About   Help   FAQ
Usf1
Gene Detail
 Symbol
Name
ID
Usf1
upstream transcription factor 1
MGI:99542
Synonyms bHLHb11, upstream stimulatory factor
Feature Type protein coding gene
Genetic Map
Chromosome 1
79.40 cM, cytoband H
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr1:171411313-171419142 bp, + strand
From VEGA annotation of GRCm38

  7830 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31426  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: upstream stimulatory factor
Gene Tree: Usf1

Human
homologs
Human Homolog USF1, upstream transcription factor 1
NCBI Gene ID 7391
neXtProt AC  NX_P22415
Human Synonyms  bHLHb11, FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF
Human Chr (Location)  1q22-q23; chr1:161039251-161045979 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human USF1
Mutations,
alleles, and
phenotypes
All mutations/alleles(125) : Gene trapped(121) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants exhibit slight behavioral abnormalities. Females exhibit barbering and some have seizures. This knockout mutation (heterozygous or homozygous) acts as an enhancer of a null mutation of Usf2, resulting in embryonic lethality.
 
Interactions
Usf1 interacts with 136 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cellular response to insulin stimulus, glucose metabolic process, ...
Component nucleus, transcription factor complex
Function bHLH transcription factor binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (264)    Tissues (137)    Images (31)
Theiler Stages: 2, 3, 4, 5, 17, 19, 21, 23, 25, 27, 28
Assay TypeResults
RNA in situ 253
RT-PCR 11
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) Genomic(4) cDNA(37) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000030990 (Evidence)
Ensembl Gene ModelENSMUSG00000026641 (Evidence)
Entrez Gene22278 (Evidence)
UniGene8
DFCITC1582260, TC1588150, TC1640299
NIA Mouse Gene IndexU001088, U047116
Consensus CDS ProjectCCDS15495.1
International Mouse Knockout Project StatusUsf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030990 VEGA Gene Model | MGI Sequence Detail 7830 C57BL/6J ±  kb
transcript OTTMUST00000076757 VEGA | MGI Sequence Detail 2167 Not Applicable 
polypeptide OTTMUSP00000040457 VEGA | MGI Sequence Detail 310 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(8) UniProt(7)
Polymorphisms RFLP(2) : SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000017137 upstream stimulatory factor 1
References (Earliest) J:17048 Sirito M, et al., Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells. Nucleic Acids Res. 1994 Feb 11;22(3):427-33
(Latest) J:199076 Deng C, et al., USF1 and hSET1A mediated epigenetic modifications regulate lineage differentiation and HoxB4 transcription. PLoS Genet. 2013 Jun;9(6):e1003524
All references(74)
Other
accession IDs
MGD-MRK-16320

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory