Ptgir
Gene Detail

Symbol Name ID

Ptgir prostaglandin I receptor (IP) MGI:99535

Synonyms

IP, prostacyclin receptor

Feature Type

protein coding gene

Genetic Map

Chromosome 7

9.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:16906490-16910905 bp, + strand From VEGA annotation of GRCm38   4416 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7496  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: G protein-coupled prostanoid receptor
Gene Tree: Ptgir

Human homologs

Human Homolog		PTGIR, prostaglandin I2 (prostacyclin) receptor (IP)
NCBI Gene ID		5739
neXtProt AC		NX_P43119
Human Synonyms		IP, PRIPR
Human Chr (Location)		19q13.3; chr19:47123725-47128354 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygotes for a targeted null mutation exhibit increased susceptibility to thrombosis and injury-induced vascular proliferation, and decreased inflammatory and pain responses.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	adenylate cyclase-activating G-protein coupled receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component	cytosol, integral to membrane, ...
Function	G-protein coupled receptor activity, signal transducer activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (92)    Tissues (45)    Images (2)
Theiler Stages: 23, 28

Assay Type	Results
RT-PCR	92

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) Genomic(1) cDNA(9) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000033384 (Evidence)
Ensembl Gene Model	ENSMUSG00000043017 (Evidence)
Entrez Gene	19222 (Evidence)
UniGene	287572
DFCI	TC1582041, TC1595142
DoTS	DT.40140614, DT.94277190
NIA Mouse Gene Index	U007721
Consensus CDS Project	CCDS20857.2
International Mouse Knockout Project Status	Ptgir

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033384	VEGA Gene Model | MGI Sequence Detail	4416	C57BL/6J
transcript	OTTMUST00000083811	VEGA | MGI Sequence Detail	3305	Not Applicable
polypeptide	OTTMUSP00000045084	VEGA | MGI Sequence Detail	415	Not Applicable

All sequences(29) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(42 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
InterPro	IPR000370	Prostacyclin (prostanoid IP) receptor
InterPro	IPR008365	Prostanoid receptor
Protein Ontology	PR:000001655	prostacyclin receptor

References

(Earliest) J:17520 Namba T, et al., cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla. J Biol Chem. 1994 Apr 1;269(13):9986-92
(Latest) J:189580 Guo Y, et al., The COX-2/PGI2 receptor axis plays an obligatory role in mediating the cardioprotection conferred by the late phase of ischemic preconditioning. PLoS One. 2012;7(7):e41178
All references(70)

Other accession IDs

MGD-MRK-16313