Ephx2
Gene Detail

Symbol Name ID

Ephx2 epoxide hydrolase 2, cytoplasmic MGI:99500

Synonyms

Eph2, sEH, sEP

Feature Type

protein coding gene

Genetic Map

Chromosome 14

34.36 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr14:66084377-66124500 bp, - strand From NCBI annotation of GRCm38   40124 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37558  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ephx2

Human homologs

Human Homolog		EPHX2, epoxide hydrolase 2, cytoplasmic
NCBI Gene ID		2053
neXtProt AC		NX_P34913
Human Synonyms		CEH, SEH
Human Chr (Location)		8p21; chr8:27348519-27402439 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human EPHX2

Alleles and phenotypes

All alleles(6) : Targeted(3) Gene trapped(3)
 

Males homozygous for a targeted null mutation display a significant reduction in blood pressure both in the absence and presence of dietary salt loading. Both sexes exhibit altered arachidonic acid metabolism and reduced renal formation of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids.

 

Gene Ontology (GO) classifications

All GO classifications: (42 annotations)

Process	aromatic compound catabolic process, cholesterol homeostasis, ...
Component	cytoplasm, cytosol, ...
Function	10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity, 4-nitrophenylphosphatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (113)    Tissues (95)    Images (29)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	113

cDNA source data(133)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(133) cDNA(133)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022040 (Evidence)
Entrez Gene	13850 (Evidence)
UniGene	15295
DFCI	TC1575768, TC1746244
DoTS	DT.101224048, DT.534872, DT.55240878, DT.97365736
NIA Mouse Gene Index	U035700
EC	3.1.3.76, 3.3.2.10
PDB	1CQZ, 1CR6, 1EK1, 1EK2
Consensus CDS Project	CCDS27218.1
International Mouse Knockout Project Status	Ephx2

Sequences

Length	Strain/Species
genomic	13850	NCBI Gene Model | MGI Sequence Detail	40124	C57BL/6J
transcript	NM_001271402	RefSeq | MGI Sequence Detail	2142	C57BL/6
polypeptide	P34914	UniProt | EBI | MGI Sequence Detail	554	Not Applicable

All sequences(30) RefSeq(8) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(174 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000073	Alpha/beta hydrolase fold-1
InterPro	IPR000639	Epoxide hydrolase-like
InterPro	IPR023214	HAD-like domain
InterPro	IPR006402	HAD-superfamily hydrolase, subfamily IA, variant 3
InterPro	IPR023198	Phosphoglycolate phosphatase, domain 2
InterPro	IPR011945	Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal
Protein Ontology	PR:000007135	epoxide hydrolase 2

Graphical View of Protein Domain Structure

References

(Earliest) J:7687 Simmons DL, et al., Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes. J Biol Chem. 1985 Jan 10;260(1):515-21
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(73)

Other accession IDs

MGD-MRK-16276, MGI:2145794