Cd63 MGI Mouse Gene Detail - MGI:99529

Symbol

Cd63
Name

CD63 antigen
Synonyms

ME491, Tspan30

Feature Type

protein coding gene
IDs

MGI:99529
NCBI Gene: 12512
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr10:128736858-128748691 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 77.19 cM
Mapping Data

3 experiments

SNPs within 2kb

432 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99529	protein coding gene	Chr10:128731577-128748691 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017888	protein coding gene	Chr10:132707886-132713826 (+)
A/J	MGP_AJ_G0017863	protein coding gene	Chr10:127365803-127369699 (+)
AKR/J	MGP_AKRJ_G0017826	protein coding gene	Chr10:131081510-131085405 (+)
BALB/cJ	MGP_BALBcJ_G0017827	protein coding gene	Chr10:127725676-127729571 (+)
C3H/HeJ	MGP_C3HHeJ_G0017650	protein coding gene	Chr10:131258038-131261933 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018282	protein coding gene	Chr10:137182098-137185993 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015960	protein coding gene	Chr10:121273104-121276843 (+)
CAST/EiJ	MGP_CASTEiJ_G0017211	protein coding gene	Chr10:131984081-131989316 (+)
CBA/J	MGP_CBAJ_G0017620	protein coding gene	Chr10:142779621-142783517 (+)
DBA/2J	MGP_DBA2J_G0017726	protein coding gene	Chr10:126422938-126426834 (+)
FVB/NJ	MGP_FVBNJ_G0017721	protein coding gene	Chr10:125343967-125347980 (+)
LP/J	MGP_LPJ_G0017800	protein coding gene	Chr10:133286994-133290910 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017749	protein coding gene	Chr10:145334928-145338831 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018322	protein coding gene	Chr10:131191338-131195233 (+)
PWK/PhJ	MGP_PWKPhJ_G0016996	protein coding gene	Chr10:126691803-126695966 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016785	protein coding gene	Chr10:130306489-130311476 (+)
WSB/EiJ	MGP_WSBEiJ_G0017270	protein coding gene	Chr10:131423580-131427458 (+)

Human Ortholog

CD63, CD63 molecule

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD63, CD63 molecule
Synonyms

AD1, HOP-26, ME491, MLA1, OMA81H, Pltgp40, TSPAN30
Links

HGNC:1692

NCBI Gene ID: 967

UniProt: P08962
Chr Location

12q13.2; chr12:55723535-55730041 (-) GRCh38

MGI Vertebrate Homology

Cd63 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CD63
Protein SuperFamily

Tetraspanin
Gene Tree

Cd63

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

37
Endonuclease-mediated

7
Gene trapped

24
Targeted

6
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are viable and fertile without gross morphological abnormalities, but show an altered water balance, indicated by an increased urinary flow, water intake, reduced urine osmolality, and a higher fecal water content.

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All GO Annotations

90
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

17
cDNA Data

25
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cd63

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All Sequences

91
RefSeq

16
UniProt

5
CCDS

CCDS24297.1

Ensembl

ENSMUSG00000025351 (Evidence)
NCBI Gene

12512

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025351	Ensembl Gene Model \| MGI Sequence Detail	11834	C57BL/6J	± kb
transcript	ENSMUST00000026407	Ensembl \| MGI Sequence Detail	1063	Not Applicable
polypeptide	ENSMUSP00000026407	Ensembl \| MGI Sequence Detail	238	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005175 CD63 molecule

(term hierarchy)
InterPro Domains

IPR042028 CD63, extracellular domain

IPR000301 Tetraspanin, animals

IPR018503 Tetraspanin, conserved site

IPR008952 Tetraspanin, EC2 domain superfamily

IPR018499 Tetraspanin/Peripherin
GlyGen

P41731 4 sites, 3 N-linked glycans (3 sites)

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All nucleic 27

cDNA 27

Microarray probesets 2

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MGD-MRK-16307, MGI:2147391

Summaries

All 85

Developmental Gene Expression 8

Gene Ontology 17

Phenotypes 23
Earliest

J:43903 Hotta H, et al., Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression. Cancer Res. 1988 Jun 1;48(11):2955-62
Latest

J:353856 Chang H, et al., Stress-sensitive neural circuits change the gut microbiome via duodenal glands. Cell. 2024 Aug 1;

TSS for Cd63:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96467	Chr10:128736198-128736230 (+)	-644 bp
Tssr96468	Chr10:128736833-128736844 (+)	-19 bp
Tssr96469	Chr10:128744776-128744794 (+)	7,927 bp
Tssr96470	Chr10:128744835-128744847 (+)	7,983 bp
Tssr96471	Chr10:128744865-128744896 (+)	8,023 bp
Tssr96472	Chr10:128745273-128745298 (+)	8,428 bp
Tssr96473	Chr10:128745299-128745312 (+)	8,448 bp
Tssr96474	Chr10:128745498-128745505 (+)	8,644 bp
Tssr96475	Chr10:128745738-128745742 (+)	8,882 bp
Tssr96476	Chr10:128745764-128745799 (+)	8,924 bp
Tssr96477	Chr10:128747342-128747387 (+)	10,507 bp
Tssr96478	Chr10:128747438-128747467 (+)	10,595 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24