  kb
transcript NM_008504 RefSeq | MGI Sequence Detail 1304 C57BL/6  
polypeptide NP_032530 RefSeq | MGI Sequence Detail 264 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR033040 Granzyme M
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
less
  • All nucleic 14
    Genomic 8
    cDNA 6

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16327
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:208773 Afshar-Sterle S, et al., Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas. Nat Med. 2014 Mar;20(3):283-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory