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Fgb
Gene Detail
Symbol

Name
ID
Fgb
fibrinogen beta chain
MGI:99501
Synonyms
2510049G14Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 3
36.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:83040141-83049863 bp, - strand
From VEGA annotation of GRCm38

  9723 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3772  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FGB
Gene Tree: Fgb

Human
homologs
FGB, fibrinogen beta chain
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2244
neXtProt AC: NX_P02675

Human Synonyms: HEL-S-78p

Human Chr (Location): 4q28; chr4:154562980-154572763 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human FGB

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Fgb interacts with 58 markers (Mir16-2, Mir27a, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process adaptive immune response, blood coagulation, ...
Component blood microparticle, cell cortex, ...
Function cell adhesion molecule binding, chaperone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (56)    Tissues (20)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 30
RNA in situ 24
RT-PCR 2
cDNA source data(245)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FGB ; Xenbase fgb ; ZFIN fgb    NEW 
Molecular
reagents
All nucleic(247) cDNA(245) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000051804 (Evidence)
Ensembl Gene Model ENSMUSG00000033831 (Evidence)
Entrez Gene 110135 (Evidence)
UniGene 30063
DFCI TC1571954
DoTS DT.55169769
NIA Mouse Gene Index U024198
Consensus CDS Project CCDS17432.1
International Mouse Phenotyping Consortium Status Fgb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051804 VEGA Gene Model | MGI Sequence Detail 9723 C57BL/6J ±  kb
transcript OTTMUST00000130537 VEGA | MGI Sequence Detail 3810 Not Applicable 
polypeptide OTTMUSP00000069935 VEGA | MGI Sequence Detail 481 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(97 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000007472 fibrinogen beta chain
References
(Earliest) J:24378 Mills KA, et al., Genetic mapping near the myd locus on mouse chromosome 8. Mamm Genome. 1995 Apr;6(4):278-80
(Latest) J:170493 Pfister S, et al., Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. Int J Dev Biol. 2011;55(1):45-58
All references(43)
Other
accession IDs
MGD-MRK-16277, MGI:1915158

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory