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Cd63 Gene Detail
Summary
  • Symbol
    Cd63
  • Name
    CD63 antigen
  • Synonyms
    ME491, Tspan30
  • Feature Type
    protein coding gene
  • IDs
    MGI:99529
    NCBI Gene: 12512
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128736858-128748691 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 77.19 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    101 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99529
protein coding gene Chr10:128731577-128748691 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017888
protein coding gene Chr10:132707886-132713826 (+)
A/J MGP_AJ_G0017863
protein coding gene Chr10:127365803-127369699 (+)
AKR/J MGP_AKRJ_G0017826
protein coding gene Chr10:131081510-131085405 (+)
BALB/cJ MGP_BALBcJ_G0017827
protein coding gene Chr10:127725676-127729571 (+)
C3H/HeJ MGP_C3HHeJ_G0017650
protein coding gene Chr10:131258038-131261933 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018282
protein coding gene Chr10:137182098-137185993 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015960
protein coding gene Chr10:121273104-121276843 (+)
CAST/EiJ MGP_CASTEiJ_G0017211
protein coding gene Chr10:131984081-131989316 (+)
CBA/J MGP_CBAJ_G0017620
protein coding gene Chr10:142779621-142783517 (+)
DBA/2J MGP_DBA2J_G0017726
protein coding gene Chr10:126422938-126426834 (+)
FVB/NJ MGP_FVBNJ_G0017721
protein coding gene Chr10:125343967-125347980 (+)
LP/J MGP_LPJ_G0017800
protein coding gene Chr10:133286994-133290910 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017749
protein coding gene Chr10:145334928-145338831 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018322
protein coding gene Chr10:131191338-131195233 (+)
PWK/PhJ MGP_PWKPhJ_G0016996
protein coding gene Chr10:126691803-126695966 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016785
protein coding gene Chr10:130306489-130311476 (+)
WSB/EiJ MGP_WSBEiJ_G0017270
protein coding gene Chr10:131423580-131427458 (+)



Homology
more
  • Human Ortholog
    CD63, CD63 molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD63, CD63 molecule
  • Synonyms
    AD1, HOP-26, ME491, MLA1, OMA81H, Pltgp40, TSPAN30
  • Links
    NCBI Gene ID: 967
    neXtProt AC: NX_P08962
    UniProt: P08962

  • Chr Location
    12q13.2; chr12:55723535-55730041 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile without gross morphological abnormalities, but show an altered water balance, indicated by an increased urinary flow, water intake, reduced urine osmolality, and a higher fecal water content.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025351 Ensembl Gene Model | MGI Sequence Detail 11834 C57BL/6J ±  kb
    transcript ENSMUST00000105229 Ensembl | MGI Sequence Detail 1043 Not Applicable  
    polypeptide ENSMUSP00000100862 Ensembl | MGI Sequence Detail 238 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 27

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-16307, MGI:2147391
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 8
      Gene Ontology 13
      Phenotypes 21
    • Earliest
      J:43903 Hotta H, et al., Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression. Cancer Res. 1988 Jun 1;48(11):2955-62
    • Latest
      J:340884 De Silva NS, et al., Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages. Nat Aging. 2023 Sep 18;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory