Fgb
Gene Detail

Symbol Name ID

Fgb fibrinogen beta chain MGI:99501

Synonyms

2510049G14Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 3

36.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:83042303-83049790 bp, - strand From NCBI annotation of GRCm38   7488 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3772  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fgb

Human homologs

Human Homolog		FGB, fibrinogen beta chain
NCBI Gene ID		2244
neXtProt AC		NX_P02675
Human Chr (Location)		4q28; chr4:155484132-155493915 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FGB

Alleles and phenotypes

All alleles(1) : Targeted(1)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	blood coagulation, hemostasis, ...
Component	blood microparticle, cell cortex, ...
Function	chaperone binding, eukaryotic cell surface binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (56)    Tissues (20)    Images (36)
Theiler Stages: 12, 20, 22, 23, 24, 25

Assay Type	Results
Immunohistochemistry	30
RNA in situ	24
RT-PCR	2

cDNA source data(245)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(247) cDNA(245) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000033831 (Evidence)
Entrez Gene	110135 (Evidence)
UniGene	30063
DFCI	TC1571954
DoTS	DT.55169769
NIA Mouse Gene Index	U024198
Consensus CDS Project	CCDS17432.1
International Mouse Knockout Project Status	Fgb

Sequences

Length	Strain/Species
genomic	110135	NCBI Gene Model | MGI Sequence Detail	7488	C57BL/6J
transcript	NM_181849	RefSeq | MGI Sequence Detail	1575	C57BL/6
polypeptide	Q8K0E8	UniProt | EBI | MGI Sequence Detail	481	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(63 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012290	Fibrinogen, alpha/beta/gamma chain, coiled coil domain
InterPro	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro	IPR014715	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro	IPR020837	Fibrinogen, conserved site
Protein Ontology	PR:000007472	fibrinogen beta chain

Graphical View of Protein Domain Structure

References

(Earliest) J:24378 Mills KA, et al., Genetic mapping near the myd locus on mouse chromosome 8. Mamm Genome. 1995 Apr;6(4):278-80
(Latest) J:170493 Pfister S, et al., Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. Int J Dev Biol. 2011;55(1):45-58
All references(43)

Other accession IDs

MGD-MRK-16277, MGI:1915158