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Ephx2 Gene Detail
Summary
  • Symbol
    Ephx2
  • Name
    epoxide hydrolase 2, cytoplasmic
  • Synonyms
    Eph2, sEH, sEP
  • Feature Type
    protein coding gene
  • IDs
    MGI:99500
    NCBI Gene: 13850
  • Gene Overview
    MyGene.info: EPHX2
Location & Maps
more
  • Sequence Map
    Chr14:66084377-66124500 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40124 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 34.36 cM, cytoband D
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    EPHX2, epoxide hydrolase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EPHX2, epoxide hydrolase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CEH, SEH
  • Links
    NCBI Gene ID: 2053
    neXtProt AC: NX_P34913

  • Chr Location
    8p21; chr8:27491002-27544922 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 37558
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: EPHX2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human EPHX2 associations

Human Disease Mouse Models
       Hypercholesterolemia, Familial   OMIM: 143890
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 4 genetic backgrounds
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    5
  • Genomic Mutations
    1 involving Ephx2
  • Incidental Mutations
Males homozygous for a targeted null mutation display a significant reduction in blood pressure both in the absence and presence of dietary salt loading. Both sexes exhibit altered arachidonic acid metabolism and reduced renal formation of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022040 Ensembl Gene Model | MGI Sequence Detail 40124 C57BL/6J ±  kb
transcript ENSMUST00000070515 Ensembl | MGI Sequence Detail 2035 Not Applicable  
polypeptide ENSMUSP00000069209 Ensembl | MGI Sequence Detail 554 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    191 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 133
    cDNA 133

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16276, MGI:2145794
References
more
  • Summaries
    All 84
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 43
  • Earliest
    J:7687 Simmons DL, et al., Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes. J Biol Chem. 1985 Jan 10;260(1):515-21
  • Latest
    J:234704 Froogh G, et al., Female-favorable attenuation of coronary myogenic constriction via reciprocal activations of epoxyeicosatrienoic acids and nitric oxide. Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1448-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory