F11
Gene Detail

Symbol Name ID

F11 coagulation factor XI MGI:99481

Synonyms

1600027G01Rik, Cf11, FXI, plasma thromboplastin antecedent

Feature Type

protein coding gene

Genetic Map

Chromosome 8

25.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:45241170-45262031 bp, - strand From NCBI annotation of GRCm38   20862 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:86654  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: plasma kallikrein/coagulation factor XI
Gene Tree: F11

Human homologs

Human Homolog		F11, coagulation factor XI
NCBI Gene ID		2160
neXtProt AC		NX_P03951
Human Synonyms		FXI
Human Chr (Location)		4q35; chr4:187187118-187210835 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human F11

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for a knock-out allele show a tendency for slightly prolonged tail transection bleeding times and are protected from vessel-occluding fibrin formation after transient ischemic brain injury.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	blood coagulation, hemostasis, ...
Component	extracellular region, extracellular region part, ...
Function	catalytic activity, heparin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (21)    Tissues (2)    Images (21)
Theiler Stages: 23

Assay Type	Results
RNA in situ	21

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(1) cDNA(15) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000031645 (Evidence)
Entrez Gene	109821 (Evidence)
UniGene	33326
DFCI	TC1586049
DoTS	DT.40182577
NIA Mouse Gene Index	U029774
EC	3.4.21.27
Consensus CDS Project	CCDS22274.1
International Mouse Knockout Project Status	F11

Sequences

Length	Strain/Species
genomic	109821	NCBI Gene Model | MGI Sequence Detail	20862	C57BL/6J
transcript	NM_028066	RefSeq | MGI Sequence Detail	2246	C57BL/6
polypeptide	Q91Y47	UniProt | EBI | MGI Sequence Detail	624	Not Applicable

All sequences(14) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(112 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000177	Apple domain
InterPro	IPR003609	Apple-like
InterPro	IPR003014	PAN-1 domain
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000007295	coagulation factor XI

Graphical View of Protein Domain Structure

References

(Earliest) J:24378 Mills KA, et al., Genetic mapping near the myd locus on mouse chromosome 8. Mamm Genome. 1995 Apr;6(4):278-80
(Latest) J:178964 Luo D, et al., Factor XI-Deficient Mice Display Reduced Inflammation, Coagulopathy, and Bacterial Growth during Listeriosis. Infect Immun. 2012 Jan;80(1):91-9
All references(39)

Other accession IDs

MGD-MRK-16255, MGI:1919281, MGI:2142579