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F11 Gene Detail
Summary
  • Symbol
    F11
  • Name
    coagulation factor XI
  • Synonyms
    1600027G01Rik, Cf11, FXI, plasma thromboplastin antecedent
  • Feature Type
    protein coding gene
  • IDs
    MGI:99481
    NCBI Gene: 109821
  • Gene Overview
    MyGene.info: F11
Location & Maps
more
  • Sequence Map
    Chr8:45241170-45262031 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20862 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 25.14 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    F11, coagulation factor XI
  • Vertebrate Orthologs
    9
  • Human Ortholog
    F11, coagulation factor XI
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FXI
  • Links
    NCBI Gene ID: 2160
    neXtProt AC: NX_P03951

  • Chr Location
    4q35; chr4:186265945-186289681 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with F11 mouse models; 1 with human F11 associations

Human Disease Mouse Models
       Factor XI Deficiency   OMIM: 612416 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    36 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving F11
  • Incidental Mutations
Mice homozygous for a knock-out allele show a tendency for slightly prolonged tail transection bleeding times and are protected from vessel-occluding fibrin formation after transient ischemic brain injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031645 Ensembl Gene Model | MGI Sequence Detail 20862 C57BL/6J ±  kb
transcript ENSMUST00000034064 Ensembl | MGI Sequence Detail 2244 Not Applicable  
polypeptide ENSMUSP00000034064 Ensembl | MGI Sequence Detail 624 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    113 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 1
    cDNA 15
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-16255, MGI:1919281, MGI:2142579
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:24378 Mills KA, et al., Genetic mapping near the myd locus on mouse chromosome 8. Mamm Genome. 1995 Apr;6(4):278-80
  • Latest
    J:226441 Nickel KF, et al., The polyphosphate-factor XII pathway drives coagulation in prostate cancer-associated thrombosis. Blood. 2015 Sep 10;126(11):1379-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory