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Sdpr Gene Detail
Summary
  • Symbol
    Sdpr
  • Name
    serum deprivation response
  • Synonyms
    cavin 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99513
    NCBI Gene: 20324
  • Gene Overview
    MyGene.info: SDPR
Location & Maps
more
  • Sequence Map
    Chr1:51289126-51302960 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13835 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 26.13 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SDPR, serum deprivation response
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SDPR, serum deprivation response
    Orthology source: HomoloGene, HGNC
  • Synonyms
    cavin-2, CAVIN2, PS-p68, SDR
  • Links
    NCBI Gene ID: 8436
    neXtProt AC: NX_O95810

  • Chr Location
    2q32.3; chr2:191834305-191847280 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3422
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: SDPR
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Sdpr
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a knock-out allele exhibit abnormal caveolae formation in lung and adipose endothelia and adipocytes with gaps in the lung capillaries.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046712 VEGA Gene Model | MGI Sequence Detail 13835 C57BL/6J ±  kb
transcript OTTMUST00000121323 VEGA | MGI Sequence Detail 3055 Not Applicable  
polypeptide OTTMUSP00000066894 VEGA | MGI Sequence Detail 418 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    57 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014569 serum deprivation-response protein
  • InterPro Domains
    IPR026752 Cavin family
    IPR033298 Serum deprivation-response protein
Molecular
Reagents
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  • All nucleic 78
    cDNA 76
    Primer pair 1
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-16290
References
more
  • Summaries
    All 28
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:16418 Gustincich S, et al., Serum deprivation response gene is induced by serum starvation but not by contact inhibition. Cell Growth Differ. 1993 Sep;4(9):753-60
  • Latest
    J:205741 Hansen CG, et al., Deletion of cavin genes reveals tissue-specific mechanisms for morphogenesis of endothelial caveolae. Nat Commun. 2013;4:1831

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory