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Gzmm
Gene Detail
Symbol

Name
ID
Gzmm
granzyme M (lymphocyte met-ase 1)
MGI:99549
Synonyms
Lmet1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:79689020-79695261 bp, + strand
From VEGA annotation of GRCm38

  6242 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21099  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken

Protein SuperFamily: trypsin
Gene Tree: Gzmm

Human
homologs
Human Homolog GZMM, granzyme M (lymphocyte met-ase 1)
NCBI Gene ID 3004
neXtProt AC  NX_P51124
Human Synonyms  LMET1, MET1
Human Chr (Location)  19p13.3; chr19:544034-549920 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele display normal immune homeostasis, normal NK cell cytotoxicity and a normal response to ectromelia virus infection, but show a transient but significant increase in susceptibility to infection with the murine cytomegalovirus.
 
Interactions
Gzmm interacts with 13 markers (Mir133a-1, Mir133a-2, Mir133b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process cytolysis, proteolysis
Component membrane
Function endopeptidase activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(6)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(8) cDNA(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027871 (Evidence)
Ensembl Gene ModelENSMUSG00000054206 (Evidence)
Entrez Gene16904 (Evidence)
UniGene378960
DFCITC1589074, TC1595896
DoTSDT.527626, DT.87040789
NIA Mouse Gene IndexU322492
Consensus CDS ProjectCCDS23984.1
International Mouse Knockout Project StatusGzmm
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027871 VEGA Gene Model | MGI Sequence Detail 6242 C57BL/6J ±  kb
transcript OTTMUST00000069005 VEGA | MGI Sequence Detail 1287 Not Applicable 
polypeptide OTTMUSP00000035000 VEGA | MGI Sequence Detail 264 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(10) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000003481 granzyme M
References
(Earliest) J:22325 Pilat D, et al., The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3. Genomics. 1994 Dec;24(3):445-50
(Latest) J:208773 Afshar-Sterle S, et al., Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas. Nat Med. 2014 Mar;20(3):283-90
All references(33)
Other
accession IDs
MGD-MRK-16327

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory