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Tnr Gene Detail
Summary
  • Symbol
    Tnr
  • Name
    tenascin R
  • Synonyms
    J1-tenascin, janusin, restrictin, TN-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:99516
    NCBI Gene: 21960
  • Gene Overview
    MyGene.info: TNR
Location & Maps
more
  • Sequence Map
    Chr1:159523769-159931729 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      407961 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TNR, tenascin R
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TNR, tenascin R
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TN-R
  • Links
    NCBI Gene ID: 7143
    neXtProt AC: NX_Q92752

  • Chr Location
    1q24; chr1:175322799-175743702 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 124416
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TNR
  • Gene Tree
    Tnr
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Tnr
  • Incidental Mutations
In spite of having decreased conduction velocity in the optic nerve and ultrastrucural alterations within the hippocampus, homozygous null mice are viable, fertile, and display normal behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050612 VEGA Gene Model | MGI Sequence Detail 407961 C57BL/6J ±  kb
transcript OTTMUST00000128324 VEGA | MGI Sequence Detail 12202 Not Applicable  
polypeptide OTTMUSP00000069048 VEGA | MGI Sequence Detail 1358 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    4025 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016516 tenascin-R
  • InterPro Domains
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
    IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
    IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
    IPR033079 Tenascin-R
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-16293
References
more
  • Summaries
    All 57
    Developmental Gene Expression 5
    Gene Ontology 20
    Phenotypes 29
  • Earliest
    J:33496 Akhurst RJ, et al., TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis. Development. 1990 Apr;108(4):645-56
  • Latest
    J:212357 Xu JC, et al., The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice. J Cell Sci. 2014 Feb 1;127(Pt 3):641-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory