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Fgb
Gene Detail
Symbol

Name
ID
Fgb
fibrinogen beta chain
MGI:99501
Synonyms
2510049G14Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 3
36.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:83042303-83049790 bp, - strand
From NCBI annotation of GRCm38

  7488 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3772  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fgb

Human
homologs
Human Homolog FGB, fibrinogen beta chain
NCBI Gene ID 2244
neXtProt AC  NX_P02675
Human Synonyms  HEL-S-78p
Human Chr (Location)  4q28; chr4:154562980-154572763 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FGB
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Fgb interacts with 58 markers (Mir16-2, Mir27a, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process blood coagulation, cell-matrix adhesion, ...
Component blood microparticle, cell cortex, ...
Function cell adhesion molecule binding, chaperone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (56)    Tissues (20)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 30
RNA in situ 24
RT-PCR 2
cDNA source data(245)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(247) cDNA(245) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000033831 (Evidence)
Entrez Gene110135 (Evidence)
UniGene30063
DFCITC1571954
DoTSDT.55169769
NIA Mouse Gene IndexU024198
Consensus CDS ProjectCCDS17432.1
International Mouse Knockout Project StatusFgb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 110135 NCBI Gene Model | MGI Sequence Detail 7488 C57BL/6J ±  kb
transcript NM_181849 RefSeq | MGI Sequence Detail 1575 C57BL/6 
polypeptide Q8K0E8 UniProt | EBI | MGI Sequence Detail 481 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(85 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000007472 fibrinogen beta chain
Graphical View of Protein Domain Structure
References
(Earliest) J:24378 Mills KA, et al., Genetic mapping near the myd locus on mouse chromosome 8. Mamm Genome. 1995 Apr;6(4):278-80
(Latest) J:170493 Pfister S, et al., Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. Int J Dev Biol. 2011;55(1):45-58
All references(44)
Other
accession IDs
MGD-MRK-16277, MGI:1915158

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory