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Tmsb4x Gene Detail
Summary
  • Symbol
    Tmsb4x
  • Name
    thymosin, beta 4, X chromosome
  • Synonyms
    Ptmb4, Tb4, Tbeta4
  • Feature Type
    protein coding gene
  • IDs
    MGI:99510
    NCBI Gene: 19241
  • Gene Overview
    MyGene.info: TMSB4X
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:167207093-167209315 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 78.28 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99510
protein coding gene ChrX:167207093-167213479 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036269
protein coding gene ChrX:165373722-165375943 (-)
A/J MGP_AJ_G0036238
protein coding gene ChrX:164522905-164525126 (-)
AKR/J MGP_AKRJ_G0036168
protein coding gene ChrX:169803900-169806121 (-)
BALB/cJ MGP_BALBcJ_G0036233
protein coding gene ChrX:162469464-162471685 (-)
C3H/HeJ MGP_C3HHeJ_G0035940
protein coding gene ChrX:165678486-165680707 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036756
protein coding gene ChrX:170173116-170176480 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033576
protein coding gene ChrX:155340147-155342387 (-)
CAST/EiJ MGP_CASTEiJ_G0035227
protein coding gene ChrX:144569964-144572186 (-)
CBA/J MGP_CBAJ_G0035914
protein coding gene ChrX:175143452-175145673 (-)
DBA/2J MGP_DBA2J_G0036080
protein coding gene ChrX:163327053-163329274 (-)
FVB/NJ MGP_FVBNJ_G0036012
protein coding gene ChrX:162461661-162463882 (-)
LP/J MGP_LPJ_G0036165
protein coding gene ChrX:166462011-166464232 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0036044
protein coding gene ChrX:183832426-183834645 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036795
protein coding gene ChrX:164836468-164838687 (-)
PWK/PhJ MGP_PWKPhJ_G0034926
protein coding gene ChrX:141303783-141306000 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034745
protein coding gene ChrX:145112769-145115009 (-)
WSB/EiJ MGP_WSBEiJ_G0035363
protein coding gene ChrX:162683492-162685711 (-)



Homology
more
  • Human Ortholog
    TMSB4X, thymosin beta 4 X-linked
  • Vertebrate Orthologs
    4
  • Human Ortholog
    TMSB4X, thymosin beta 4 X-linked
    Orthology source: HGNC
  • Synonyms
    FX, PTMB4, TB4X, TMSB4
  • Links
    NCBI Gene ID: 7114
    neXtProt AC: NX_P62328
    UniProt: P62328

  • Chr Location
    Xp22.2; chrX:12975107-12977227 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele are viable and fertile with no notable cardiovascular defects in adult mice. Mice homozygous for a different allele exhibit partial embryonic lethality due to vascular defects associated with impaired differentiationof mural cells from mesoderm in some mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049775 Ensembl Gene Model | MGI Sequence Detail 2223 C57BL/6J ±  kb
    transcript ENSMUST00000112176 Ensembl | MGI Sequence Detail 698 Not Applicable  
    polypeptide ENSMUSP00000107798 Ensembl | MGI Sequence Detail 50 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 2
      cDNA 18
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16287
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 32
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:17077 Rudin CM, et al., Differential splicing of thymosin beta 4 mRNA. J Immunol. 1990 Jun 15;144(12):4857-62
    • Latest
      J:271446 Sun M, et al., Crybb2 associates with Tmsb4X and is crucial for dendrite morphogenesis. Biochem Biophys Res Commun. 2018 Sep 3;503(1):123-130

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/18/2019
    MGI 6.14
    The Jackson Laboratory