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F11
Gene Detail
Symbol

Name
ID
F11
coagulation factor XI
MGI:99481
Synonyms
1600027G01Rik, Cf11, FXI, plasma thromboplastin antecedent
Feature Type
protein coding gene
Genetic Map
Chromosome 8
25.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:45241170-45262031 bp, - strand
From NCBI annotation of GRCm38

  20862 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:86654  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: plasma kallikrein/coagulation factor XI
Gene Tree: F11

Human
homologs
Human Homolog F11, coagulation factor XI
NCBI Gene ID 2160
neXtProt AC  NX_P03951
Human Synonyms  FXI
Human Chr (Location)  4q35; chr4:186265945-186289681 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human F11
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show a tendency for slightly prolonged tail transection bleeding times and are protected from vessel-occluding fibrin formation after transient ischemic brain injury.
 
Interactions
F11 interacts with 75 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process blood coagulation, hemostasis, ...
Component extracellular region, extracellular space, ...
Function catalytic activity, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (21)    Tissues (2)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 21
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(15) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031645 (Evidence)
Entrez Gene109821 (Evidence)
UniGene33326
DFCITC1586049
DoTSDT.40182577
NIA Mouse Gene IndexU029774
EC3.4.21.27
Consensus CDS ProjectCCDS22274.1
International Mouse Knockout Project StatusF11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 109821 NCBI Gene Model | MGI Sequence Detail 20862 C57BL/6J ±  kb
transcript NM_028066 RefSeq | MGI Sequence Detail 2246 C57BL/6 
polypeptide Q91Y47 UniProt | EBI | MGI Sequence Detail 624 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(8) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(113 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000177 Apple domain
InterPro IPR003609 Apple-like
InterPro IPR003014 PAN-1 domain
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000007295 coagulation factor XI
Graphical View of Protein Domain Structure
References
(Earliest) J:24378 Mills KA, et al., Genetic mapping near the myd locus on mouse chromosome 8. Mamm Genome. 1995 Apr;6(4):278-80
(Latest) J:203644 Funnell AP, et al., A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden. Am J Hum Genet. 2013 Mar 7;92(3):460-7
All references(43)
Other
accession IDs
MGD-MRK-16255, MGI:1919281, MGI:2142579

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory