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Cckbr
Gene Detail
Symbol

Name
ID
Cckbr
cholecystokinin B receptor
MGI:99479
Synonyms
CCK2/gastrin, CCK2R, CCK-B/gastrin receptor, CCKR-2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
55.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr7:105425817-105470898 bp, + strand
From VEGA annotation of GRCm38

  45082 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7258  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 2 zebrafish

Protein SuperFamily: cholecystokinin receptor
Gene Tree: Cckbr

Human
homologs
Human Homolog CCKBR, cholecystokinin B receptor
NCBI Gene ID 887
neXtProt AC  NX_P32239
Human Synonyms  CCK2R, CCK-B, GASR
Human Chr (Location)  11p15.4; chr11:6259611-6272127 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice show gastic mucoca defects, high gastic pH and hypergastrenemia. Homozygotes for a null allele also exhibit higher energy intake and expenditure, less susceptibility to endotoxin shock, altered pain and mechanical sensitivity, and behavioral changes to isolation and addictive drugs.
 
Interactions
Cckbr interacts with 148 markers (Mir1b, Mir18b, Mir30a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process apoptotic process, behavioral defense response, ...
Component cytoplasm, cytosol, ...
Function gastrin receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (100)    Tissues (69)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 65
Northern blot 6
RT-PCR 29
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(2) cDNA(13) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000042484 (Evidence)
Ensembl Gene ModelENSMUSG00000030898 (Evidence)
Entrez Gene12426 (Evidence)
UniGene44513
DFCITC1579814
DoTSDT.50315351, DT.87029330
NIA Mouse Gene IndexU008562
Consensus CDS ProjectCCDS21651.1
International Mouse Knockout Project StatusCckbr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042484 VEGA Gene Model | MGI Sequence Detail 45082 C57BL/6J ±  kb
transcript OTTMUST00000112015 VEGA | MGI Sequence Detail 2484 Not Applicable 
polypeptide OTTMUSP00000062861 VEGA | MGI Sequence Detail 453 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(5)
Polymorphisms
RFLP(4) : SNPs within 2kb(450 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009126 Cholecystokinin receptor
InterPro IPR000314 Gastrin receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001217 cholecystokinin receptor 2
References
(Earliest) J:23249 Huppi K, et al., Chromosomal localization of the gastric and brain receptors for cholecystokinin (CCKAR and CCKBR) in human and mouse. Genomics. 1995 Feb 10;25(3):727-9
(Latest) J:197082 Li H, et al., Behavioral and cortical EEG evaluations confirm the roles of both CCKA and CCKB receptors in mouse CCK-induced anxiety. Behav Brain Res. 2013 Jan 15;237:325-32
All references(87)
Other
accession IDs
MGD-MRK-16253

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory