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Ephx2
Gene Detail
Symbol

Name
ID
Ephx2
epoxide hydrolase 2, cytoplasmic
MGI:99500
Synonyms
Eph2, sEH, sEP
Feature Type
protein coding gene
Genetic Map
Chromosome 14
34.36 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:66084377-66124500 bp, - strand
From Ensembl annotation of GRCm38

  40124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37558  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EPHX2
Gene Tree: Ephx2

Human
homologs
EPHX2, epoxide hydrolase 2, cytoplasmic
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2053
neXtProt AC: NX_P34913

Human Synonyms: CEH, SEH

Human Chr (Location): 8p21; chr8:27491002-27544922 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human EPHX2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Males homozygous for a targeted null mutation display a significant reduction in blood pressure both in the absence and presence of dietary salt loading. Both sexes exhibit altered arachidonic acid metabolism and reduced renal formation of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids.
 
Interactions
Ephx2 interacts with 64 markers (Mir124a-1, Mir124a-2, Mir124a-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process aromatic compound catabolic process, cholesterol homeostasis, ...
Component cytoplasm, cytosol, ...
Function 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (113)    Tissues (95)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 113
cDNA source data(133)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ephx2 ; ZFIN ephx2    NEW 
Molecular
reagents
All nucleic(133) cDNA(133)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000022040 (Evidence)
Entrez Gene 13850 (Evidence)
UniGene 15295
DFCI TC1746244, TC1575768
DoTS DT.101224048, DT.97365736, DT.55240878, DT.534872
NIA Mouse Gene Index U035700
EC 3.3.2.10, 3.1.3.76
PDB 1CQZ, 1CR6, 1EK1, 1EK2
Consensus CDS Project CCDS27218.1
International Mouse Phenotyping Consortium Status Ephx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022040 Ensembl Gene Model | MGI Sequence Detail 40124 C57BL/6J ±  kb
transcript ENSMUST00000070515 Ensembl | MGI Sequence Detail 2035 Not Applicable 
polypeptide ENSMUSP00000069209 Ensembl | MGI Sequence Detail 554 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(194 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000073 Alpha/beta hydrolase fold-1
InterPro IPR000639 Epoxide hydrolase-like
InterPro IPR023214 HAD-like domain
InterPro IPR006439 HAD-superfamily hydrolase, subfamily IA, variant 1
InterPro IPR023198 Phosphoglycolate phosphatase, domain 2
InterPro IPR011945 Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal
Protein Ontology PR:000007135 epoxide hydrolase 2
References
(Earliest) J:7687 Simmons DL, et al., Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes. J Biol Chem. 1985 Jan 10;260(1):515-21
(Latest) J:216186 Zha W, et al., Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity. J Lipid Res. 2014 Oct;55(10):2124-36
All references(80)
Other
accession IDs
MGD-MRK-16276, MGI:2145794

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory