Usf1
Gene Detail

Symbol Name ID

Usf1 upstream transcription factor 1 MGI:99542

Synonyms

bHLHb11, upstream stimulatory factor

Feature Type

protein coding gene

Genetic Map

Chromosome 1

79.40 cM, cytoband H
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr1:171411313-171419142 bp, + strand From VEGA annotation of GRCm38   7830 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31426  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: upstream stimulatory factor
Gene Tree: Usf1

Human homologs

Human Homolog		USF1, upstream transcription factor 1
NCBI Gene ID		7391
neXtProt AC		NX_P22415
Human Synonyms		bHLHb11, FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF
Human Chr (Location)		1q22-q23; chr1:161009041-161015757 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human USF1

Alleles and phenotypes

All alleles(125) : Targeted(4) Gene trapped(121)
 

Homozygous null mutants exhibit slight behavioral abnormalities. Females exhibit barbering and some have seizures. This knockout mutation (heterozygous or homozygous) acts as an enhancer of a null mutation of Usf2, resulting in embryonic lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	cellular response to insulin stimulus, glucose metabolic process, ...
Component	nucleus, transcription factor complex
Function	bHLH transcription factor binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (271)    Tissues (142)    Images (31)
Theiler Stages: 2, 3, 4, 5, 17, 19, 21, 23, 25, 28

Assay Type	Results
RNA in situ	253
RT-PCR	18

cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(46) Genomic(4) cDNA(37) Primer pair(4) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000030990 (Evidence)
Ensembl Gene Model	ENSMUSG00000026641 (Evidence)
Entrez Gene	22278 (Evidence)
UniGene	8
DFCI	TC1582260, TC1588150, TC1640299
NIA Mouse Gene Index	U001088, U047116
Consensus CDS Project	CCDS15495.1
International Mouse Knockout Project Status	Usf1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030990	VEGA Gene Model | MGI Sequence Detail	7830	C57BL/6J
transcript	OTTMUST00000076757	VEGA | MGI Sequence Detail	2167	Not Applicable
polypeptide	OTTMUSP00000040457	VEGA | MGI Sequence Detail	310	Not Applicable

All sequences(52) RefSeq(2) UniProt(7)

Polymorphisms

RFLP(2) : SNPs(81 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Helix-loop-helix domain
Protein Ontology	PR:000017137	upstream stimulatory factor 1

References

(Earliest) J:17048 Sirito M, et al., Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells. Nucleic Acids Res. 1994 Feb 11;22(3):427-33
(Latest) J:188151 Repetto E, et al., Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP. PLoS Genet. 2012 Jul;8(7):e1002823
All references(70)

Other accession IDs

MGD-MRK-16320