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Cd63 Gene Detail
Summary
  • Symbol
    Cd63
  • Name
    CD63 antigen
  • Synonyms
    ME491, Tspan30
  • Feature Type
    protein coding gene
  • IDs
    MGI:99529
    NCBI Gene: 12512
  • Gene Overview
    MyGene.info: CD63
Location & Maps
more
  • Sequence Map
    Chr10:128908919-128912816 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      3898 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 77.19 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CD63, CD63 molecule
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CD63, CD63 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LAMP-3, ME491, MLA1, OMA81H, TSPAN30
  • Links
    NCBI Gene ID: 967
    neXtProt AC: NX_P08962

  • Chr Location
    12q13.2; chr12:55725443-55729673 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    30
  • Gene trapped
    24
  • Targeted
    6
Homozygous null mice are viable and fertile without gross morphological abnormalities, but show an altered water balance, indicated by an increased urinary flow, water intake, reduced urine osmolality, and a higher fecal water content.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    47
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    14
  • Tissues
    11
  • cDNA Data
    24
  • Literature Summary
    5
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025351 Ensembl Gene Model | MGI Sequence Detail 3898 C57BL/6J ±  kb
transcript ENSMUST00000105229 Ensembl | MGI Sequence Detail 938 Not Applicable  
polypeptide ENSMUSP00000100862 Ensembl | MGI Sequence Detail 238 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    40 from dbSNP Build 142
  • RFLP
    1
Protein
Information
less
Molecular
Reagents
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  • All nucleic 26
    cDNA 26

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-16307, MGI:2147391
References
more
  • Summaries
    All 60
    Developmental Gene Expression 5
    Gene Ontology 12
    Phenotypes 13
  • Earliest
    J:17595 Miyamoto H, et al., Molecular cloning of the murine homologue of CD63/ME491 and detection of its strong expression in the kidney and activated macrophages. Biochim Biophys Acta. 1994 Apr 6;1217(3):312-6
  • Latest
    J:205899 Kraft S, et al., The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis. J Immunol. 2013 Sep 15;191(6):2871-8
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory