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Ptgir
Gene Detail
 Symbol
Name
ID
Ptgir
prostaglandin I receptor (IP)
MGI:99535
Synonyms IP, prostacyclin receptor
Feature Type protein coding gene
Genetic Map
Chromosome 7
9.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:16906490-16910905 bp, + strand
From VEGA annotation of GRCm38

  4416 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7496  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-coupled prostanoid receptor
Gene Tree: Ptgir

Human
homologs
Human Homolog PTGIR, prostaglandin I2 (prostacyclin) receptor (IP)
NCBI Gene ID 5739
neXtProt AC  NX_P43119
Human Synonyms  IP, PRIPR
Human Chr (Location)  19q13.3; chr19:46611328-46625118 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix )
 
Homozygotes for a targeted null mutation exhibit increased susceptibility to thrombosis and injury-induced vascular proliferation, and decreased inflammatory and pain responses.
 
Interactions
Ptgir interacts with 195 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process adenylate cyclase-activating G-protein coupled receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component cytosol, integral component of membrane, ...
Function G-protein coupled receptor activity, signal transducer activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (92)    Tissues (45)    Images (2)
Theiler Stages: 23, 28
Assay TypeResults
RT-PCR 92
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(9) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033384 (Evidence)
Ensembl Gene ModelENSMUSG00000043017 (Evidence)
Entrez Gene19222 (Evidence)
UniGene287572
DFCITC1582041, TC1595142
DoTSDT.40140614, DT.94277190
NIA Mouse Gene IndexU007721
PDB4F8K
Consensus CDS ProjectCCDS20857.2
International Mouse Knockout Project StatusPtgir
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033384 VEGA Gene Model | MGI Sequence Detail 4416 C57BL/6J ±  kb
transcript OTTMUST00000083811 VEGA | MGI Sequence Detail 3305 Not Applicable 
polypeptide OTTMUSP00000045084 VEGA | MGI Sequence Detail 415 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000370 Prostacyclin (prostanoid IP) receptor
InterPro IPR008365 Prostanoid receptor
Protein Ontology PR:000001655 prostacyclin receptor
References (Earliest) J:17520 Namba T, et al., cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla. J Biol Chem. 1994 Apr 1;269(13):9986-92
(Latest) J:201852 Toki S, et al., PGI(2) signaling inhibits antigen uptake and increases migration of immature dendritic cells. J Leukoc Biol. 2013 Jul;94(1):77-88
All references(72)
Other
accession IDs
MGD-MRK-16313

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory