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Ephx2 Gene Detail
Summary
  • Symbol
    Ephx2
  • Name
    epoxide hydrolase 2, cytoplasmic
  • Synonyms
    Eph2, sEH, sEP
  • Feature Type
    protein coding gene
  • IDs
    MGI:99500
    NCBI Gene: 13850
  • Gene Overview
    MyGene.info: EPHX2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:66084374-66124500 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 34.36 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    191 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99500
protein coding gene Chr14:66084372-66124522 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021491
protein coding gene Chr14:60739213-60780074 (-)
A/J MGP_AJ_G0021450
protein coding gene Chr14:59310583-59350642 (-)
AKR/J MGP_AKRJ_G0021426
protein coding gene Chr14:61373029-61414532 (-)
BALB/cJ MGP_BALBcJ_G0021456
protein coding gene Chr14:59259971-59302122 (-)
C3H/HeJ MGP_C3HHeJ_G0021233
protein coding gene Chr14:61051975-61092263 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021895
protein coding gene Chr14:63530761-63574227 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019435
protein coding gene Chr14:57238734-57280526 (-)
CAST/EiJ MGP_CASTEiJ_G0020750
protein coding gene Chr14:57529050-57572415 (-)
CBA/J MGP_CBAJ_G0021200
protein coding gene Chr14:65468927-65510558 (-)
DBA/2J MGP_DBA2J_G0021323
protein coding gene Chr14:58957583-58997969 (-)
FVB/NJ MGP_FVBNJ_G0021302
protein coding gene Chr14:58367882-58408276 (-)
LP/J MGP_LPJ_G0021398
protein coding gene Chr14:61782555-61824697 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021331
protein coding gene Chr14:64534773-64577318 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021918
protein coding gene Chr14:60564481-60605291 (-)
PWK/PhJ MGP_PWKPhJ_G0020494
protein coding gene Chr14:55685157-55730992 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020327
protein coding gene Chr14:56533973-56575187 (-)
WSB/EiJ MGP_WSBEiJ_G0020803
protein coding gene Chr14:60871764-60914094 (-)



Homology
more
  • Human Ortholog
    EPHX2, epoxide hydrolase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EPHX2, epoxide hydrolase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABHD20, CEH, SEH
  • Links
    NCBI Gene ID: 2053
    neXtProt AC: NX_P34913
    UniProt: P34913

  • Chr Location
    8p21.2-p21.1; chr8:27491002-27597559 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37558
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EPHX2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human EPHX2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 4 genetic backgrounds
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Males homozygous for a targeted null mutation display a significant reduction in blood pressure both in the absence and presence of dietary salt loading. Both sexes exhibit altered arachidonic acid metabolism and reduced renal formation of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022040 Ensembl Gene Model | MGI Sequence Detail 40127 C57BL/6J ±  kb
    transcript ENSMUST00000070515 Ensembl | MGI Sequence Detail 2035 Not Applicable  
    polypeptide ENSMUSP00000069209 Ensembl | MGI Sequence Detail 554 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 134
      cDNA 134

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16276, MGI:2145794
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 56
    • Earliest
      J:7687 Simmons DL, et al., Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes. J Biol Chem. 1985 Jan 10;260(1):515-21
    • Latest
      J:274391 Ma M, et al., Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7083-7088

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/18/2019
    MGI 6.14
    The Jackson Laboratory